| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
Click here to switch to the map view.
The map label for this gene is nprT
Identifier: 45659141
GI number: 45659141
Start: 4076605
End: 4078989
Strand: Reverse
Name: nprT
Synonym: LIC13322
Alternate gene names: 45659141
Gene position: 4078989-4076605 (Counterclockwise)
Preceding gene: 45659142
Following gene: 45659140
Centisome position: 95.37
GC content: 36.6
Gene sequence:
>2385_bases ATGAGACTTTTAAAGTTATTAAAGATCAATTCGAATATAAAGATACTCTTAAGTATGTTTATGATTTCGATATTATTTTC TTGTAAGGATAAGCAGGACCCAGGAATGGAATCTTGGTTGTGGGTTTTAAATCCTGTCCAATTGGATAATAAGGCGCTTT CTGAAAGGACGTATACGTCAGATGGTAGGATAACATTTGCGAAGTTCAATTCGGATCTAGTTCCTTATTCACGTAAACAA GCACCTGAAGTTCTTAAGACGTATTTACAATTACCCTTAACTTCTCAAGCTACATTCTTGCGTTCGGCTCGTGTAGGAGA TTTTGATCACGATCGTTTTCAACAGAGATATAAAGGTGTTAGAGTAGAGAATGGAATTTATACAGTGGTCTCAAAAGAGA ATACGATAGAACTGATGATGGGTGAATTTTACCAAGTTCCAGAGAATTTTAATTCCTCTCCTAAACTATCCGAGTCAGAA GCACTTTCAAAGACTTTAAAACATATCGGAGCTAAGAAGTATATTTGGGAATCTGTTGAACGAGAAGCAGCATTGAAACG TAAGAAAAATGATCCAAATGCAAGTTATTTTCCGAAGGGAGAACTATTAGTTTATGAACATTCATTAGGAAAATCCAATA CTAAAAAAGAGTTTCGATTGGCTTATAAATTTGGTATAGCCTCGATAGATCCACCAATATCGAGATACGTGTATGTGGAT TCTAACTCTGGGGAAATTCTATCCAGTAAAGATGCTAGAAGATACGAAGCGGGTGGAGGAGATACAATTCCAACGACTCC ACCAACTCCTCCGGATACAAATTACGGAATTTGTTTTCCGGATCAAACTCCTTGTATCAAACAAGGATCAGCGTCTACTC GTTTTAGCGGAGTGAAAACGATTACAACTTATACTGCAGGAGAAGAAAATCATTATGAACTGAAGGATTATTCGAGAGGT AAAGGAATCATTACGTATTCTTGGGAATTTATAGAAGATCCATTTATGGGTATTTATTTATTGAATGTTCCCATTGTTGA TATTAATAACGGTTGGACGAAATTTGAATATCATGACGATTATAATCATGATGCATTATTGGATGCACATTGGGGAATTG AAATGACGTATGATTATTTCAAATCCGTTCATAATCGGTTGAGTTATGATGGAAATGATAGCAAAGTAGTGAATAACGTG CACTATTTTAATATTTTCGTAGGTAATAATGCATACTGGGATCCTATGACAGAGGAAATCTATTATATATACTGTCCTCA TAACAGTAGTACATGCAAAAGTCTTAATTTACCTATTATTTTAGACCCTACATATGAAGATTTTACTTCTTTGGATATTG TATCTCATGAATTTGGACATGGTATCAACGGGGATCTTGCAGGTTTTACTTATGATCCAGAGCCAGGTGCTCTTGATGAA GGTTTTAGTGATATTTGGAATGTTGGTGTAAATAACTACGTAAATAAAGTTTTAGGAATGCAAAAGAACATTTGGTTAGT AGGAGATGAAACGGTTCCGGGAGGAGGAATGCGTTCTGTGTCAAATCCAAAATCTACTACAGTAATGTCCCCTGGGCCAA ATACGTATTATGGAGGTCTTTGGGATTCTGAAAATAACGAAGCGCATACGAATAGTCTTGTTTTGAGTCATTGGTTCTAT ACTTTATCCAAGGGAAAACAAGGGATCAATGATCATTGGTGTGAGTATAACGTTTCTGGAATCAACATTGAAAAGGCGGA AAAAATCGCTTATGCTGCTCTCTATTATCTTTTCCCTACATCCGGTTATACTTCTGCAAGGACCGCTGCGATTTATTCGG CTAAGGCTTTGTATGGTAAGTTTTCATCGGAAGTAAAAAGTACAATTGATGCTTGGGATGCAATAGGTGTTCCAGCTGAT ACAACTTCTCGCGGTGGACAAGGAATGTATAAGCCGCACTATTATATCACTTTTGTAAAACTTTCTAATTTAGAGAGAAG