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The map label for this gene is gpo

Identifier: 45659259

GI number: 45659259

Start: 4218825

End: 4219322

Strand: Reverse

Name: gpo

Synonym: LIC13442

Alternate gene names: 45659259

Gene position: 4219322-4218825 (Counterclockwise)

Preceding gene: 45659264

Following gene: 45659258

Centisome position: 98.65

GC content: 32.13

Gene sequence:

>498_bases
TTGAGGTTCGATATGAACGATACATTATATGATTTAACAGCAACTTTAAATAACGGAAAAGAGCAAAAATTAGAGAATTA
TAAAGGAAAAGTACTCTTAATCGTAAATACCGCTAGCGAATGCGCTTTTACACCACAATATGCAGGTTTACAAAATTTAT
ATAGTAAGTATAAAACTGAGGGGTTGGAAATTTTAGGTTTTCCGTGTGATCAGTTCAAACATCAGGAGCCTGGTTCTGAT
GAAACGATCAAAAACTTTTGTCAAAAGAATTACGGAGTAGAATTTCCTATTTTTAAAAAAATAGAAGTAAATGGAGATAA
CGCTCATCCAGTATTTCGGTTTTTGAGAAACAAGGCTTCTGGTTTTTTTGGAAATTCGATCAAATGGAACTTTACTAAAT
TTTTAGTGGATAAACAAGGAAACGTAATAAAACGTTACTCCCCCATTACAACTCCAGAAAACATCGAGAAAGAAATCCAA
AATCTTTTAAAACGGTAA

Upstream 100 bases:

>100_bases
CATAATTTTAGAAATAAAACTGAAATTTAAAAGCAGTAAAAATTTTTATTGACTAAAATTTGAAATCTATATTTTATAAA
ATTAAATTGTGCACAATTAA

Downstream 100 bases:

>100_bases
AAATAAAACCAACTTCTTTAAAAATGGGAAAGACCGCAAAAGATCTTTTTTTAGAAAATCAGGTTTGTTTTCCACTCTAT
GCCTGTTCAAGAGCTCTGAC

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MRFDMNDTLYDLTATLNNGKEQKLENYKGKVLLIVNTASECAFTPQYAGLQNLYSKYKTEGLEILGFPCDQFKHQEPGSD
ETIKNFCQKNYGVEFPIFKKIEVNGDNAHPVFRFLRNKASGFFGNSIKWNFTKFLVDKQGNVIKRYSPITTPENIEKEIQ
NLLKR

Sequences:

>Translated_165_residues
MRFDMNDTLYDLTATLNNGKEQKLENYKGKVLLIVNTASECAFTPQYAGLQNLYSKYKTEGLEILGFPCDQFKHQEPGSD
ETIKNFCQKNYGVEFPIFKKIEVNGDNAHPVFRFLRNKASGFFGNSIKWNFTKFLVDKQGNVIKRYSPITTPENIEKEIQ
NLLKR
>Mature_165_residues
MRFDMNDTLYDLTATLNNGKEQKLENYKGKVLLIVNTASECAFTPQYAGLQNLYSKYKTEGLEILGFPCDQFKHQEPGSD
ETIKNFCQKNYGVEFPIFKKIEVNGDNAHPVFRFLRNKASGFFGNSIKWNFTKFLVDKQGNVIKRYSPITTPENIEKEIQ
NLLKR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=45.1612903225806, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=45.1612903225806, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI15618997, Length=158, Percent_Identity=39.873417721519, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI192455698, Length=160, Percent_Identity=37.5, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=43.8461538461538, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=35.8695652173913, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI4557629, Length=183, Percent_Identity=34.4262295081967, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI32967607, Length=182, Percent_Identity=32.967032967033, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI6006001, Length=182, Percent_Identity=34.0659340659341, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI33186887, Length=185, Percent_Identity=31.8918918918919, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1788003, Length=170, Percent_Identity=43.5294117647059, Blast_Score=148, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=157, Percent_Identity=46.4968152866242, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=44.3037974683544, Blast_Score=148, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71993584, Length=161, Percent_Identity=39.1304347826087, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193210707, Length=169, Percent_Identity=39.0532544378698, Blast_Score=125, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193209493, Length=167, Percent_Identity=31.7365269461078, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550320, Length=168, Percent_Identity=32.7380952380952, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71999642, Length=80, Percent_Identity=38.75, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71993573, Length=99, Percent_Identity=32.3232323232323, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507603, Length=101, Percent_Identity=35.6435643564356, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=162, Percent_Identity=53.7037037037037, Blast_Score=185, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322228, Length=158, Percent_Identity=55.6962025316456, Blast_Score=184, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6322826, Length=156, Percent_Identity=48.7179487179487, Blast_Score=148, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24656772, Length=158, Percent_Identity=44.9367088607595, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24656767, Length=158, Percent_Identity=44.9367088607595, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24656777, Length=158, Percent_Identity=44.9367088607595, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI85726443, Length=168, Percent_Identity=38.6904761904762, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: 1.11.1.9

Molecular weight: Translated: 19077; Mature: 19077

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDMNDTLYDLTATLNNGKEQKLENYKGKVLLIVNTASECAFTPQYAGLQNLYSKYKTE
CCCCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCC
GLEILGFPCDQFKHQEPGSDETIKNFCQKNYGVEFPIFKKIEVNGDNAHPVFRFLRNKAS
CCEEECCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
GFFGNSIKWNFTKFLVDKQGNVIKRYSPITTPENIEKEIQNLLKR
CCCCCCCEECHHEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRFDMNDTLYDLTATLNNGKEQKLENYKGKVLLIVNTASECAFTPQYAGLQNLYSKYKTE
CCCCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCC
GLEILGFPCDQFKHQEPGSDETIKNFCQKNYGVEFPIFKKIEVNGDNAHPVFRFLRNKAS
CCEEECCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCC
GFFGNSIKWNFTKFLVDKQGNVIKRYSPITTPENIEKEIQNLLKR
CCCCCCCEECHHEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]