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The map label for this gene is mccB

Identifier: 45656342

GI number: 45656342

Start: 505348

End: 506958

Strand: Reverse

Name: mccB

Synonym: LIC10443

Alternate gene names: 45656342

Gene position: 506958-505348 (Counterclockwise)

Preceding gene: 45656343

Following gene: 45656341

Centisome position: 11.85

GC content: 40.53

Gene sequence:

>1611_bases
GTGGAAATCATAGAATCCAAAATACGTACGTCTTCATCAGAGTATAAAGAAAATTTCGAAGATCTCAAACAAAAGGTGGA
ATCCTTACGAAATCTGATTCGTAAAATTGAATTAGGTGGCGGTGAAAAAGCGATCGAGCGTCACAAAGGAAGAGGTAAAC
TCACAGCAAGAGAAAGAGTTTCCTCTCTCATCGATCCTGGGACTTCTTTTCTAGAATTCTCACCTCTGGCTGCGGAAGGA
GTTTATTCAGACTCAGTTCCTTCCGCCGGAATTCTAACAGGAATTGGAAGAATCTGCGGAGTTGATTGTGTGATCGTTGC
AAACGACGCTACTGTTAAAGGAGGAACGTATTATCCTCTTACGGTAAAAAAACATATCCGCGCACAAGAGATCGCTCTTC
AAAATTTCCTTCCTTGTATTTATCTTGTGGATTCAGGAGGAGCCTTTCTTCCGATGCAAGACGAAGTGTTTCCAGATAAA
GATCATTTCGGAAAAATCTTTTATAACCAAGCCAATCTTTCCGCGTTAAAGATCCCTCAGATCTCAGTAGTTATGGGAAG
CTGCACTGCGGGCGGAGCTTATATTCCTGCAATGTCAGACGAATCCGTAATTGTCAAAGGAAACGGTACGATTTTTTTAG
GCGGTCCTCCTCTTGTAAAAGCGGCAACGGGAGAAATTGTAACTCCGGAAGAATTGGGTGGAGCCTTAGTTCACAGCACG
ATTTCAGGTGTAACTGATCATTACGCGGAAGACGACTCACACGCTCTTGAAATCACAAGAAACATAGTATCTACATTCCA
TCACGCGGGGAACGTAACACAACGGGGATCGATCAATTGGGAAGAACCTTTATATCCTGCGGAAGAAATTTACGGAATCA
TACAAAAAGACATTCGTAAGTCTTATGACGTACGAGAAATCATTGCAAGAATCGTAGACGGTTCCAGGTTTCAAGAATTC
AAAAAGTATTATGGAACCACTCTCGTAACAGGTTTTGCAAAAATTTATGGAAAGATGGTGGGGATCATAGCAAACAACGG
AGTTTTGTTTTCGGAAAGTGCGCTTAAGGCTTCTCATTTTATTGAACTTTGTAATCAGAGAGAGATTCCTCTTTTGTTCC
TTCAAAACATTACCGGTTTTATGGTAGGTAAAAAATATGAAAATTCTGGAATCGCAAAAGATGGGGCAAAGATGGTGAAT
GCGGTTTCTACTTCCATTGTGCCTAAGTATTCTGTAGTGATCGGAGGTTCTTACGGCGCTGGAAACTACGGAATGTGTGG
AAGAGCTTTTAATCCTAGATTCTTATGGATGTGGCCTAATTCCAGAATCTCCGTAATGGGTGGTGAACAAGCGGCTAACG
TTCTTTTGACGGTAAAGATGGAACAATTAGAAAAAGAAGGAAAAAAATTATCTGAGGCAGAACAGTTTGCATTTCGTAAA
CCGATCTTGGATGATTATGAAAGTAAATCTTCTTGTATTTATTCATCTGCAAGACTTTGGGATGATGGAGTGATCGATCC
AGCCAGAACAAGGGATATTTTAGGAATTACTGTCTACGCAAATCATTCTCAAAAGTTAGAATATCCTCGGTACGGAATTT
TTAGAATGTAA

Upstream 100 bases:

>100_bases
ATCATGGCGAGAAGGAACCGAGAGTTAACGTTATCCGAAACTGAATTGATCCGTATATTATACGAATCTAAAGTAAAAAA
ATAAAAATCCGGAGGGTTTT

Downstream 100 bases:

>100_bases
AAAATTGTAAGAACCCACCTTCTCTTGATTTGTAATTTTAATTTATCAACCAATCTTTTAGGTGTTTATTTTTTTATCCC
GATTTACAAATTTAAAAATT

Product: 3-methylcrotonoyl-CoA carboxylase subunit beta

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MEIIESKIRTSSSEYKENFEDLKQKVESLRNLIRKIELGGGEKAIERHKGRGKLTARERVSSLIDPGTSFLEFSPLAAEG
VYSDSVPSAGILTGIGRICGVDCVIVANDATVKGGTYYPLTVKKHIRAQEIALQNFLPCIYLVDSGGAFLPMQDEVFPDK
DHFGKIFYNQANLSALKIPQISVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEIVTPEELGGALVHST
ISGVTDHYAEDDSHALEITRNIVSTFHHAGNVTQRGSINWEEPLYPAEEIYGIIQKDIRKSYDVREIIARIVDGSRFQEF
KKYYGTTLVTGFAKIYGKMVGIIANNGVLFSESALKASHFIELCNQREIPLLFLQNITGFMVGKKYENSGIAKDGAKMVN
AVSTSIVPKYSVVIGGSYGAGNYGMCGRAFNPRFLWMWPNSRISVMGGEQAANVLLTVKMEQLEKEGKKLSEAEQFAFRK
PILDDYESKSSCIYSSARLWDDGVIDPARTRDILGITVYANHSQKLEYPRYGIFRM

Sequences:

>Translated_536_residues
MEIIESKIRTSSSEYKENFEDLKQKVESLRNLIRKIELGGGEKAIERHKGRGKLTARERVSSLIDPGTSFLEFSPLAAEG
VYSDSVPSAGILTGIGRICGVDCVIVANDATVKGGTYYPLTVKKHIRAQEIALQNFLPCIYLVDSGGAFLPMQDEVFPDK
DHFGKIFYNQANLSALKIPQISVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEIVTPEELGGALVHST
ISGVTDHYAEDDSHALEITRNIVSTFHHAGNVTQRGSINWEEPLYPAEEIYGIIQKDIRKSYDVREIIARIVDGSRFQEF
KKYYGTTLVTGFAKIYGKMVGIIANNGVLFSESALKASHFIELCNQREIPLLFLQNITGFMVGKKYENSGIAKDGAKMVN
AVSTSIVPKYSVVIGGSYGAGNYGMCGRAFNPRFLWMWPNSRISVMGGEQAANVLLTVKMEQLEKEGKKLSEAEQFAFRK
PILDDYESKSSCIYSSARLWDDGVIDPARTRDILGITVYANHSQKLEYPRYGIFRM
>Mature_536_residues
MEIIESKIRTSSSEYKENFEDLKQKVESLRNLIRKIELGGGEKAIERHKGRGKLTARERVSSLIDPGTSFLEFSPLAAEG
VYSDSVPSAGILTGIGRICGVDCVIVANDATVKGGTYYPLTVKKHIRAQEIALQNFLPCIYLVDSGGAFLPMQDEVFPDK
DHFGKIFYNQANLSALKIPQISVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEIVTPEELGGALVHST
ISGVTDHYAEDDSHALEITRNIVSTFHHAGNVTQRGSINWEEPLYPAEEIYGIIQKDIRKSYDVREIIARIVDGSRFQEF
KKYYGTTLVTGFAKIYGKMVGIIANNGVLFSESALKASHFIELCNQREIPLLFLQNITGFMVGKKYENSGIAKDGAKMVN
AVSTSIVPKYSVVIGGSYGAGNYGMCGRAFNPRFLWMWPNSRISVMGGEQAANVLLTVKMEQLEKEGKKLSEAEQFAFRK
PILDDYESKSSCIYSSARLWDDGVIDPARTRDILGITVYANHSQKLEYPRYGIFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=528, Percent_Identity=61.5530303030303, Blast_Score=667, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=543, Percent_Identity=30.2025782688766, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI295821216, Length=563, Percent_Identity=29.3072824156306, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=57.7777777777778, Blast_Score=145, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17552936, Length=539, Percent_Identity=59.9257884972171, Blast_Score=672, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=519, Percent_Identity=29.4797687861272, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147359, Length=519, Percent_Identity=29.4797687861272, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=60.9090909090909, Blast_Score=701, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 58946; Mature: 58946

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIESKIRTSSSEYKENFEDLKQKVESLRNLIRKIELGGGEKAIERHKGRGKLTARERV
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHH
SSLIDPGTSFLEFSPLAAEGVYSDSVPSAGILTGIGRICGVDCVIVANDATVKGGTYYPL
HHHHCCCCCCEECCCCHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCEECCCEEEEE
TVKKHIRAQEIALQNFLPCIYLVDSGGAFLPMQDEVFPDKDHFGKIFYNQANLSALKIPQ
EHHHHHHHHHHHHHHCCCEEEEEECCCEECCCCCCCCCCCCCCCEEEEECCCCCEEECCE
ISVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEIVTPEELGGALVHST
EEEEEECCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEECHHHHCCHHHHHH
ISGVTDHYAEDDSHALEITRNIVSTFHHAGNVTQRGSINWEEPLYPAEEIYGIIQKDIRK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
SYDVREIIARIVDGSRFQEFKKYYGTTLVTGFAKIYGKMVGIIANNGVLFSESALKASHF
CCCHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHEEEEECCCEEEEHHHHHHHHH
IELCNQREIPLLFLQNITGFMVGKKYENSGIAKDGAKMVNAVSTSIVPKYSVVIGGSYGA
HHHHCCCCCCEEEECCCHHHEECCEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
GNYGMCGRAFNPRFLWMWPNSRISVMGGEQAANVLLTVKMEQLEKEGKKLSEAEQFAFRK
CCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHC
PILDDYESKSSCIYSSARLWDDGVIDPARTRDILGITVYANHSQKLEYPRYGIFRM
CCHHCCCCCCHHEEHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIIESKIRTSSSEYKENFEDLKQKVESLRNLIRKIELGGGEKAIERHKGRGKLTARERV
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHH
SSLIDPGTSFLEFSPLAAEGVYSDSVPSAGILTGIGRICGVDCVIVANDATVKGGTYYPL
HHHHCCCCCCEECCCCHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCEECCCEEEEE
TVKKHIRAQEIALQNFLPCIYLVDSGGAFLPMQDEVFPDKDHFGKIFYNQANLSALKIPQ
EHHHHHHHHHHHHHHCCCEEEEEECCCEECCCCCCCCCCCCCCCEEEEECCCCCEEECCE
ISVVMGSCTAGGAYIPAMSDESVIVKGNGTIFLGGPPLVKAATGEIVTPEELGGALVHST
EEEEEECCCCCCEEEECCCCCEEEEECCCEEEECCCCEEEECCCCEECHHHHCCHHHHHH
ISGVTDHYAEDDSHALEITRNIVSTFHHAGNVTQRGSINWEEPLYPAEEIYGIIQKDIRK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
SYDVREIIARIVDGSRFQEFKKYYGTTLVTGFAKIYGKMVGIIANNGVLFSESALKASHF
CCCHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHEEEEECCCEEEEHHHHHHHHH
IELCNQREIPLLFLQNITGFMVGKKYENSGIAKDGAKMVNAVSTSIVPKYSVVIGGSYGA
HHHHCCCCCCEEEECCCHHHEECCEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
GNYGMCGRAFNPRFLWMWPNSRISVMGGEQAANVLLTVKMEQLEKEGKKLSEAEQFAFRK
CCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHC
PILDDYESKSSCIYSSARLWDDGVIDPARTRDILGITVYANHSQKLEYPRYGIFRM
CCHHCCCCCCHHEEHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]