TTCCGGAAATGATTGTGGGTACAAGGATAATTCATACCTACATCCTACTGTCATTAAAGGATTTACGTATAACATGGTGT TATCGAGCGAAGGTGAGGTAAGTATTCCGTCTAAGGTTCACAAATGGAGAGTATGGATCGATTTCAATCGAAATGGTAGT TTTGAATCCTCGGAAATGGTAGTTCAGGATTCTATCAACGATACATTTGGAGGAACACTTCAAAAATCGATTCAGATTCC AACGAGTGCGCTTACTGGCGATACGAGGATGAGAGTTTCTATGAAGGCAGTCCAAAGCGGAGAAAGTTATCAACTTGCGA ATGAATCCTTTACCGAAGGAGAAGTTGAAGATTATTCGATAACTATCAATAATTTCAGTATTTAG
Upstream 100 bases:
>100_bases TATTTTTAGAATAACGGATTTTTAAATGATTATTTATATCTCGCTTAATGTTTAAGGGTTTTCGTAGAAGACAGATTTAA AATTAAAACAGAGGGATTGA
Downstream 100 bases:
>100_bases AAATCTCTAAAATAACTGCGAAAAGTTTCAAAATTGGATTAGATAGAATTAATCAATTTAGAACCTTTTTGCAGTTTGAA GTTCGAGTTTGTCTTAAAAT
Product: thermolysin precursor
Products: NA
Alternate protein names: Neutral protease [H]
Number of amino acids: Translated: 794; Mature: 794
Protein sequence:
>794_residues MRLLKLLKINSNIKILLSMFMISILFSCKDKQDPGMESWLWVLNPVQLDNKALSERTYTSDGRITFAKFNSDLVPYSRKQ APEVLKTYLQLPLTSQATFLRSARVGDFDHDRFQQRYKGVRVENGIYTVVSKENTIELMMGEFYQVPENFNSSPKLSESE ALSKTLKHIGAKKYIWESVEREAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD SNSGEILSSKDARRYEAGGGDTIPTTPPTPPDTNYGICFPDQTPCIKQGSASTRFSGVKTITTYTAGEENHYELKDYSRG KGIITYSWEFIEDPFMGIYLLNVPIVDINNGWTKFEYHDDYNHDALLDAHWGIEMTYDYFKSVHNRLSYDGNDSKVVNNV HYFNIFVGNNAYWDPMTEEIYYIYCPHNSSTCKSLNLPIILDPTYEDFTSLDIVSHEFGHGINGDLAGFTYDPEPGALDE GFSDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYYGGLWDSENNEAHTNSLVLSHWFY TLSKGKQGINDHWCEYNVSGINIEKAEKIAYAALYYLFPTSGYTSARTAAIYSAKALYGKFSSEVKSTIDAWDAIGVPAD TTSRGGQGMYKPHYYITFVKLSNLERSSGNDCGYKDNSYLHPTVIKGFTYNMVLSSEGEVSIPSKVHKWRVWIDFNRNGS FESSEMVVQDSINDTFGGTLQKSIQIPTSALTGDTRMRVSMKAVQSGESYQLANESFTEGEVEDYSITINNFSI
Sequences:
>Translated_794_residues MRLLKLLKINSNIKILLSMFMISILFSCKDKQDPGMESWLWVLNPVQLDNKALSERTYTSDGRITFAKFNSDLVPYSRKQ APEVLKTYLQLPLTSQATFLRSARVGDFDHDRFQQRYKGVRVENGIYTVVSKENTIELMMGEFYQVPENFNSSPKLSESE ALSKTLKHIGAKKYIWESVEREAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD SNSGEILSSKDARRYEAGGGDTIPTTPPTPPDTNYGICFPDQTPCIKQGSASTRFSGVKTITTYTAGEENHYELKDYSRG KGIITYSWEFIEDPFMGIYLLNVPIVDINNGWTKFEYHDDYNHDALLDAHWGIEMTYDYFKSVHNRLSYDGNDSKVVNNV HYFNIFVGNNAYWDPMTEEIYYIYCPHNSSTCKSLNLPIILDPTYEDFTSLDIVSHEFGHGINGDLAGFTYDPEPGALDE GFSDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYYGGLWDSENNEAHTNSLVLSHWFY TLSKGKQGINDHWCEYNVSGINIEKAEKIAYAALYYLFPTSGYTSARTAAIYSAKALYGKFSSEVKSTIDAWDAIGVPAD TTSRGGQGMYKPHYYITFVKLSNLERSSGNDCGYKDNSYLHPTVIKGFTYNMVLSSEGEVSIPSKVHKWRVWIDFNRNGS FESSEMVVQDSINDTFGGTLQKSIQIPTSALTGDTRMRVSMKAVQSGESYQLANESFTEGEVEDYSITINNFSI >Mature_794_residues MRLLKLLKINSNIKILLSMFMISILFSCKDKQDPGMESWLWVLNPVQLDNKALSERTYTSDGRITFAKFNSDLVPYSRKQ APEVLKTYLQLPLTSQATFLRSARVGDFDHDRFQQRYKGVRVENGIYTVVSKENTIELMMGEFYQVPENFNSSPKLSESE ALSKTLKHIGAKKYIWESVEREAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD SNSGEILSSKDARRYEAGGGDTIPTTPPTPPDTNYGICFPDQTPCIKQGSASTRFSGVKTITTYTAGEENHYELKDYSRG KGIITYSWEFIEDPFMGIYLLNVPIVDINNGWTKFEYHDDYNHDALLDAHWGIEMTYDYFKSVHNRLSYDGNDSKVVNNV HYFNIFVGNNAYWDPMTEEIYYIYCPHNSSTCKSLNLPIILDPTYEDFTSLDIVSHEFGHGINGDLAGFTYDPEPGALDE GFSDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYYGGLWDSENNEAHTNSLVLSHWFY TLSKGKQGINDHWCEYNVSGINIEKAEKIAYAALYYLFPTSGYTSARTAAIYSAKALYGKFSSEVKSTIDAWDAIGVPAD TTSRGGQGMYKPHYYITFVKLSNLERSSGNDCGYKDNSYLHPTVIKGFTYNMVLSSEGEVSIPSKVHKWRVWIDFNRNGS FESSEMVVQDSINDTFGGTLQKSIQIPTSALTGDTRMRVSMKAVQSGESYQLANESFTEGEVEDYSITINNFSI
Specific function: Extracellular zinc metalloprotease [H]
COG id: COG3227
COG function: function code E; Zinc metalloprotease (elastase)
Gene ontology:
Cell location: Secreted [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase M4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005075 - InterPro: IPR013856 - InterPro: IPR001570 - InterPro: IPR011096 [H]
Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]
EC number: =3.4.24.28 [H]
Molecular weight: Translated: 89633; Mature: 89633
Theoretical pI: Translated: 5.75; Mature: 5.75
Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00142 ZINC_PROTEASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLLKLLKINSNIKILLSMFMISILFSCKDKQDPGMESWLWVLNPVQLDNKALSERTYTS CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEECCEECCCHHHHCCEECC DGRITFAKFNSDLVPYSRKQAPEVLKTYLQLPLTSQATFLRSARVGDFDHDRFQQRYKGV CCCEEEEECCCCCCCCCHHCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCE RVENGIYTVVSKENTIELMMGEFYQVPENFNSSPKLSESEALSKTLKHIGAKKYIWESVE EECCCEEEEEECCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH REAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHEEEEEEECCCCCCCCCEEEEEEE SNSGEILSSKDARRYEAGGGDTIPTTPPTPPDTNYGICFPDQTPCIKQGSASTRFSGVKT CCCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEE ITTYTAGEENHYELKDYSRGKGIITYSWEFIEDPFMGIYLLNVPIVDINNGWTKFEYHDD EEEEECCCCCCEECCCCCCCCEEEEEEEHHHCCCCCEEEEEEEEEEECCCCEEEEEECCC YNHDALLDAHWGIEMTYDYFKSVHNRLSYDGNDSKVVNNVHYFNIFVGNNAYWDPMTEEI CCCCEEEEECCCEEEEHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCE YYIYCPHNSSTCKSLNLPIILDPTYEDFTSLDIVSHEFGHGINGDLAGFTYDPEPGALDE EEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCC GFSDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYYGGL CHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCEECCE WDSENNEAHTNSLVLSHWFYTLSKGKQGINDHWCEYNVSGINIEKAEKIAYAALYYLFPT ECCCCCCCHHHHEEHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHEEEEEEECC SGYTSARTAAIYSAKALYGKFSSEVKSTIDAWDAIGVPADTTSRGGQGMYKPHYYITFVK CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEE LSNLERSSGNDCGYKDNSYLHPTVIKGFTYNMVLSSEGEVSIPSKVHKWRVWIDFNRNGS EECCCCCCCCCCCCCCCCEECCCEECCEEEEEEEECCCCEECCCCCEEEEEEEEECCCCC FESSEMVVQDSINDTFGGTLQKSIQIPTSALTGDTRMRVSMKAVQSGESYQLANESFTEG CCCCCEEEECCCCCCCCCCCHHEEECCCHHCCCCCEEEEEEEHHHCCCCEEECCCCCCCC EVEDYSITINNFSI CCEEEEEEEEECCC >Mature Secondary Structure MRLLKLLKINSNIKILLSMFMISILFSCKDKQDPGMESWLWVLNPVQLDNKALSERTYTS CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEECCEECCCHHHHCCEECC DGRITFAKFNSDLVPYSRKQAPEVLKTYLQLPLTSQATFLRSARVGDFDHDRFQQRYKGV CCCEEEEECCCCCCCCCHHCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCE RVENGIYTVVSKENTIELMMGEFYQVPENFNSSPKLSESEALSKTLKHIGAKKYIWESVE EECCCEEEEEECCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH REAALKRKKNDPNASYFPKGELLVYEHSLGKSNTKKEFRLAYKFGIASIDPPISRYVYVD HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHEEEEEEECCCCCCCCCEEEEEEE SNSGEILSSKDARRYEAGGGDTIPTTPPTPPDTNYGICFPDQTPCIKQGSASTRFSGVKT CCCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEE ITTYTAGEENHYELKDYSRGKGIITYSWEFIEDPFMGIYLLNVPIVDINNGWTKFEYHDD EEEEECCCCCCEECCCCCCCCEEEEEEEHHHCCCCCEEEEEEEEEEECCCCEEEEEECCC YNHDALLDAHWGIEMTYDYFKSVHNRLSYDGNDSKVVNNVHYFNIFVGNNAYWDPMTEEI CCCCEEEEECCCEEEEHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCE YYIYCPHNSSTCKSLNLPIILDPTYEDFTSLDIVSHEFGHGINGDLAGFTYDPEPGALDE EEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCC GFSDIWNVGVNNYVNKVLGMQKNIWLVGDETVPGGGMRSVSNPKSTTVMSPGPNTYYGGL CHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCEECCE WDSENNEAHTNSLVLSHWFYTLSKGKQGINDHWCEYNVSGINIEKAEKIAYAALYYLFPT ECCCCCCCHHHHEEHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHEEEEEEECC SGYTSARTAAIYSAKALYGKFSSEVKSTIDAWDAIGVPADTTSRGGQGMYKPHYYITFVK CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEE LSNLERSSGNDCGYKDNSYLHPTVIKGFTYNMVLSSEGEVSIPSKVHKWRVWIDFNRNGS EECCCCCCCCCCCCCCCCEECCCEECCEEEEEEEECCCCEECCCCCEEEEEEEEECCCCC FESSEMVVQDSINDTFGGTLQKSIQIPTSALTGDTRMRVSMKAVQSGESYQLANESFTEG CCCCCEEEECCCCCCCCCCCHHEEECCCHHCCCCCEEEEEEEHHHCCCCEEECCCCCCCC EVEDYSITINNFSI CCEEEEEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2203733; 3149972 [H]