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The map label for this gene is lepB [H]

Identifier: 45657116

GI number: 45657116

Start: 1526494

End: 1527495

Strand: Direct

Name: lepB [H]

Synonym: LIC11233

Alternate gene names: 45657116

Gene position: 1526494-1527495 (Clockwise)

Preceding gene: 45657113

Following gene: 45657117

Centisome position: 35.69

GC content: 39.02

Gene sequence:

>1002_bases
ATGAAGTTAGAATCCGAGGTCAAAACAAAAGAGTCTTCTGCTGGGCAGGAATCTCCCATTAGTTCTACATTTTCCTTTAT
TCTGATCGTGATCCTGGTATTTGCTTTTAAATCCTCGGTTTTAGACGCGAATAATATACCGTCTGGATCTATGATCCCCA
CCTTAAAAATTGGGGATTTTCTATTCGTAAATAAGATGAGATATTCGATTCGAATGCCATTTACAGAGTCGGAATTGATA
CGAATCGACGATCCTCAACGAGGAGATATAGTCACTTTTGCGCCACCATTTCGTGCCTTAAGTCTTGGAGACAGTCGGGA
TGGATTTTTTGCAAAACGTTACGTGAAACGAGTAGTGGGTCTTCCGGGTGATACGATTCGGATCACTTCTAAATTTCTAT
CCACAAAAAAAGGAGACGTGAATTATTCCGTCATCGAATACAAAGAAAAAGGATCTGATAGATTTCAAGGTTACGATCCT
GTGGAAACAGAAGAGGGGAATGTATTGGGAGATTTGGACAATCTCTATGCTCCTACAAGATCACTATTTTTAGAAAAAAA
ACCTGGTTTTGAACACTACGTCTTAGAAGGTTATGAAGAAGATCGCAAACGACTCGATGGATATGAATGTAATTTTTCGA
TCGGATGTGAAATTCCTGAAAATCAATATATGGTCGTAGGAGACAACCGAGACGATTCTCACGATTCCAGAACTTGGGGA
TTTGTTAAAAGAGAAGATATACTCGGAAAGGCTTTAGTGATTTATTTTTCCATCAATTGGAAAGATAACGTCTGCGAATA
TAAGAATGGAAAGGAACTATCTGAAAAAGGACCTGAATTTGCGGAACGTTATCAGGGGGAAGAACTTGTAAAACATTGTC
ATCCTTCCGAAATCGGTTTGGTAAGAGAAGAAAGTAAACTTGGCTGGGTGGAACGTACTCTTCGTTATCGAATTTGGAGA
ATGGAAGTTCGTTGGAATCGTATCGGAAAGATTTTACGTTAG

Upstream 100 bases:

>100_bases
ATCTGTTCTTTCACAATCAAAGTATCGGTGATTTTTGAAAAACCGATAGAATTTTTAACGCAGGATTGACAGGGGAGAGA
AGATTCTTTTTGCTTTCCCT

Downstream 100 bases:

>100_bases
TCGCCATGTCTGAAGAAAATGACGAAGGTAAAAAAAACGATACTTCTGATTTTCAGAAAGAAACTAAACCAAAACAGAAA
GAAATTTCACCTTGGGAGTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKLESEVKTKESSAGQESPISSTFSFILIVILVFAFKSSVLDANNIPSGSMIPTLKIGDFLFVNKMRYSIRMPFTESELI
RIDDPQRGDIVTFAPPFRALSLGDSRDGFFAKRYVKRVVGLPGDTIRITSKFLSTKKGDVNYSVIEYKEKGSDRFQGYDP
VETEEGNVLGDLDNLYAPTRSLFLEKKPGFEHYVLEGYEEDRKRLDGYECNFSIGCEIPENQYMVVGDNRDDSHDSRTWG
FVKREDILGKALVIYFSINWKDNVCEYKNGKELSEKGPEFAERYQGEELVKHCHPSEIGLVREESKLGWVERTLRYRIWR
MEVRWNRIGKILR

Sequences:

>Translated_333_residues
MKLESEVKTKESSAGQESPISSTFSFILIVILVFAFKSSVLDANNIPSGSMIPTLKIGDFLFVNKMRYSIRMPFTESELI
RIDDPQRGDIVTFAPPFRALSLGDSRDGFFAKRYVKRVVGLPGDTIRITSKFLSTKKGDVNYSVIEYKEKGSDRFQGYDP
VETEEGNVLGDLDNLYAPTRSLFLEKKPGFEHYVLEGYEEDRKRLDGYECNFSIGCEIPENQYMVVGDNRDDSHDSRTWG
FVKREDILGKALVIYFSINWKDNVCEYKNGKELSEKGPEFAERYQGEELVKHCHPSEIGLVREESKLGWVERTLRYRIWR
MEVRWNRIGKILR
>Mature_333_residues
MKLESEVKTKESSAGQESPISSTFSFILIVILVFAFKSSVLDANNIPSGSMIPTLKIGDFLFVNKMRYSIRMPFTESELI
RIDDPQRGDIVTFAPPFRALSLGDSRDGFFAKRYVKRVVGLPGDTIRITSKFLSTKKGDVNYSVIEYKEKGSDRFQGYDP
VETEEGNVLGDLDNLYAPTRSLFLEKKPGFEHYVLEGYEEDRKRLDGYECNFSIGCEIPENQYMVVGDNRDDSHDSRTWG
FVKREDILGKALVIYFSINWKDNVCEYKNGKELSEKGPEFAERYQGEELVKHCHPSEIGLVREESKLGWVERTLRYRIWR
MEVRWNRIGKILR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=289, Percent_Identity=31.8339100346021, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 38432; Mature: 38432

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLESEVKTKESSAGQESPISSTFSFILIVILVFAFKSSVLDANNIPSGSMIPTLKIGDF
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCE
LFVNKMRYSIRMPFTESELIRIDDPQRGDIVTFAPPFRALSLGDSRDGFFAKRYVKRVVG
EEEEEEEEEEECCCCCCCEEEECCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHC
LPGDTIRITSKFLSTKKGDVNYSVIEYKEKGSDRFQGYDPVETEEGNVLGDLDNLYAPTR
CCCCEEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHCCHH
SLFLEKKPGFEHYVLEGYEEDRKRLDGYECNFSIGCEIPENQYMVVGDNRDDSHDSRTWG
HHEEECCCCCCHHHHCCCHHHHHHCCCEECCEEEECCCCCCCEEEEECCCCCCCCCCCCC
FVKREDILGKALVIYFSINWKDNVCEYKNGKELSEKGPEFAERYQGEELVKHCHPSEIGL
CEEHHHHCCEEEEEEEEECCCCCCCCCCCCCCHHHCCHHHHHHCCHHHHHHHCCCCCCCE
VREESKLGWVERTLRYRIWRMEVRWNRIGKILR
EECCHHHHHHHHHHHHEEEEEEEEHHHHHHHCC
>Mature Secondary Structure
MKLESEVKTKESSAGQESPISSTFSFILIVILVFAFKSSVLDANNIPSGSMIPTLKIGDF
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCE
LFVNKMRYSIRMPFTESELIRIDDPQRGDIVTFAPPFRALSLGDSRDGFFAKRYVKRVVG
EEEEEEEEEEECCCCCCCEEEECCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHC
LPGDTIRITSKFLSTKKGDVNYSVIEYKEKGSDRFQGYDPVETEEGNVLGDLDNLYAPTR
CCCCEEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHCCHH
SLFLEKKPGFEHYVLEGYEEDRKRLDGYECNFSIGCEIPENQYMVVGDNRDDSHDSRTWG
HHEEECCCCCCHHHHCCCHHHHHHCCCEECCEEEECCCCCCCEEEEECCCCCCCCCCCCC
FVKREDILGKALVIYFSINWKDNVCEYKNGKELSEKGPEFAERYQGEELVKHCHPSEIGL
CEEHHHHCCEEEEEEEEECCCCCCCCCCCCCCHHHCCHHHHHHCCHHHHHHHCCCCCCCE
VREESKLGWVERTLRYRIWRMEVRWNRIGKILR
EECCHHHHHHHHHHHHEEEEEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]