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The map label for this gene is udhA [H]

Identifier: 46446359

GI number: 46446359

Start: 879588

End: 880985

Strand: Direct

Name: udhA [H]

Synonym: pc0725

Alternate gene names: 46446359

Gene position: 879588-880985 (Clockwise)

Preceding gene: 46446358

Following gene: 46446360

Centisome position: 36.43

GC content: 38.2

Gene sequence:

>1398_bases
ATGGAAGAAATTAAAACAGATATCGTTATTATTGGATCAGGGCCTGCAGGACAAAAAGCTGCGATTCAAGCCGCTAAGTT
AGGAAAAAATGTCATTGTAATTGAAAAAGAGCCTGAATTAGGTGGTGCTTGTTTATACTCGGGAACTATTCCCTCTAAAA
CTTTTAGAGAAGCTGTTGTTGATTTAACCCGCTTCCATGATCGTCATTTTGCAGGAAAAGACTATATTCTTCCGAATGTC
ACGATTGATGAACTCAATGTTCGCCTTCATACCGTCATTAATGAAGAACGGAACATTATCACGAGGCAATTTAAAAAAAA
TAGCATTCGTGTTATTCAAGGATCAGCAAGATTTGAAAATCAACACACTTTAATTGTTGTCGATAATGATTTTCGGCTTA
AATATCAAATCAAAGCAACAAGTTTTATTATCGCAACAGGCTCTAATCCTCGCAATCCTCCTGATGTTCCATTTGATCAA
CAAGTAATTTTAGATTCTACTACCTTGCTTGGCATCGGCCGAGTTCCTAAAAGCATGATTGTCTTGGGAGGAGGGATTAT
TGGATCAGAGTATGCAAGCTTTTTTGCAGCTCTTGGAACAGAAGTCACAGTGATCGATCGAAAAGATCATATGCTTCCTT
TGTTAGACGCAGAAATCGGCATTCATTTACAAACAGCTTTGACAGATATCGGATTAAAATTCTTAGGAAAAAAAGAACCT
GTAGAAATTTCAAGAGTAGAAGACCACGCTTATGTCAAATTCAAAGATGGTTCTTCTCTAGAAGCAGATGTTTTACTTTA
TGCATTGGGGCGACTTGCCAACATCGAAGCTTTACACGTCGAAAATACAGGAATCATCGTTGATGCGAAAGGCTATATTC
CTGTGAATGCCTTATTCCAAACGGTAATTCCCCATATTTATGCGGTGGGAGACGTCATTGGAGGCCCATGTTTAGCCTCG
ACAAGTATGGAACAAGGACGTTTGGCTGCTCGCCATGCTTGTGGCGTTCAAACGCATCATTTTCCGACTTTTTATCCTGT
GGGAATTTATACTATTCCTGAAATTTCAAGCTGCGGTTATACAGAAGAAGAATTAAAAGCGTGGGGATTTCATTATGAAG
TGGGAAGAGCTCATTATTATGAAATTGCCCGTAGCCATATCGCTGGTAGCAATACAGGACTTTTTAAAATTCTTTTTCAT
GCCGAAACCTTAGAAATTTTAGGGGTTCATGTCATTGGTCGAAATGCCACAGAGGTGATTCACATTGGTCAGATGGGAAT
CAGTTTTCGAGCCCATATCGATTATTTTATTGATCACGTTTTTAACTATCCGACTTATGCTGAAGGGTATAGAGTAGCTG
CATTAAACGGAGTAAATAAAATTAAATTTAAAAAATAA

Upstream 100 bases:

>100_bases
GGTTTTTCAGCATCGATAGTTATATTAATTATTTGATGGATTTTTTCATTTGAACGCGTTATATCAAAGTTTTTTAGAGA
TTAATTGCTTATAAGGGATT

Downstream 100 bases:

>100_bases
TTGAATTTAACTCTTTGATAAACGCATTTGGTTTTTTTATATTTGTTTTTTCTCCTTGAAATTCCACCTATTTACTGGCA
TCTTAAAACCTCAACGAAAA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MEEIKTDIVIIGSGPAGQKAAIQAAKLGKNVIVIEKEPELGGACLYSGTIPSKTFREAVVDLTRFHDRHFAGKDYILPNV
TIDELNVRLHTVINEERNIITRQFKKNSIRVIQGSARFENQHTLIVVDNDFRLKYQIKATSFIIATGSNPRNPPDVPFDQ
QVILDSTTLLGIGRVPKSMIVLGGGIIGSEYASFFAALGTEVTVIDRKDHMLPLLDAEIGIHLQTALTDIGLKFLGKKEP
VEISRVEDHAYVKFKDGSSLEADVLLYALGRLANIEALHVENTGIIVDAKGYIPVNALFQTVIPHIYAVGDVIGGPCLAS
TSMEQGRLAARHACGVQTHHFPTFYPVGIYTIPEISSCGYTEEELKAWGFHYEVGRAHYYEIARSHIAGSNTGLFKILFH
AETLEILGVHVIGRNATEVIHIGQMGISFRAHIDYFIDHVFNYPTYAEGYRVAALNGVNKIKFKK

Sequences:

>Translated_465_residues
MEEIKTDIVIIGSGPAGQKAAIQAAKLGKNVIVIEKEPELGGACLYSGTIPSKTFREAVVDLTRFHDRHFAGKDYILPNV
TIDELNVRLHTVINEERNIITRQFKKNSIRVIQGSARFENQHTLIVVDNDFRLKYQIKATSFIIATGSNPRNPPDVPFDQ
QVILDSTTLLGIGRVPKSMIVLGGGIIGSEYASFFAALGTEVTVIDRKDHMLPLLDAEIGIHLQTALTDIGLKFLGKKEP
VEISRVEDHAYVKFKDGSSLEADVLLYALGRLANIEALHVENTGIIVDAKGYIPVNALFQTVIPHIYAVGDVIGGPCLAS
TSMEQGRLAARHACGVQTHHFPTFYPVGIYTIPEISSCGYTEEELKAWGFHYEVGRAHYYEIARSHIAGSNTGLFKILFH
AETLEILGVHVIGRNATEVIHIGQMGISFRAHIDYFIDHVFNYPTYAEGYRVAALNGVNKIKFKK
>Mature_465_residues
MEEIKTDIVIIGSGPAGQKAAIQAAKLGKNVIVIEKEPELGGACLYSGTIPSKTFREAVVDLTRFHDRHFAGKDYILPNV
TIDELNVRLHTVINEERNIITRQFKKNSIRVIQGSARFENQHTLIVVDNDFRLKYQIKATSFIIATGSNPRNPPDVPFDQ
QVILDSTTLLGIGRVPKSMIVLGGGIIGSEYASFFAALGTEVTVIDRKDHMLPLLDAEIGIHLQTALTDIGLKFLGKKEP
VEISRVEDHAYVKFKDGSSLEADVLLYALGRLANIEALHVENTGIIVDAKGYIPVNALFQTVIPHIYAVGDVIGGPCLAS
TSMEQGRLAARHACGVQTHHFPTFYPVGIYTIPEISSCGYTEEELKAWGFHYEVGRAHYYEIARSHIAGSNTGLFKILFH
AETLEILGVHVIGRNATEVIHIGQMGISFRAHIDYFIDHVFNYPTYAEGYRVAALNGVNKIKFKK

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=471, Percent_Identity=32.6963906581741, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI291045266, Length=439, Percent_Identity=26.1958997722096, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=25.8771929824561, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=24.468085106383, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI33519430, Length=435, Percent_Identity=24.8275862068966, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519428, Length=435, Percent_Identity=24.8275862068966, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519426, Length=435, Percent_Identity=24.8275862068966, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI148277065, Length=435, Percent_Identity=24.8275862068966, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=24.8275862068966, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI291045268, Length=356, Percent_Identity=26.123595505618, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=41.7391304347826, Blast_Score=351, Evalue=5e-98,
Organism=Escherichia coli, GI1786307, Length=461, Percent_Identity=30.58568329718, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=29.5805739514349, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789915, Length=446, Percent_Identity=27.1300448430493, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=33.5497835497836, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17557007, Length=457, Percent_Identity=27.3522975929978, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=22.6337448559671, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71983429, Length=347, Percent_Identity=24.207492795389, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71983419, Length=347, Percent_Identity=24.207492795389, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559934, Length=250, Percent_Identity=26.4, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=31.6455696202532, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=27.0440251572327, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=24.9457700650759, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=33.9092872570194, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=29.0187891440501, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=29.0187891440501, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=29.0187891440501, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=28.4518828451883, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51333; Mature: 51333

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEIKTDIVIIGSGPAGQKAAIQAAKLGKNVIVIEKEPELGGACLYSGTIPSKTFREAVV
CCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHH
DLTRFHDRHFAGKDYILPNVTIDELNVRLHTVINEERNIITRQFKKNSIRVIQGSARFEN
HHHHHHCCCCCCCCEECCCCEEHHCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCC
QHTLIVVDNDFRLKYQIKATSFIIATGSNPRNPPDVPFDQQVILDSTTLLGIGRVPKSMI
CCEEEEEECCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECEEEEEECCCCCEEE
VLGGGIIGSEYASFFAALGTEVTVIDRKDHMLPLLDAEIGIHLQTALTDIGLKFLGKKEP
EEECCCCHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHCCCCCC
VEISRVEDHAYVKFKDGSSLEADVLLYALGRLANIEALHVENTGIIVDAKGYIPVNALFQ
EEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCCHHHHHH
TVIPHIYAVGDVIGGPCLASTSMEQGRLAARHACGVQTHHFPTFYPVGIYTIPEISSCGY
HHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCC
TEEELKAWGFHYEVGRAHYYEIARSHIAGSNTGLFKILFHAETLEILGVHVIGRNATEVI
CHHHHHHCCEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEEEEECCCCEEEE
HIGQMGISFRAHIDYFIDHVFNYPTYAEGYRVAALNGVNKIKFKK
EECCCCCEEEHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECC
>Mature Secondary Structure
MEEIKTDIVIIGSGPAGQKAAIQAAKLGKNVIVIEKEPELGGACLYSGTIPSKTFREAVV
CCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHH
DLTRFHDRHFAGKDYILPNVTIDELNVRLHTVINEERNIITRQFKKNSIRVIQGSARFEN
HHHHHHCCCCCCCCEECCCCEEHHCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCC
QHTLIVVDNDFRLKYQIKATSFIIATGSNPRNPPDVPFDQQVILDSTTLLGIGRVPKSMI
CCEEEEEECCEEEEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECEEEEEECCCCCEEE
VLGGGIIGSEYASFFAALGTEVTVIDRKDHMLPLLDAEIGIHLQTALTDIGLKFLGKKEP
EEECCCCHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCEEEEHHHHHHHHHHCCCCCC
VEISRVEDHAYVKFKDGSSLEADVLLYALGRLANIEALHVENTGIIVDAKGYIPVNALFQ
EEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCCHHHHHH
TVIPHIYAVGDVIGGPCLASTSMEQGRLAARHACGVQTHHFPTFYPVGIYTIPEISSCGY
HHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCC
TEEELKAWGFHYEVGRAHYYEIARSHIAGSNTGLFKILFHAETLEILGVHVIGRNATEVI
CHHHHHHCCEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEEEEECCCCEEEE
HIGQMGISFRAHIDYFIDHVFNYPTYAEGYRVAALNGVNKIKFKK
EECCCCCEEEHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]