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The map label for this gene is purM

Identifier: 45657007

GI number: 45657007

Start: 1386807

End: 1387808

Strand: Direct

Name: purM

Synonym: LIC11123

Alternate gene names: 45657007

Gene position: 1386807-1387808 (Clockwise)

Preceding gene: 45657006

Following gene: 45657008

Centisome position: 32.42

GC content: 38.92

Gene sequence:

>1002_bases
GTGGATACCGAAAAAGGAAGAGAGTTCATACAAAAAATCAAACGTAACGTAGAATCTACTCACGGGCCGAGGGTAATCGG
TGGTCTGGGCGGTTTTGCAGGAGCTTATGATGTAAGCGTTCTTAAAAAATACAAACACCCGATTTTATTGTCCGGAACGG
ATGGGGTAGGAACAAAAATAGAACTCGCTCGACTTCTAAAAATTTACAACACAATAGGAATTGATCTAGTGGCGATGTGT
GTGAACGACATACTTGTCTGCGGAGGAGAACCGTTTTTCTTTTTAGATTATATCGCCTGTGGAAAATTAGATCCTGAAAA
GATGGATCAGATCGTATCCGGAATTGTACAAGGATGCAAAATGTCTAATGCGTCTTTATTAGGAGGAGAAACCGCCGAAC
ATCCAGGAACGATGAAAGAGGATGAATTTGATCTCGCCGGTTTTGTAGTCGGGGCGGTTGAAAAAGATTCAATGATAGAC
GGTTCTACAATTCGATCTGGAGATAAAATTTTAGGACTCGAATCCAGTGGACCGCATAGCAACGGCTTTTCTCTCATTCG
TAAACTACTTTTAAAAGAAGGAAAATATCTGCCTACCGATCCCCAGCAGGTGAAATTTTTAAAAGATTATGCGCTCAAAC
CTACACGAATTTATGTATCTAGTATATTAAAACTTTTGCAACAGGTTTCCGTTAAAGGGATGGTTCATATTACAGGGGGA
GGGTATCAGGAGAATATACCTAGAATTCTTCCACAAGGAACTCAGTCGAAATTTTTTAAAGAAAAGATTCCTTCCGGATA
TTTTTTCGAAAAAATTAAAAAAGATCATAAAATAGAAGAGTTAGAATTATTTGCTACTTTTAATATGGGAATCGGATATA
TGGTGATCGTTTCCGAAGAGAACGCAGAACTTGCAAAAAAAATCATGGAAAGTTCTGGCGAAGTCGTTCACGAAATAGGA
GAGATCGTATCCGGAAATAAGGAAGAAGTCCAGTTCGTCTAA

Upstream 100 bases:

>100_bases
TTTTTTTTGTGTGCAGGGAATATCGATTTTTTCAATCTATTCTAAAAAAGAATCGGGACTTATAGGAATGGAAGAAAAGA
TTACATATAAAAACGCCGGA

Downstream 100 bases:

>100_bases
TGTTACTTTTATGAATAGGATTTCCGAGTTGCTTCGATCCCCCGTACTTATACTTTCCAGAAAGAACCCTTTTATGCTTT
CTAGACTTACGTTTTTTTAC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MDTEKGREFIQKIKRNVESTHGPRVIGGLGGFAGAYDVSVLKKYKHPILLSGTDGVGTKIELARLLKIYNTIGIDLVAMC
VNDILVCGGEPFFFLDYIACGKLDPEKMDQIVSGIVQGCKMSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSMID
GSTIRSGDKILGLESSGPHSNGFSLIRKLLLKEGKYLPTDPQQVKFLKDYALKPTRIYVSSILKLLQQVSVKGMVHITGG
GYQENIPRILPQGTQSKFFKEKIPSGYFFEKIKKDHKIEELELFATFNMGIGYMVIVSEENAELAKKIMESSGEVVHEIG
EIVSGNKEEVQFV

Sequences:

