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The map label for this gene is map

Identifier: 45657375

GI number: 45657375

Start: 1850713

End: 1851471

Strand: Direct

Name: map

Synonym: LIC11500

Alternate gene names: 45657375

Gene position: 1850713-1851471 (Clockwise)

Preceding gene: 45657374

Following gene: 45657376

Centisome position: 43.27

GC content: 40.97

Gene sequence:

>759_bases
TTGATCTTTATTAAGAACAAGAGCGAAATCGAAAAAATGAGAGCGGCTGGGAAACTGGCCGCTAGGCTTTTGGATTATAT
TTCCTCTTACGTTCAACCGGGTGTTTCTACTTTGCAGTTGAACGATCTTTGTGAGGAGTTTACTAAAAAGCACGGGGCAA
GATCCGCCCCGCTCGGTTATAAAGGATTTCCTAAGTCGATCTGTACATCTGTAAATCAAGTTGTATGTCATGGAATTCCC
AAAGCAAATGAAGTTTTAAAAGAAGGGGACATCATCAACATAGATGTAACTCCTATTTTAGATGGTTATCATGGGGATTC
ATCTCGTACGTTTATCGTAGGAGGTAATACAAGTTCTGAGGTTAAAACTCTAGTTCAAGATACCGAGAAAGCGATGTTTA
TCGGTATCGAACAAGTGCGGCCTGGAAATCGTGTTCATGATATTGCAAATGCAATCGATGATTTTCTTACTCCTAAAGGG
TACGGAATTGTAAGAGATCTAATGGGGCACGGAATTGGAAGAGGTTTTCATGAAGATCCTCAGATTCCCCATTTTCGTCA
GAATCGTAAACTCGCTAAGCTAGAACCTGGAATGGTATTTACTGTGGAGCCGATGGTGAATTTGGGAACTTGGCAGGTAA
ACTTTTCTAAAGAAGATCATTGGACCGTGACTACAAGGGACGGTAAATGGTCCGCTCAATTTGAGCATACGGTTCTAGTC
ACCGAAAAAGGCTATGAAATTTTAACCGTATCCGATTAA

Upstream 100 bases:

>100_bases
CGGTTTGAATGAAAAAATTCACCAACTGATCGACGATGCGGTGAAACGCACTGAATCCAATAAAAGAAGTACTGTTCGCC
CGACAGATTTCTAATTCGAT

Downstream 100 bases:

>100_bases
TCTGTCGTTCATGGAAATGATACTTGGTTATCTGAGTGTTTTGGGTAGAGACGCAGTATTTTTTTTAATCAGTTTTATTC
TATTTTATATTGGTAAAAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIFIKNKSEIEKMRAAGKLAARLLDYISSYVQPGVSTLQLNDLCEEFTKKHGARSAPLGYKGFPKSICTSVNQVVCHGIP
KANEVLKEGDIINIDVTPILDGYHGDSSRTFIVGGNTSSEVKTLVQDTEKAMFIGIEQVRPGNRVHDIANAIDDFLTPKG
YGIVRDLMGHGIGRGFHEDPQIPHFRQNRKLAKLEPGMVFTVEPMVNLGTWQVNFSKEDHWTVTTRDGKWSAQFEHTVLV
TEKGYEILTVSD

Sequences:

>Translated_252_residues
MIFIKNKSEIEKMRAAGKLAARLLDYISSYVQPGVSTLQLNDLCEEFTKKHGARSAPLGYKGFPKSICTSVNQVVCHGIP
KANEVLKEGDIINIDVTPILDGYHGDSSRTFIVGGNTSSEVKTLVQDTEKAMFIGIEQVRPGNRVHDIANAIDDFLTPKG
YGIVRDLMGHGIGRGFHEDPQIPHFRQNRKLAKLEPGMVFTVEPMVNLGTWQVNFSKEDHWTVTTRDGKWSAQFEHTVLV
TEKGYEILTVSD
>Mature_252_residues
MIFIKNKSEIEKMRAAGKLAARLLDYISSYVQPGVSTLQLNDLCEEFTKKHGARSAPLGYKGFPKSICTSVNQVVCHGIP
KANEVLKEGDIINIDVTPILDGYHGDSSRTFIVGGNTSSEVKTLVQDTEKAMFIGIEQVRPGNRVHDIANAIDDFLTPKG
YGIVRDLMGHGIGRGFHEDPQIPHFRQNRKLAKLEPGMVFTVEPMVNLGTWQVNFSKEDHWTVTTRDGKWSAQFEHTVLV
TEKGYEILTVSD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=248, Percent_Identity=42.3387096774194, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=41.1290322580645, Blast_Score=181, Evalue=6e-46,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=49.2, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1788728, Length=250, Percent_Identity=28.4, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996291, Length=252, Percent_Identity=40.0793650793651, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=44.6215139442231, Blast_Score=232, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=45.1612903225806, Blast_Score=215, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=43.0894308943089, Blast_Score=194, Evalue=5e-50,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28058; Mature: 28058

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFIKNKSEIEKMRAAGKLAARLLDYISSYVQPGVSTLQLNDLCEEFTKKHGARSAPLGY
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
KGFPKSICTSVNQVVCHGIPKANEVLKEGDIINIDVTPILDGYHGDSSRTFIVGGNTSSE
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECCCHHH
VKTLVQDTEKAMFIGIEQVRPGNRVHDIANAIDDFLTPKGYGIVRDLMGHGIGRGFHEDP
HHHHHHHHHHHEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
QIPHFRQNRKLAKLEPGMVFTVEPMVNLGTWQVNFSKEDHWTVTTRDGKWSAQFEHTVLV
CCCCHHCCCCEEEECCCEEEEECCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEEEEEE
TEKGYEILTVSD
EECCEEEEEECC
>Mature Secondary Structure
MIFIKNKSEIEKMRAAGKLAARLLDYISSYVQPGVSTLQLNDLCEEFTKKHGARSAPLGY
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
KGFPKSICTSVNQVVCHGIPKANEVLKEGDIINIDVTPILDGYHGDSSRTFIVGGNTSSE
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECCCHHH
VKTLVQDTEKAMFIGIEQVRPGNRVHDIANAIDDFLTPKGYGIVRDLMGHGIGRGFHEDP
HHHHHHHHHHHEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
QIPHFRQNRKLAKLEPGMVFTVEPMVNLGTWQVNFSKEDHWTVTTRDGKWSAQFEHTVLV
CCCCHHCCCCEEEECCCEEEEECCCCCCCEEEEEECCCCCEEEEECCCCEEEEEEEEEEE
TEKGYEILTVSD
EECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]