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The map label for this gene is accB [H]

Identifier: 46446405

GI number: 46446405

Start: 952292

End: 952804

Strand: Direct

Name: accB [H]

Synonym: pc0771

Alternate gene names: 46446405

Gene position: 952292-952804 (Clockwise)

Preceding gene: 46446404

Following gene: 46446406

Centisome position: 39.44

GC content: 40.35

Gene sequence:

>513_bases
GTGGAATTAAAACACATCAAAGAACTTATGGCAGTGATGGGGCGAACAGGAACAAAACGGCTCCAACTTAAACAAAATGA
ATTTGAATTGATACTCGAACGACAAGAGAATGGGCATGGACGATCAATAGCTGATTCCACACTAATCGATTCAGAAGAAC
AAATTAGAACATATTTACAACAACGTACGGATCAGGCCCTTTCCCATGGTGCCGAAATGCCAACTGCCCGCCCTCCAATT
CCTATTGCTGTTGAAGCTCCCAAAGTCGATACTAATAGCCTTTATGTCACATCTCCTATGGTAGGAACTTTTTATGGAGC
CCCTTCACCTGATGATCCAAGTTTTATCAAAGTGGGAGATCGAATCGAAAAAAATAGTGTGGTTTGTATTATCGAAGCGA
TGAAAGTAATGAATGAAATTAAAGCAAATGTCTCAGGAGCAATAGCTGAAATCTTGGTTGAATCAGGACAGCCTGTAGAA
TTTGGTACGAAACTTTTCCGAATCGTTGAGTAA

Upstream 100 bases:

>100_bases
TCGAGATTCCGACCCTTAAAGGAAAAATTTACTCAAGTCAACAAGGGACAAGCCCTTTTTAAGATGTTCTCATTTTTATT
TAATTAGAAAGGAAATCGAC

Downstream 100 bases:

>100_bases
TTTTTATTTATGCAAAAAGTTCTTATCGCTAACAGAGGCGAGATTGCCGTTCGAATTATTCGTGCTTGTCACGATTTAGG
TCTTCAAACTGTGGCTGTTT

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MELKHIKELMAVMGRTGTKRLQLKQNEFELILERQENGHGRSIADSTLIDSEEQIRTYLQQRTDQALSHGAEMPTARPPI
PIAVEAPKVDTNSLYVTSPMVGTFYGAPSPDDPSFIKVGDRIEKNSVVCIIEAMKVMNEIKANVSGAIAEILVESGQPVE
FGTKLFRIVE

Sequences:

>Translated_170_residues
MELKHIKELMAVMGRTGTKRLQLKQNEFELILERQENGHGRSIADSTLIDSEEQIRTYLQQRTDQALSHGAEMPTARPPI
PIAVEAPKVDTNSLYVTSPMVGTFYGAPSPDDPSFIKVGDRIEKNSVVCIIEAMKVMNEIKANVSGAIAEILVESGQPVE
FGTKLFRIVE
>Mature_170_residues
MELKHIKELMAVMGRTGTKRLQLKQNEFELILERQENGHGRSIADSTLIDSEEQIRTYLQQRTDQALSHGAEMPTARPPI
PIAVEAPKVDTNSLYVTSPMVGTFYGAPSPDDPSFIKVGDRIEKNSVVCIIEAMKVMNEIKANVSGAIAEILVESGQPVE
FGTKLFRIVE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=169, Percent_Identity=34.3195266272189, Blast_Score=97, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 18839; Mature: 18839

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKHIKELMAVMGRTGTKRLQLKQNEFELILERQENGHGRSIADSTLIDSEEQIRTYLQ
CCHHHHHHHHHHHCCCCCCEEEEECCHHHHHEECCCCCCCCCCCCHHHCCCHHHHHHHHH
QRTDQALSHGAEMPTARPPIPIAVEAPKVDTNSLYVTSPMVGTFYGAPSPDDPSFIKVGD
HHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCEEECCCCCCCCCCEEEECC
RIEKNSVVCIIEAMKVMNEIKANVSGAIAEILVESGQPVEFGTKLFRIVE
CCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MELKHIKELMAVMGRTGTKRLQLKQNEFELILERQENGHGRSIADSTLIDSEEQIRTYLQ
CCHHHHHHHHHHHCCCCCCEEEEECCHHHHHEECCCCCCCCCCCCHHHCCCHHHHHHHHH
QRTDQALSHGAEMPTARPPIPIAVEAPKVDTNSLYVTSPMVGTFYGAPSPDDPSFIKVGD
HHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCEEECCCCCCCCCCEEEECC
RIEKNSVVCIIEAMKVMNEIKANVSGAIAEILVESGQPVEFGTKLFRIVE
CCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]