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The map label for this gene is hslU

Identifier: 45657473

GI number: 45657473

Start: 1960079

End: 1961518

Strand: Direct

Name: hslU

Synonym: LIC11601

Alternate gene names: 45657473

Gene position: 1960079-1961518 (Clockwise)

Preceding gene: 45657472

Following gene: 45657474

Centisome position: 45.83

GC content: 39.44

Gene sequence:

>1440_bases
ATGGCAAATCATCCAATAGACCAGGAACTTACATCACCGGCAGAAGAAGAGCTTACGCCTAGAGAAATCGTAGCAAAATT
AGACGAACATATAATCAGTCAAAAAAACGCAAAGAAGGCAGTAGCCATCGCTCTTAGAAACAGGACCAGACGTAAAAAAT
TGGATCCGGAAATGAGAGAGGAAATTTACCCTAAGAACATCATCATGATTGGGCCCACCGGGGTCGGAAAAACGGAAATC
GCAAGAAGGCTTTCTAAACTCTGTGGTGCTCCCTTTTTAAAAGTAGAAGCTACTAAATATACGGAAGTAGGTTACGTTGG
GAGAGACGTAGAATCTATGATTCGTGATCTTGCTGTAATTTCTATGAATCTTGTAAAACAAGAATTTAGAACTAAAGTAG
AAGAAACTGCAAAACAAAAAGCGGAAGAAGCATTACTCGACATTCTTCTTCCTTTTCCCGGCGAAAATAAACACGGTTCT
GGACAGATAACCGGCTTTGCCACCTCATCGACGTTAGCTGATGAAGAGGATAGAAAAACTCATTTTCTGGAAACCAGAGA
ATTTATGAGAAAGAAATTAAAAACCGGAAAGTTGGATGATCAGGAAGTAGAACTAGATCTTCCAAATCCGAGTGTCTCTC
AGGTTCCTATGCTTCAAGTTTTTGGTGCGGGAAATTTAGACGACCTTGACAATCAACTTCAAAACGTTTTAGGAGATATA
CTTCCTAAAAAAAATAAAAAAAGGAAACTTAAAATCCCTGAAGCTTTAAAAGCTTTAGAGGAATCCGAAGCAGAAAAGCT
TCTCGATCCTGATAAAGTACAAAGAGAAGCACTTCGAAGAGTAGAAGAAATGGGAATCATATTTTTAGACGAGATCGATA
AGATTGCTGGAAGAGAAGGAAAAAGTGGGGCGGACGTTTCTAGAGAAGGAGTTCAAAGAGATCTTCTCCCTATCGTAGAA
GGAGCTACGGTAAACACAAAGATCGGTCCGGTAAAAACGGATCATATTTTGTTTATCGCTGCAGGTGCGTTTCACATGAC
AAAACCTTCCGATCTCATTCCTGAATTGCAGGGAAGATTTCCGATTCGAGTGGAACTCGAAAAACTTTCGAGAGAAGATT
TTGAAAAAATTCTTACCGCACCTCGTTCTTCTCTTACAAGACAATACGAGGCTCTACTTTCTACCGATGGAATTCAGTTG
GAATTTTCTTTGGACGGAATTCAAGAAATTGCAAGAATCGCCTACGATATGAATGAAAAACACGAAAATATTGGTGCCAG
AAGACTCAATACAATTTTAGAACGTCTTCTTGAAGAAGTGAGCTTTGAAGGTCCAGATCTTCCGGAGAGTCAGAGAAAAG
TAAGGATAGACGGTAAATACGTTACCGATCGCCTGCAAGGTGTGATTCAAAATAAAGATCTGAGTCAGTATATTCTTTAA

Upstream 100 bases:

>100_bases
TCCCAAAGAGATAGTAGAGTCTTCGATGAAGATTGCGGCGGATATTTGTATTTATACAAACAATCATATAACCCTAGAAG
AAATTCTTTAAAATAAAAGT

Downstream 100 bases:

>100_bases
ATAAGTTTTTCTAATATAATAAGTTTTTAATCTCAAAGTAGTGACCCGTGTGGAAAAATTGATTTTTTTTGAAATTTTTA
TGAAATCTAAAAATAACAAT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MANHPIDQELTSPAEEELTPREIVAKLDEHIISQKNAKKAVAIALRNRTRRKKLDPEMREEIYPKNIIMIGPTGVGKTEI
ARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVISMNLVKQEFRTKVEETAKQKAEEALLDILLPFPGENKHGS
GQITGFATSSTLADEEDRKTHFLETREFMRKKLKTGKLDDQEVELDLPNPSVSQVPMLQVFGAGNLDDLDNQLQNVLGDI
LPKKNKKRKLKIPEALKALEESEAEKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKSGADVSREGVQRDLLPIVE
GATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPIRVELEKLSREDFEKILTAPRSSLTRQYEALLSTDGIQL
EFSLDGIQEIARIAYDMNEKHENIGARRLNTILERLLEEVSFEGPDLPESQRKVRIDGKYVTDRLQGVIQNKDLSQYIL

Sequences:

>Translated_479_residues
MANHPIDQELTSPAEEELTPREIVAKLDEHIISQKNAKKAVAIALRNRTRRKKLDPEMREEIYPKNIIMIGPTGVGKTEI
ARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVISMNLVKQEFRTKVEETAKQKAEEALLDILLPFPGENKHGS
GQITGFATSSTLADEEDRKTHFLETREFMRKKLKTGKLDDQEVELDLPNPSVSQVPMLQVFGAGNLDDLDNQLQNVLGDI
LPKKNKKRKLKIPEALKALEESEAEKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKSGADVSREGVQRDLLPIVE
GATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPIRVELEKLSREDFEKILTAPRSSLTRQYEALLSTDGIQL
EFSLDGIQEIARIAYDMNEKHENIGARRLNTILERLLEEVSFEGPDLPESQRKVRIDGKYVTDRLQGVIQNKDLSQYIL
>Mature_478_residues
ANHPIDQELTSPAEEELTPREIVAKLDEHIISQKNAKKAVAIALRNRTRRKKLDPEMREEIYPKNIIMIGPTGVGKTEIA
RRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVISMNLVKQEFRTKVEETAKQKAEEALLDILLPFPGENKHGSG
QITGFATSSTLADEEDRKTHFLETREFMRKKLKTGKLDDQEVELDLPNPSVSQVPMLQVFGAGNLDDLDNQLQNVLGDIL
PKKNKKRKLKIPEALKALEESEAEKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREGKSGADVSREGVQRDLLPIVEG
ATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRFPIRVELEKLSREDFEKILTAPRSSLTRQYEALLSTDGIQLE
FSLDGIQEIARIAYDMNEKHENIGARRLNTILERLLEEVSFEGPDLPESQRKVRIDGKYVTDRLQGVIQNKDLSQYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=95, Percent_Identity=40, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790366, Length=464, Percent_Identity=52.1551724137931, Blast_Score=473, Evalue=1e-135,
Organism=Escherichia coli, GI1786642, Length=100, Percent_Identity=45, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319704, Length=108, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648291, Length=247, Percent_Identity=31.9838056680162, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24648289, Length=247, Percent_Identity=31.9838056680162, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_LEPIC (Q72RY7)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001559.1
- ProteinModelPortal:   Q72RY7
- SMR:   Q72RY7
- GeneID:   2771372
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11601
- NMPDR:   fig|267671.1.peg.1559
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- ProtClustDB:   PRK05201
- BioCyc:   LINT267671:LIC_11601-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR011704
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF07724 AAA_2; PF07728 AAA_5; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 54042; Mature: 53911

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: BINDING 32-32 BINDING 290-290 BINDING 355-355 BINDING 427-427

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHPIDQELTSPAEEELTPREIVAKLDEHIISQKNAKKAVAIALRNRTRRKKLDPEMRE
CCCCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHH
EIYPKNIIMIGPTGVGKTEIARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVI
HCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHH
SMNLVKQEFRTKVEETAKQKAEEALLDILLPFPGENKHGSGQITGFATSSTLADEEDRKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHH
HFLETREFMRKKLKTGKLDDQEVELDLPNPSVSQVPMLQVFGAGNLDDLDNQLQNVLGDI
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHH
LPKKNKKRKLKIPEALKALEESEAEKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
KSGADVSREGVQRDLLPIVEGATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRF
CCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCC
PIRVELEKLSREDFEKILTAPRSSLTRQYEALLSTDGIQLEFSLDGIQEIARIAYDMNEK
CEEEEHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHH
HENIGARRLNTILERLLEEVSFEGPDLPESQRKVRIDGKYVTDRLQGVIQNKDLSQYIL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
ANHPIDQELTSPAEEELTPREIVAKLDEHIISQKNAKKAVAIALRNRTRRKKLDPEMRE
CCCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHH
EIYPKNIIMIGPTGVGKTEIARRLSKLCGAPFLKVEATKYTEVGYVGRDVESMIRDLAVI
HCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHH
SMNLVKQEFRTKVEETAKQKAEEALLDILLPFPGENKHGSGQITGFATSSTLADEEDRKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHH
HFLETREFMRKKLKTGKLDDQEVELDLPNPSVSQVPMLQVFGAGNLDDLDNQLQNVLGDI
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHH
LPKKNKKRKLKIPEALKALEESEAEKLLDPDKVQREALRRVEEMGIIFLDEIDKIAGREG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
KSGADVSREGVQRDLLPIVEGATVNTKIGPVKTDHILFIAAGAFHMTKPSDLIPELQGRF
CCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCC
PIRVELEKLSREDFEKILTAPRSSLTRQYEALLSTDGIQLEFSLDGIQEIARIAYDMNEK
CEEEEHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHH
HENIGARRLNTILERLLEEVSFEGPDLPESQRKVRIDGKYVTDRLQGVIQNKDLSQYIL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA