| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is dxs
Identifier: 45656754
GI number: 45656754
Start: 1040546
End: 1042450
Strand: Direct
Name: dxs
Synonym: LIC10863
Alternate gene names: 45656754
Gene position: 1040546-1042450 (Clockwise)
Preceding gene: 45656753
Following gene: 45656755
Centisome position: 24.33
GC content: 39.79
Gene sequence:
>1905_bases ATGCAACAGGAACTAACTCTGCTCGATAGAATCAACTATCCAGCTGAACTAAGAAATATACCACTGGAAAAGCTGCCTCA AATTTGTAAGGAGGTTAGAAATTACATCATCGATACACTTTCGGGGATTGGTGGACATTTTGCAAGTAATCTGGGAGTCG TAGAACTCACGGTCGCCTTACACTATGTATTCGATACTCCAAAAGATCGATTGGTTTGGGACGTAGGGCATCAGACTTAC CCGCATAAGATACTTACGGGAAGAAAGGACAAACTCAATACTGTGCGAAAGTTCAATGGACTTTCCGGGTTTCCTAAAAG AGAAGAATCTCCATACGATTTATATAATACCGGACACGCGGGAACTTCAATATCCCAGGCACTGGGGGAAGCCGCGGCTC GGGATCTAGTAAAAGAAAATTATAATGTAGTCGCTATCATAGGAGACGCGTCGATTGCTACGGGAATGGCTCTTGAAGCG ATGAATCACGCGGGGCATTTGAAAAAGGACATGATCGTAATCTTGAATGATAATTACATGTCTATATCCAAAAATGTAGG ATCTATATCTAATTATCTTAACAACATCATTACATCTCATTTTTACAATCATTGGAAGAGAGTATTTTATACTTTCTTAA AGTGGTTACCGATCATTGGACCTGCAACCGAAAGATTTTTTAAAAAAGTAGAAAAAGGATTTAAGGACGTATTAACTCCG GGTGGGTTATTTGAGGATTTGGGATTTGGGTATATAGGGCCTGAAGATGGGCATGACGTGATACGGCTCGTAAAGATGCT TGAAAAAGTCAAAAAAATGAAGGGTCCAATCTTATTGCATATTATTACACAAAAAGGAAAAGGTTACGATCCGGCGGAGA GGGATCCAATTAAGTATCACGGAGTAACACCGTTTCGAAAAGAAGACGGAGCGATGGATAGTGGGGATACATCTAAAATT GCATATAGTAAAATTGTAGGAAAGATGTTGGCCATTTTAACGGAAACAAATCCTAAAATTGCGGCAATCACTCCTGCGAT GATAGAAGGAAGCGGGCTTAAAGAATACGCAGAAAAATATCCGGAACATTTATTTGATGTGGGAATTGCGGAACAACATT CGGTAGCATTTGCAGGAGCAATGACGAATGGAAACATCATACCATATATGTGTATCTATTCTACTTTTTTGACAAGGGCG ATGGATCAACTTGTACAAGACGTATCTCTCATGAATCTACCGGTGCGGTTTGTGATAGATCGAGCTGGATGTGTGGGGCC GGATGGAGAAACTCACCAAGGACTTTTTGATTTAGGATATTTATTAGGACTTCCTAATATGGACGTATTTGTACCGTCTA ATGGACAGGATTTGATAGATGCGTTACGATGGATGGAAAAATACGATAAGTCGCCGGTTGCAATTCGATTTCCAAAATCG AGTGTGGATTTAAAGACTTTAGATTTTTATAAAGAGACGGAGTTACAACCTGGAACGTTTAGAGTATTTAAAAGAGGAAC GGATGTAGCACTCATATCGATCGGTTCCATGATTGACGAAGCTAAAAAAGCTTCTGAAAGATTAGAGAACGAAGGGTTGA GTGTAACTCTAATTGATTTGGTATGGCTGCGACCACTTGGTGCAGAAGCGCTTAACGAAGAATTGGTGAACGTTAGGTGT TTTGTGATATTAGACGAAAGTTATATAGACTCAGGAGTAACTGGATATTTACTCAACCGAATGACACGGGAGAATTTATC AAAATATATAAAAACATTTGGATTTCCACCGGAGCCGATCCATCACGGAGAAAGGAAGGAAGTTTTCCAAAAGTATAGAT TAGACGGTGAATCGATTGCGGAACAAGTCGCTGCGGTATTGAAAAAAAACTTAATCAAGCCTTAA
Upstream 100 bases:
>100_bases ATGAGTTATTGGATTTAGTGAACGAAGAAGACCTAAAACTATTGAGAAAACCTTTGCAGGCGAACTGAGGGATGGAATAA AATTATATTAGAAAGTTTTC
Downstream 100 bases:
>100_bases CCAATCCAAACCGAAAATAAAATAAAACGGGTAATGGAATTGGACAACTATACTTCTTCGGATTTTTTAGAAGCGGCAAA ATACTTTTACAAAAAAGGTG
Product: 1-deoxy-D-xylulose-5-phosphate synthase
Products: NA
Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]
Number of amino acids: Translated: 634; Mature: 634
Protein sequence:
>634_residues MQQELTLLDRINYPAELRNIPLEKLPQICKEVRNYIIDTLSGIGGHFASNLGVVELTVALHYVFDTPKDRLVWDVGHQTY PHKILTGRKDKLNTVRKFNGLSGFPKREESPYDLYNTGHAGTSISQALGEAAARDLVKENYNVVAIIGDASIATGMALEA MNHAGHLKKDMIVILNDNYMSISKNVGSISNYLNNIITSHFYNHWKRVFYTFLKWLPIIGPATERFFKKVEKGFKDVLTP GGLFEDLGFGYIGPEDGHDVIRLVKMLEKVKKMKGPILLHIITQKGKGYDPAERDPIKYHGVTPFRKEDGAMDSGDTSKI AYSKIVGKMLAILTETNPKIAAITPAMIEGSGLKEYAEKYPEHLFDVGIAEQHSVAFAGAMTNGNIIPYMCIYSTFLTRA MDQLVQDVSLMNLPVRFVIDRAGCVGPDGETHQGLFDLGYLLGLPNMDVFVPSNGQDLIDALRWMEKYDKSPVAIRFPKS SVDLKTLDFYKETELQPGTFRVFKRGTDVALISIGSMIDEAKKASERLENEGLSVTLIDLVWLRPLGAEALNEELVNVRC FVILDESYIDSGVTGYLLNRMTRENLSKYIKTFGFPPEPIHHGERKEVFQKYRLDGESIAEQVAAVLKKNLIKP
Sequences:
>Translated_634_residues MQQELTLLDRINYPAELRNIPLEKLPQICKEVRNYIIDTLSGIGGHFASNLGVVELTVALHYVFDTPKDRLVWDVGHQTY PHKILTGRKDKLNTVRKFNGLSGFPKREESPYDLYNTGHAGTSISQALGEAAARDLVKENYNVVAIIGDASIATGMALEA MNHAGHLKKDMIVILNDNYMSISKNVGSISNYLNNIITSHFYNHWKRVFYTFLKWLPIIGPATERFFKKVEKGFKDVLTP GGLFEDLGFGYIGPEDGHDVIRLVKMLEKVKKMKGPILLHIITQKGKGYDPAERDPIKYHGVTPFRKEDGAMDSGDTSKI AYSKIVGKMLAILTETNPKIAAITPAMIEGSGLKEYAEKYPEHLFDVGIAEQHSVAFAGAMTNGNIIPYMCIYSTFLTRA MDQLVQDVSLMNLPVRFVIDRAGCVGPDGETHQGLFDLGYLLGLPNMDVFVPSNGQDLIDALRWMEKYDKSPVAIRFPKS SVDLKTLDFYKETELQPGTFRVFKRGTDVALISIGSMIDEAKKASERLENEGLSVTLIDLVWLRPLGAEALNEELVNVRC FVILDESYIDSGVTGYLLNRMTRENLSKYIKTFGFPPEPIHHGERKEVFQKYRLDGESIAEQVAAVLKKNLIKP >Mature_634_residues MQQELTLLDRINYPAELRNIPLEKLPQICKEVRNYIIDTLSGIGGHFASNLGVVELTVALHYVFDTPKDRLVWDVGHQTY PHKILTGRKDKLNTVRKFNGLSGFPKREESPYDLYNTGHAGTSISQALGEAAARDLVKENYNVVAIIGDASIATGMALEA MNHAGHLKKDMIVILNDNYMSISKNVGSISNYLNNIITSHFYNHWKRVFYTFLKWLPIIGPATERFFKKVEKGFKDVLTP GGLFEDLGFGYIGPEDGHDVIRLVKMLEKVKKMKGPILLHIITQKGKGYDPAERDPIKYHGVTPFRKEDGAMDSGDTSKI AYSKIVGKMLAILTETNPKIAAITPAMIEGSGLKEYAEKYPEHLFDVGIAEQHSVAFAGAMTNGNIIPYMCIYSTFLTRA MDQLVQDVSLMNLPVRFVIDRAGCVGPDGETHQGLFDLGYLLGLPNMDVFVPSNGQDLIDALRWMEKYDKSPVAIRFPKS SVDLKTLDFYKETELQPGTFRVFKRGTDVALISIGSMIDEAKKASERLENEGLSVTLIDLVWLRPLGAEALNEELVNVRC FVILDESYIDSGVTGYLLNRMTRENLSKYIKTFGFPPEPIHHGERKEVFQKYRLDGESIAEQVAAVLKKNLIKP
Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]
COG id: COG1154
COG function: function code HI; Deoxyxylulose-5-phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transketolase family. DXPS subfamily [H]
Homologues:
Organism=Homo sapiens, GI205277463, Length=637, Percent_Identity=21.8210361067504, Blast_Score=87, Evalue=5e-17, Organism=Homo sapiens, GI4507521, Length=637, Percent_Identity=21.8210361067504, Blast_Score=87, Evalue=5e-17, Organism=Homo sapiens, GI133778974, Length=590, Percent_Identity=22.7118644067797, Blast_Score=72, Evalue=2e-12, Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=42.0545746388443, Blast_Score=503, Evalue=1e-143, Organism=Caenorhabditis elegans, GI17539652, Length=599, Percent_Identity=23.3722871452421, Blast_Score=92, Evalue=7e-19, Organism=Drosophila melanogaster, GI24666278, Length=561, Percent_Identity=22.8163992869875, Blast_Score=94, Evalue=2e-19, Organism=Drosophila melanogaster, GI45551847, Length=603, Percent_Identity=23.0514096185738, Blast_Score=88, Evalue=2e-17, Organism=Drosophila melanogaster, GI45550715, Length=603, Percent_Identity=23.0514096185738, Blast_Score=88, Evalue=2e-17, Organism=Drosophila melanogaster, GI24645119, Length=560, Percent_Identity=23.3928571428571, Blast_Score=88, Evalue=2e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005477 - InterPro: IPR009014 - InterPro: IPR015941 - InterPro: IPR005475 - InterPro: IPR005476 - InterPro: IPR005474 [H]
Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]
EC number: =2.2.1.7 [H]
Molecular weight: Translated: 71032; Mature: 71032
Theoretical pI: Translated: 7.00; Mature: 7.00
Prosite motif: PS00801 TRANSKETOLASE_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQQELTLLDRINYPAELRNIPLEKLPQICKEVRNYIIDTLSGIGGHFASNLGVVELTVAL CCCHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH HYVFDTPKDRLVWDVGHQTYPHKILTGRKDKLNTVRKFNGLSGFPKREESPYDLYNTGHA HHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC GTSISQALGEAAARDLVKENYNVVAIIGDASIATGMALEAMNHAGHLKKDMIVILNDNYM CCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCE SISKNVGSISNYLNNIITSHFYNHWKRVFYTFLKWLPIIGPATERFFKKVEKGFKDVLTP EHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC GGLFEDLGFGYIGPEDGHDVIRLVKMLEKVKKMKGPILLHIITQKGKGYDPAERDPIKYH CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEC GVTPFRKEDGAMDSGDTSKIAYSKIVGKMLAILTETNPKIAAITPAMIEGSGLKEYAEKY CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCHHHHHHHH PEHLFDVGIAEQHSVAFAGAMTNGNIIPYMCIYSTFLTRAMDQLVQDVSLMNLPVRFVID HHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEE RAGCVGPDGETHQGLFDLGYLLGLPNMDVFVPSNGQDLIDALRWMEKYDKSPVAIRFPKS CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCC SVDLKTLDFYKETELQPGTFRVFKRGTDVALISIGSMIDEAKKASERLENEGLSVTLIDL CCCCHHHHHHHHCCCCCCHHHEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEHH VWLRPLGAEALNEELVNVRCFVILDESYIDSGVTGYLLNRMTRENLSKYIKTFGFPPEPI HHHCCCCHHHHHHHHHCEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC HHGERKEVFQKYRLDGESIAEQVAAVLKKNLIKP CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure MQQELTLLDRINYPAELRNIPLEKLPQICKEVRNYIIDTLSGIGGHFASNLGVVELTVAL CCCHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH HYVFDTPKDRLVWDVGHQTYPHKILTGRKDKLNTVRKFNGLSGFPKREESPYDLYNTGHA HHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC GTSISQALGEAAARDLVKENYNVVAIIGDASIATGMALEAMNHAGHLKKDMIVILNDNYM CCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCE SISKNVGSISNYLNNIITSHFYNHWKRVFYTFLKWLPIIGPATERFFKKVEKGFKDVLTP EHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC GGLFEDLGFGYIGPEDGHDVIRLVKMLEKVKKMKGPILLHIITQKGKGYDPAERDPIKYH CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEC GVTPFRKEDGAMDSGDTSKIAYSKIVGKMLAILTETNPKIAAITPAMIEGSGLKEYAEKY CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCHHHHHHHH PEHLFDVGIAEQHSVAFAGAMTNGNIIPYMCIYSTFLTRAMDQLVQDVSLMNLPVRFVID HHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEE RAGCVGPDGETHQGLFDLGYLLGLPNMDVFVPSNGQDLIDALRWMEKYDKSPVAIRFPKS CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCC SVDLKTLDFYKETELQPGTFRVFKRGTDVALISIGSMIDEAKKASERLENEGLSVTLIDL CCCCHHHHHHHHCCCCCCHHHEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEHH VWLRPLGAEALNEELVNVRCFVILDESYIDSGVTGYLLNRMTRENLSKYIKTFGFPPEPI HHHCCCCHHHHHHHHHCEEEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC HHGERKEVFQKYRLDGESIAEQVAAVLKKNLIKP CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA