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The map label for this gene is tkt

Identifier: 45657233

GI number: 45657233

Start: 1669086

End: 1670048

Strand: Direct

Name: tkt

Synonym: LIC11355

Alternate gene names: 45657233

Gene position: 1669086-1670048 (Clockwise)

Preceding gene: 161621776

Following gene: 45657234

Centisome position: 39.02

GC content: 41.23

Gene sequence:

>963_bases
ATGGGAGCTCCAAGCACATCGACTGCGACTGAAAAAGCTACTCGTGATGGTTATGGAGACGCGCTGCATGAATTAGGTGC
TTCTCGTCCGGATGTGGTCGTTTTAGATGCAGATCTTTCTGGATCTACAAAAACCAATAAGTTTGCGAAAGCTTTTCCAG
ATCGTTTTTTTAACGTAGGTGTCGCTGAACAGAACTTAGTTGGTCACGCAGCCGGTTTGGCGCTTTCAGGACTTGTTCCA
TTTGCTTCTTCTTTTGCAATGTTTCTTTCAGGAAGAGCTTGGGAAATTGTTCGAAATAGTGTGGTTTATCCATTTTTAAA
TGTAAAGCTGGTTGCTTCTCATGGAGGAATTACCGTAGGTGAGGACGGGGCTTCTCATCAATGTATCGAAGACTTTGCGA
TTATGAGGGTCATTCCTGAAATGACTGTAATCTGTCCTTCGGACTACAACGAATGCAAACAGATAATTCATGCAATCGCC
GACTATAAAGGTCCGGTCTATGTTCGAGTAGGACGTCCCAATGTTCCTATTATCGAAAGAGAAAATTATAAGTTTCAAAT
CGGAAAAGCGGAAGTGATGAGAGAAGGTAAGGATGTACTCATCATCGCTAATGGGGTTCTTGTAAACGAGGCGATCAAAG
CATCGGAAGAATTGTCCAAGGAAGGAATTCAAGTGACTCTTTTGAACATGGCTACGATCAAACCAATCGATAAGGAAACA
ATTTTAAAATACGCTAAAGAATGTGGGATAGTAGTCACTTGCGAGGAACATAACGTGGTCGGTGGACTTGGTTCCGCAGT
TAGCGAATTTTTATCGGAAGAATATCCAGTTCACGTTTTAAAAGTGGGTATGAAAGATCAATTTGGAAAGTCCGGAACTT
GGAAGGAACTTTTAGATTATTTTGGTCTTCGTTCTAAAAATATCGTTGAAACTGTGAAGAAGGCGAAGACTCTCAAAAAA
TAA

Upstream 100 bases:

>100_bases
TATAGAGAAACCGCTTCTTATGGGCATTTCGGAAGAAAGGGTTCCACTTTTACTTGGGAAGAAACCGACAAAGCCTCTGC
TTTAAAAGGATAATATAAAA

Downstream 100 bases:

>100_bases
AATTCTAGATCGGTGAGAATGAAATTTCATATAATCTTTTTTCTTTTTCAAAGAGCGAAGATTTTTGTAAGAAAAGAAAT
TTTTCTTACACTCATTTCTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MGAPSTSTATEKATRDGYGDALHELGASRPDVVVLDADLSGSTKTNKFAKAFPDRFFNVGVAEQNLVGHAAGLALSGLVP
FASSFAMFLSGRAWEIVRNSVVYPFLNVKLVASHGGITVGEDGASHQCIEDFAIMRVIPEMTVICPSDYNECKQIIHAIA
DYKGPVYVRVGRPNVPIIERENYKFQIGKAEVMREGKDVLIIANGVLVNEAIKASEELSKEGIQVTLLNMATIKPIDKET
ILKYAKECGIVVTCEEHNVVGGLGSAVSEFLSEEYPVHVLKVGMKDQFGKSGTWKELLDYFGLRSKNIVETVKKAKTLKK

Sequences:

