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The map label for this gene is lpxK

Identifier: 45656429

GI number: 45656429

Start: 643645

End: 644688

Strand: Reverse

Name: lpxK

Synonym: LIC10531

Alternate gene names: 45656429

Gene position: 644688-643645 (Counterclockwise)

Preceding gene: 45656430

Following gene: 45656428

Centisome position: 15.07

GC content: 31.61

Gene sequence:

>1044_bases
ATGAACTCTTTTTCTATTCTATCTATATTACAAATTATACTGTTTCCAATTTTATATGTTTTTTCCTTTTTGTATCGAGC
TCTTTTTTTACTCGATCAGAAACTTACAAAAAAGAAAAAACTTCCGGGCGCTTTTGTAATCAGCGTAGGAAATCTTTCCA
TGGGAGGAACCGGAAAAACTCCGTTTTCCATCTTTCTTGCAAAACTAATTCATAAAAAATTTCCAGATCAGAAAATCATC
ATCTTATCCCGAGGTTATAGTGCCAAAGGTTCTCTACGAGGACATCGTGTAGGTCCACACTCAACCCCAATGGAAGCAGG
AGACGAACCTCTTCTATTAAAAAAACATCTTCCATTTGCCGAGGTTTGGATTGGAAAAGACAGATACTCTTCTTATATTC
ATTTTAGAGAAGAGTTAAGGATGCGAGAAAATTCAATCGTAATTTTAGACGACGGTTTTCAACATCACGTTTTAGAAAGA
GATGTTGATCTTGTTTTATTAGACTCAAGTAAAATTTCTAAAGAACGTTTTTTAATTCCTGCGGGAAATTTGAGAGAGCC
TATCTCTTCTTTAATAAGAGCTGATCAGATCATATTTTCTAAATATGAGTCTTCCATTGAAAAAATTGTTCAAAATATTC
AAAATAAATTTTCTAAAGAAATCCTTCGTTTTTCTTTGGAACCGGATAAACTTTTATCTCCTAATCTACAATCCGATTCT
CCTAAAATATTATCCGGTAAAAAAGTATACGCATTTACTGGAATCGGAAATCCGGAAGTTTTTTTTTCGATGATCCGTAA
GTTTGAACCGTTAAAGTTGGAAACAAGAGCTTTTAGAGATCACCATTCTTATACTATAGAAGACGAAAACGTTTTGAATT
TGATCGCTAAAAATTTCGACTTCCTAGTCTGTACTGAAAAAGATCTAGTTAAAATTTCTAATCCTCCAAATCAATTAAGA
ATTCTTCTTTTAAAAAGTAAGTTAGATAAAGAAGAATTCTTAATTTCTTTTCTACAAAAAAAAATCTCTTTAAAAACATT
CTAA

Upstream 100 bases:

>100_bases
GAACTCATACGGAATTACTTCAACTGGACGGAAAATATAAAAAACTTTACGACATACAATTTTCGGAAAACGTATAATTT
AAAAGAATCTTAATATTCTT

Downstream 100 bases:

>100_bases
TCTTTCAACTCTATTCATAAATGATAATAATTAGAAAAATATTTTGAGCAGATTCTAAAAATGAAATCTACAAAACTGTT
TTTTCTTTCTCTGAAAAGAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNSFSILSILQIILFPILYVFSFLYRALFLLDQKLTKKKKLPGAFVISVGNLSMGGTGKTPFSIFLAKLIHKKFPDQKII
ILSRGYSAKGSLRGHRVGPHSTPMEAGDEPLLLKKHLPFAEVWIGKDRYSSYIHFREELRMRENSIVILDDGFQHHVLER
DVDLVLLDSSKISKERFLIPAGNLREPISSLIRADQIIFSKYESSIEKIVQNIQNKFSKEILRFSLEPDKLLSPNLQSDS
PKILSGKKVYAFTGIGNPEVFFSMIRKFEPLKLETRAFRDHHSYTIEDENVLNLIAKNFDFLVCTEKDLVKISNPPNQLR
ILLLKSKLDKEEFLISFLQKKISLKTF

Sequences:

>Translated_347_residues
MNSFSILSILQIILFPILYVFSFLYRALFLLDQKLTKKKKLPGAFVISVGNLSMGGTGKTPFSIFLAKLIHKKFPDQKII
ILSRGYSAKGSLRGHRVGPHSTPMEAGDEPLLLKKHLPFAEVWIGKDRYSSYIHFREELRMRENSIVILDDGFQHHVLER
DVDLVLLDSSKISKERFLIPAGNLREPISSLIRADQIIFSKYESSIEKIVQNIQNKFSKEILRFSLEPDKLLSPNLQSDS
PKILSGKKVYAFTGIGNPEVFFSMIRKFEPLKLETRAFRDHHSYTIEDENVLNLIAKNFDFLVCTEKDLVKISNPPNQLR
ILLLKSKLDKEEFLISFLQKKISLKTF
>Mature_347_residues
MNSFSILSILQIILFPILYVFSFLYRALFLLDQKLTKKKKLPGAFVISVGNLSMGGTGKTPFSIFLAKLIHKKFPDQKII
ILSRGYSAKGSLRGHRVGPHSTPMEAGDEPLLLKKHLPFAEVWIGKDRYSSYIHFREELRMRENSIVILDDGFQHHVLER
DVDLVLLDSSKISKERFLIPAGNLREPISSLIRADQIIFSKYESSIEKIVQNIQNKFSKEILRFSLEPDKLLSPNLQSDS
PKILSGKKVYAFTGIGNPEVFFSMIRKFEPLKLETRAFRDHHSYTIEDENVLNLIAKNFDFLVCTEKDLVKISNPPNQLR
ILLLKSKLDKEEFLISFLQKKISLKTF

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=313, Percent_Identity=27.4760383386581, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 39886; Mature: 39886

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSFSILSILQIILFPILYVFSFLYRALFLLDQKLTKKKKLPGAFVISVGNLSMGGTGKT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
PFSIFLAKLIHKKFPDQKIIILSRGYSAKGSLRGHRVGPHSTPMEAGDEPLLLKKHLPFA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHH
EVWIGKDRYSSYIHFREELRMRENSIVILDDGFQHHVLERDVDLVLLDSSKISKERFLIP
HHEECHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEECCCCCCCCEEEEC
AGNLREPISSLIRADQIIFSKYESSIEKIVQNIQNKFSKEILRFSLEPDKLLSPNLQSDS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCC
PKILSGKKVYAFTGIGNPEVFFSMIRKFEPLKLETRAFRDHHSYTIEDENVLNLIAKNFD
CCEECCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEECCHHHHHHHHCCCC
FLVCTEKDLVKISNPPNQLRILLLKSKLDKEEFLISFLQKKISLKTF
EEEECCCCCEEECCCHHHEEEEEEHHHCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSFSILSILQIILFPILYVFSFLYRALFLLDQKLTKKKKLPGAFVISVGNLSMGGTGKT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
PFSIFLAKLIHKKFPDQKIIILSRGYSAKGSLRGHRVGPHSTPMEAGDEPLLLKKHLPFA
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHH
EVWIGKDRYSSYIHFREELRMRENSIVILDDGFQHHVLERDVDLVLLDSSKISKERFLIP
HHEECHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEECCCCCCCCEEEEC
AGNLREPISSLIRADQIIFSKYESSIEKIVQNIQNKFSKEILRFSLEPDKLLSPNLQSDS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCC
PKILSGKKVYAFTGIGNPEVFFSMIRKFEPLKLETRAFRDHHSYTIEDENVLNLIAKNFD
CCEECCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHCCCCEEECCHHHHHHHHCCCC
FLVCTEKDLVKISNPPNQLRILLLKSKLDKEEFLISFLQKKISLKTF
EEEECCCCCEEECCCHHHEEEEEEHHHCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA