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The map label for this gene is accC [H]

Identifier: 46446406

GI number: 46446406

Start: 952814

End: 954175

Strand: Direct

Name: accC [H]

Synonym: pc0772

Alternate gene names: 46446406

Gene position: 952814-954175 (Clockwise)

Preceding gene: 46446405

Following gene: 46446407

Centisome position: 39.46

GC content: 37.89

Gene sequence:

>1362_bases
ATGCAAAAAGTTCTTATCGCTAACAGAGGCGAGATTGCCGTTCGAATTATTCGTGCTTGTCACGATTTAGGTCTTCAAAC
TGTGGCTGTTTATTCGCAAGCAGATGCTGAAGCCTTACACGTTCTTCATGCTGACGAAGCCATTTGTATTGGAGAAGCCC
CTTCCCATAAATCTTATCTTAAAGTGCCAAATATCCTTTCTGCTTGTGAAATTACCGGAGCTGATGCGATCCATCCGGGT
TACGGTTTTTTAAGCGAAAATGCAAATTTTGCCTCTATTTGTGAAAGCTGTGGCTTAAACTTTATTGGACCGGCTCCCCA
ATCTATTGCATTGCTTGGTGATAAAGCTAAAGCTAAAGCAACAGCAAAAAAAGCTGGTTGTCCTGTTATCCCAGGCTCAG
ATGGAGTCGTAGTGGATATTAAAGAAGCTTTGAAAGACGCAAAAAAATTAGGTTTCCCTATTTTCATTAAAGCTGTTGCG
GGAGGTGGCGGGAAAGGAATTCGGATAGCTTACAACGAAGAAGAGTTTACTAAGCTATTTGCAGCTGCACGAGCTGAAGC
AGAGGTAAGTTTTGGGAATCCAGACGTCTATTTAGAAAAAATGATTATGAATCCTCGACATATTGAAGTGCAAGTGTTAG
GGGATAAATTTGGTCATTATATTCATTTAGGAGAAAGAGATTGCACTACTCAACGACGCAGACAAAAACTCATTGAAGAG
TCTCCAAGTCCGGTTCTCAGTCAAAAAATGCGCCAAAAGATTGGTCAAGCAGCTGTCAATGTTGTTAAAGAAGCAAATTA
TTTTTCTGCGGGAACAGTAGAATTCCTTTTAGACAAAGATCAAAACTTTTATTTTATGGAAGTAAATACACGTATTCAAG
TTGAGCATACGGTCACAGAAGAATTAACAGGTATTGATCTTGTAATGGAACAGCTCAAAATTGCTCGTGGAGAAAAATTG
ATTTTAGAACAAAAGGATGTAAAATTCACTGGTCATGTAATTCAATTTAGAATTAATGCAGAAAATCCTAGCCACAATTT
TGCTCCCTCTCCTGGAAAATTAGAATATTATCTTCCTCCTGGTGGCCCCCATGTTAGAGTTGACAGCGCTTGTTATTCAG
GATATTCCATTCCTCCTAACTATGATTCAATGATTGCTAAATTAATTGTGAAGGGTAAAGATCGTACAGAAACTATTGCA
ATAGGAAAAAGAGCTCTAAGTGAATTTCATATCGGAGGAGTTAATTCCACAATACCTTTTCACCTTTATATGCTAGAAGA
TCCAAAATTTTTAAATGCAGATTTTGATCTGACTTATATCGATAACCTAATTGCAGAAGGTAATCGCTTTGAATTAGAAT
AG

Upstream 100 bases:

>100_bases
AGCAAATGTCTCAGGAGCAATAGCTGAAATCTTGGTTGAATCAGGACAGCCTGTAGAATTTGGTACGAAACTTTTCCGAA
TCGTTGAGTAATTTTTATTT

Downstream 100 bases:

>100_bases
ATATTGTCCAGTCTTTTGCTTAAAATTTATAAGAAAAGAATTCTAAAATATATATTCCTTGTAAATTTTGAGCAAAAATA
TTGAATTTATTGGTTCACAA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MQKVLIANRGEIAVRIIRACHDLGLQTVAVYSQADAEALHVLHADEAICIGEAPSHKSYLKVPNILSACEITGADAIHPG
YGFLSENANFASICESCGLNFIGPAPQSIALLGDKAKAKATAKKAGCPVIPGSDGVVVDIKEALKDAKKLGFPIFIKAVA
GGGGKGIRIAYNEEEFTKLFAAARAEAEVSFGNPDVYLEKMIMNPRHIEVQVLGDKFGHYIHLGERDCTTQRRRQKLIEE
SPSPVLSQKMRQKIGQAAVNVVKEANYFSAGTVEFLLDKDQNFYFMEVNTRIQVEHTVTEELTGIDLVMEQLKIARGEKL
ILEQKDVKFTGHVIQFRINAENPSHNFAPSPGKLEYYLPPGGPHVRVDSACYSGYSIPPNYDSMIAKLIVKGKDRTETIA
IGKRALSEFHIGGVNSTIPFHLYMLEDPKFLNADFDLTYIDNLIAEGNRFELE

Sequences:

>Translated_453_residues
MQKVLIANRGEIAVRIIRACHDLGLQTVAVYSQADAEALHVLHADEAICIGEAPSHKSYLKVPNILSACEITGADAIHPG
YGFLSENANFASICESCGLNFIGPAPQSIALLGDKAKAKATAKKAGCPVIPGSDGVVVDIKEALKDAKKLGFPIFIKAVA
GGGGKGIRIAYNEEEFTKLFAAARAEAEVSFGNPDVYLEKMIMNPRHIEVQVLGDKFGHYIHLGERDCTTQRRRQKLIEE
SPSPVLSQKMRQKIGQAAVNVVKEANYFSAGTVEFLLDKDQNFYFMEVNTRIQVEHTVTEELTGIDLVMEQLKIARGEKL
ILEQKDVKFTGHVIQFRINAENPSHNFAPSPGKLEYYLPPGGPHVRVDSACYSGYSIPPNYDSMIAKLIVKGKDRTETIA
IGKRALSEFHIGGVNSTIPFHLYMLEDPKFLNADFDLTYIDNLIAEGNRFELE
>Mature_453_residues
MQKVLIANRGEIAVRIIRACHDLGLQTVAVYSQADAEALHVLHADEAICIGEAPSHKSYLKVPNILSACEITGADAIHPG
YGFLSENANFASICESCGLNFIGPAPQSIALLGDKAKAKATAKKAGCPVIPGSDGVVVDIKEALKDAKKLGFPIFIKAVA
GGGGKGIRIAYNEEEFTKLFAAARAEAEVSFGNPDVYLEKMIMNPRHIEVQVLGDKFGHYIHLGERDCTTQRRRQKLIEE
SPSPVLSQKMRQKIGQAAVNVVKEANYFSAGTVEFLLDKDQNFYFMEVNTRIQVEHTVTEELTGIDLVMEQLKIARGEKL
ILEQKDVKFTGHVIQFRINAENPSHNFAPSPGKLEYYLPPGGPHVRVDSACYSGYSIPPNYDSMIAKLIVKGKDRTETIA
IGKRALSEFHIGGVNSTIPFHLYMLEDPKFLNADFDLTYIDNLIAEGNRFELE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=45.8049886621315, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=46.7561521252796, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=46.7561521252796, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=46.7561521252796, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=43.6241610738255, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=43.6241610738255, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=43.6241610738255, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=31.1890838206628, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=31.1890838206628, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=31.1890838206628, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=31.1890838206628, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=31.1890838206628, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=30.7392996108949, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI18105007, Length=238, Percent_Identity=24.3697478991597, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=50, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=45.1901565995526, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=444, Percent_Identity=44.3693693693694, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71987519, Length=451, Percent_Identity=44.7893569844789, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133931226, Length=499, Percent_Identity=29.4589178356713, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=29.0766208251473, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=453, Percent_Identity=31.1258278145695, Blast_Score=195, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=42.7293064876958, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=450, Percent_Identity=42.4444444444444, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=43.1767337807606, Blast_Score=342, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=32.5431034482759, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=31.5992292870906, Blast_Score=208, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=45.823927765237, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=45.9641255605381, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=45.1851851851852, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI161076409, Length=508, Percent_Identity=31.2992125984252, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161076407, Length=508, Percent_Identity=31.2992125984252, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586460, Length=508, Percent_Identity=31.2992125984252, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24586458, Length=508, Percent_Identity=31.2992125984252, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49790; Mature: 49790

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVLIANRGEIAVRIIRACHDLGLQTVAVYSQADAEALHVLHADEAICIGEAPSHKSYL
CCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCCC
KVPNILSACEITGADAIHPGYGFLSENANFASICESCGLNFIGPAPQSIALLGDKAKAKA
CCCCHHHHHHCCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCEEEEECCCHHHHH
TAKKAGCPVIPGSDGVVVDIKEALKDAKKLGFPIFIKAVAGGGGKGIRIAYNEEEFTKLF
HHHHCCCCCCCCCCCEEEEHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECHHHHHHHH
AAARAEAEVSFGNPDVYLEKMIMNPRHIEVQVLGDKFGHYIHLGERDCTTQRRRQKLIEE
HHHHCCCEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHC
SPSPVLSQKMRQKIGQAAVNVVKEANYFSAGTVEFLLDKDQNFYFMEVNTRIQVEHTVTE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEEEEHHH
ELTGIDLVMEQLKIARGEKLILEQKDVKFTGHVIQFRINAENPSHNFAPSPGKLEYYLPP
HHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECC
GGPHVRVDSACYSGYSIPPNYDSMIAKLIVKGKDRTETIAIGKRALSEFHIGGVNSTIPF
CCCEEEECHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCE
HLYMLEDPKFLNADFDLTYIDNLIAEGNRFELE
EEEEECCCCEECCCCCHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MQKVLIANRGEIAVRIIRACHDLGLQTVAVYSQADAEALHVLHADEAICIGEAPSHKSYL
CCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCCC
KVPNILSACEITGADAIHPGYGFLSENANFASICESCGLNFIGPAPQSIALLGDKAKAKA
CCCCHHHHHHCCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCEEEEECCCHHHHH
TAKKAGCPVIPGSDGVVVDIKEALKDAKKLGFPIFIKAVAGGGGKGIRIAYNEEEFTKLF
HHHHCCCCCCCCCCCEEEEHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECHHHHHHHH
AAARAEAEVSFGNPDVYLEKMIMNPRHIEVQVLGDKFGHYIHLGERDCTTQRRRQKLIEE
HHHHCCCEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHC
SPSPVLSQKMRQKIGQAAVNVVKEANYFSAGTVEFLLDKDQNFYFMEVNTRIQVEHTVTE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEEEEHHH
ELTGIDLVMEQLKIARGEKLILEQKDVKFTGHVIQFRINAENPSHNFAPSPGKLEYYLPP
HHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECC
GGPHVRVDSACYSGYSIPPNYDSMIAKLIVKGKDRTETIAIGKRALSEFHIGGVNSTIPF
CCCEEEECHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCE
HLYMLEDPKFLNADFDLTYIDNLIAEGNRFELE
EEEEECCCCEECCCCCHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]