>Translated_320_residues
MGAPSTSTATEKATRDGYGDALHELGASRPDVVVLDADLSGSTKTNKFAKAFPDRFFNVGVAEQNLVGHAAGLALSGLVP
FASSFAMFLSGRAWEIVRNSVVYPFLNVKLVASHGGITVGEDGASHQCIEDFAIMRVIPEMTVICPSDYNECKQIIHAIA
DYKGPVYVRVGRPNVPIIERENYKFQIGKAEVMREGKDVLIIANGVLVNEAIKASEELSKEGIQVTLLNMATIKPIDKET
ILKYAKECGIVVTCEEHNVVGGLGSAVSEFLSEEYPVHVLKVGMKDQFGKSGTWKELLDYFGLRSKNIVETVKKAKTLKK
>Mature_319_residues
GAPSTSTATEKATRDGYGDALHELGASRPDVVVLDADLSGSTKTNKFAKAFPDRFFNVGVAEQNLVGHAAGLALSGLVPF
ASSFAMFLSGRAWEIVRNSVVYPFLNVKLVASHGGITVGEDGASHQCIEDFAIMRVIPEMTVICPSDYNECKQIIHAIAD
YKGPVYVRVGRPNVPIIERENYKFQIGKAEVMREGKDVLIIANGVLVNEAIKASEELSKEGIQVTLLNMATIKPIDKETI
LKYAKECGIVVTCEEHNVVGGLGSAVSEFLSEEYPVHVLKVGMKDQFGKSGTWKELLDYFGLRSKNIVETVKKAKTLKK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=314, Percent_Identity=37.5796178343949, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4507521, Length=314, Percent_Identity=37.5796178343949, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI225637463, Length=316, Percent_Identity=37.9746835443038, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI225637459, Length=316, Percent_Identity=37.9746835443038, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI225637461, Length=316, Percent_Identity=37.9746835443038, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI133778974, Length=314, Percent_Identity=36.624203821656, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI4557353, Length=245, Percent_Identity=26.9387755102041, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI34101272, Length=245, Percent_Identity=26.9387755102041, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI291084858, Length=246, Percent_Identity=25.609756097561, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI156564403, Length=253, Percent_Identity=25.6916996047431, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=299, Percent_Identity=36.1204013377926, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI48994911, Length=335, Percent_Identity=26.2686567164179, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788808, Length=338, Percent_Identity=26.0355029585799, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539652, Length=317, Percent_Identity=39.7476340694006, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6325331, Length=342, Percent_Identity=23.3918128654971, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319593, Length=200, Percent_Identity=26.5, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=346, Percent_Identity=23.9884393063584, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24645119, Length=315, Percent_Identity=35.8730158730159, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI45551847, Length=315, Percent_Identity=35.8730158730159, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI45550715, Length=315, Percent_Identity=35.8730158730159, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24666278, Length=309, Percent_Identity=35.5987055016181, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358145, Length=285, Percent_Identity=25.9649122807018, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650940, Length=285, Percent_Identity=25.9649122807018, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI160714832, Length=267, Percent_Identity=26.5917602996255, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI160714828, Length=239, Percent_Identity=27.6150627615063, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34782; Mature: 34651

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPSTSTATEKATRDGYGDALHELGASRPDVVVLDADLSGSTKTNKFAKAFPDRFFNVG
CCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCC
VAEQNLVGHAAGLALSGLVPFASSFAMFLSGRAWEIVRNSVVYPFLNVKLVASHGGITVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEEEEECCCCEEEC
EDGASHQCIEDFAIMRVIPEMTVICPSDYNECKQIIHAIADYKGPVYVRVGRPNVPIIER
CCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEC
ENYKFQIGKAEVMREGKDVLIIANGVLVNEAIKASEELSKEGIQVTLLNMATIKPIDKET
CCCEEEECHHHHHHCCCCEEEEECCEEHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHH
ILKYAKECGIVVTCEEHNVVGGLGSAVSEFLSEEYPVHVLKVGMKDQFGKSGTWKELLDY
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCHHHHHHH
FGLRSKNIVETVKKAKTLKK
HCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
GAPSTSTATEKATRDGYGDALHELGASRPDVVVLDADLSGSTKTNKFAKAFPDRFFNVG
CCCCCCCHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCC
VAEQNLVGHAAGLALSGLVPFASSFAMFLSGRAWEIVRNSVVYPFLNVKLVASHGGITVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEEEEECCCCEEEC
EDGASHQCIEDFAIMRVIPEMTVICPSDYNECKQIIHAIADYKGPVYVRVGRPNVPIIER
CCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEC
ENYKFQIGKAEVMREGKDVLIIANGVLVNEAIKASEELSKEGIQVTLLNMATIKPIDKET
CCCEEEECHHHHHHCCCCEEEEECCEEHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHH
ILKYAKECGIVVTCEEHNVVGGLGSAVSEFLSEEYPVHVLKVGMKDQFGKSGTWKELLDY
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCHHHHHHH
FGLRSKNIVETVKKAKTLKK
HCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]