>Translated_333_residues
MDTEKGREFIQKIKRNVESTHGPRVIGGLGGFAGAYDVSVLKKYKHPILLSGTDGVGTKIELARLLKIYNTIGIDLVAMC
VNDILVCGGEPFFFLDYIACGKLDPEKMDQIVSGIVQGCKMSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSMID
GSTIRSGDKILGLESSGPHSNGFSLIRKLLLKEGKYLPTDPQQVKFLKDYALKPTRIYVSSILKLLQQVSVKGMVHITGG
GYQENIPRILPQGTQSKFFKEKIPSGYFFEKIKKDHKIEELELFATFNMGIGYMVIVSEENAELAKKIMESSGEVVHEIG
EIVSGNKEEVQFV
>Mature_333_residues
MDTEKGREFIQKIKRNVESTHGPRVIGGLGGFAGAYDVSVLKKYKHPILLSGTDGVGTKIELARLLKIYNTIGIDLVAMC
VNDILVCGGEPFFFLDYIACGKLDPEKMDQIVSGIVQGCKMSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSMID
GSTIRSGDKILGLESSGPHSNGFSLIRKLLLKEGKYLPTDPQQVKFLKDYALKPTRIYVSSILKLLQQVSVKGMVHITGG
GYQENIPRILPQGTQSKFFKEKIPSGYFFEKIKKDHKIEELELFATFNMGIGYMVIVSEENAELAKKIMESSGEVVHEIG
EIVSGNKEEVQFV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=330, Percent_Identity=42.7272727272727, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI209869995, Length=330, Percent_Identity=42.7272727272727, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI209869993, Length=330, Percent_Identity=42.7272727272727, Blast_Score=249, Evalue=2e-66,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=45.045045045045, Blast_Score=297, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=38.3040935672515, Blast_Score=207, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6321203, Length=326, Percent_Identity=39.2638036809816, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24582400, Length=275, Percent_Identity=37.8181818181818, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36576; Mature: 36576

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTEKGREFIQKIKRNVESTHGPRVIGGLGGFAGAYDVSVLKKYKHPILLSGTDGVGTKI
CCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHH
ELARLLKIYNTIGIDLVAMCVNDILVCGGEPFFFLDYIACGKLDPEKMDQIVSGIVQGCK
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
MSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSMIDGSTIRSGDKILGLESSGPHS
CCCCCEECCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCCCCC
NGFSLIRKLLLKEGKYLPTDPQQVKFLKDYALKPTRIYVSSILKLLQQVSVKGMVHITGG
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECC
GYQENIPRILPQGTQSKFFKEKIPSGYFFEKIKKDHKIEELELFATFNMGIGYMVIVSEE
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHEEEEECCCCEEEEEEECC
NAELAKKIMESSGEVVHEIGEIVSGNKEEVQFV
CHHHHHHHHHCCCHHHHHHHHHHCCCHHHEECC
>Mature Secondary Structure
MDTEKGREFIQKIKRNVESTHGPRVIGGLGGFAGAYDVSVLKKYKHPILLSGTDGVGTKI
CCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHH
ELARLLKIYNTIGIDLVAMCVNDILVCGGEPFFFLDYIACGKLDPEKMDQIVSGIVQGCK
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
MSNASLLGGETAEHPGTMKEDEFDLAGFVVGAVEKDSMIDGSTIRSGDKILGLESSGPHS
CCCCCEECCCCCCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCEEEEECCCCCCC
NGFSLIRKLLLKEGKYLPTDPQQVKFLKDYALKPTRIYVSSILKLLQQVSVKGMVHITGG
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECC
GYQENIPRILPQGTQSKFFKEKIPSGYFFEKIKKDHKIEELELFATFNMGIGYMVIVSEE
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCHHHHHEEEEECCCCEEEEEEECC
NAELAKKIMESSGEVVHEIGEIVSGNKEEVQFV
CHHHHHHHHHCCCHHHHHHHHHHCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA