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The map label for this gene is secY [H]

Identifier: 45358985

GI number: 45358985

Start: 1393242

End: 1394570

Strand: Direct

Name: secY [H]

Synonym: MMP1422

Alternate gene names: 45358985

Gene position: 1393242-1394570 (Clockwise)

Preceding gene: 45358984

Following gene: 45358987

Centisome position: 83.87

GC content: 37.77

Gene sequence:

>1329_bases
TTGGAAAGTTTTCTATTAAAAATAAAACCTATACTTGAATTAATACCTGAAGTAAAAAGACCACTAAGAGAAATTTCATT
TAAAGAAAAATTACAATGGACTGCACTTGTGCTTGTACTCTACTTTATTTTGGGTACAATCGATATTTACACGGGCGGTT
CAGAAATGCCTGCAATATTTGATTTTTGGCAGACAGTTACTGCTTCAAAAATGGGTACTTTGATTACGCTTGGTATCGGG
CCAATTGTAACTGCAGGAATTATCATGCAGCTCTTGGTCGGGTCCGAACTTATAAGTCTGGATTTATCAAAACCGATGAA
TAGGGCATTATTTCAAGGTTTACAAAAGTTATTTGGTATAGCATTATGTTTCCTCGAAGCTTTGATGTTTGTTGGAGCAG
GGGCATTTGGTGCATTAACCCCACTAATGACGGCAGTGTTAGTATTCCAGCTTGCACTTGGTGCGATATTAATTATTTAT
TTGGATGAAATTGTTTCAAGATACGGTATCGGATCAGGTATCGGTCTTTTCATTGCAGCAGGAGTCTCACAAACAATATT
TGTAGGAACCTTTGGTGCAGAAGGATATTTATGGAAATTCTTCACTGCAATGACTGCAGGAAGTTTATGGACTGCATTAG
AATATATCTTACCAATTTTAGGTACGATACTTGTATTCTTAGTTGTAGTTTACGTTGAAAGTATCAGGGTAGAAATTCCA
CTAGCACACGGAAGAGTAAAAGGTGCTGTTGGAAAATACCCGATAAAATTCATCTATGTTTCAAACCTGCCAGTTATCCT
TGCTGCAGCATTGTTTGCAAACATACAGCTTTGGGGAATGTTTTTAGAAAAAATGGGTTTCCCAATTCTCGGGCACTATA
CGAGTGGTAGGGCAGTTGATGGACTTGCATACTACTTCTCAACACCGTACGGAATTTCAAGTTTGACTGCAGATCCGCTT
CATGCAGTATTTTACACTGTAATGATGGTAATATTCTGTATCTTGTTTGGTCTTTTCTGGGTTGAAACCTCAGGACTTGA
CGCAAAATCGATGGCTAAAAAGCTTGGGAACCTTGATATGGCAATTAAAGGATTTAGAAAAAGCCAAAAATCAATTGAAC
AACGTTTAAAAAGATACATCACACCAATTACAGTAATGGGTTCAGCATTTGTTGGATTTTTAGCCGCAGCTGCTGACTTT
ACAGGGGCCCTTGGTGGAGGTACTGGTGTATTGCTTACAGTATCAATTGTATACAGATTATACGAACAGCTCGTTCAAGA
ACAACTCTCTGAACTTCACCCATCAATTGCGAAGTTCATAAGAAAATAA

Upstream 100 bases:

>100_bases
AATACATTTTCCAAAGATTATCACAATTACACTATTTGATAACAAATTTGTAAATTTTCTCGTTTATTGAAATTTATCAT
GTTTATTCCAAGGTGAAAAT

Downstream 100 bases:

>100_bases
AACTTAAAAAATAATTAGAAATAAAAATTTTTTACTTTTTTAAAAAATATTAAACCCGAAGTATTTTGTATATAAAATAC
TCAAAATTCCAAAAAAGGCT

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MESFLLKIKPILELIPEVKRPLREISFKEKLQWTALVLVLYFILGTIDIYTGGSEMPAIFDFWQTVTASKMGTLITLGIG
PIVTAGIIMQLLVGSELISLDLSKPMNRALFQGLQKLFGIALCFLEALMFVGAGAFGALTPLMTAVLVFQLALGAILIIY
LDEIVSRYGIGSGIGLFIAAGVSQTIFVGTFGAEGYLWKFFTAMTAGSLWTALEYILPILGTILVFLVVVYVESIRVEIP
LAHGRVKGAVGKYPIKFIYVSNLPVILAAALFANIQLWGMFLEKMGFPILGHYTSGRAVDGLAYYFSTPYGISSLTADPL
HAVFYTVMMVIFCILFGLFWVETSGLDAKSMAKKLGNLDMAIKGFRKSQKSIEQRLKRYITPITVMGSAFVGFLAAAADF
TGALGGGTGVLLTVSIVYRLYEQLVQEQLSELHPSIAKFIRK

Sequences:

>Translated_442_residues
MESFLLKIKPILELIPEVKRPLREISFKEKLQWTALVLVLYFILGTIDIYTGGSEMPAIFDFWQTVTASKMGTLITLGIG
PIVTAGIIMQLLVGSELISLDLSKPMNRALFQGLQKLFGIALCFLEALMFVGAGAFGALTPLMTAVLVFQLALGAILIIY
LDEIVSRYGIGSGIGLFIAAGVSQTIFVGTFGAEGYLWKFFTAMTAGSLWTALEYILPILGTILVFLVVVYVESIRVEIP
LAHGRVKGAVGKYPIKFIYVSNLPVILAAALFANIQLWGMFLEKMGFPILGHYTSGRAVDGLAYYFSTPYGISSLTADPL
HAVFYTVMMVIFCILFGLFWVETSGLDAKSMAKKLGNLDMAIKGFRKSQKSIEQRLKRYITPITVMGSAFVGFLAAAADF
TGALGGGTGVLLTVSIVYRLYEQLVQEQLSELHPSIAKFIRK
>Mature_442_residues
MESFLLKIKPILELIPEVKRPLREISFKEKLQWTALVLVLYFILGTIDIYTGGSEMPAIFDFWQTVTASKMGTLITLGIG
PIVTAGIIMQLLVGSELISLDLSKPMNRALFQGLQKLFGIALCFLEALMFVGAGAFGALTPLMTAVLVFQLALGAILIIY
LDEIVSRYGIGSGIGLFIAAGVSQTIFVGTFGAEGYLWKFFTAMTAGSLWTALEYILPILGTILVFLVVVYVESIRVEIP
LAHGRVKGAVGKYPIKFIYVSNLPVILAAALFANIQLWGMFLEKMGFPILGHYTSGRAVDGLAYYFSTPYGISSLTADPL
HAVFYTVMMVIFCILFGLFWVETSGLDAKSMAKKLGNLDMAIKGFRKSQKSIEQRLKRYITPITVMGSAFVGFLAAAADF
TGALGGGTGVLLTVSIVYRLYEQLVQEQLSELHPSIAKFIRK

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI7019415, Length=464, Percent_Identity=35.7758620689655, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI14589847, Length=469, Percent_Identity=34.3283582089552, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI217330618, Length=467, Percent_Identity=32.9764453961456, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI217330616, Length=419, Percent_Identity=32.9355608591885, Blast_Score=209, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17543770, Length=461, Percent_Identity=35.1409978308026, Blast_Score=257, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6323411, Length=457, Percent_Identity=31.9474835886214, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319760, Length=463, Percent_Identity=23.5421166306695, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19920826, Length=469, Percent_Identity=34.7547974413646, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 48295; Mature: 48295

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFLLKIKPILELIPEVKRPLREISFKEKLQWTALVLVLYFILGTIDIYTGGSEMPAIF
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
DFWQTVTASKMGTLITLGIGPIVTAGIIMQLLVGSELISLDLSKPMNRALFQGLQKLFGI
HHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
ALCFLEALMFVGAGAFGALTPLMTAVLVFQLALGAILIIYLDEIVSRYGIGSGIGLFIAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GVSQTIFVGTFGAEGYLWKFFTAMTAGSLWTALEYILPILGTILVFLVVVYVESIRVEIP
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LAHGRVKGAVGKYPIKFIYVSNLPVILAAALFANIQLWGMFLEKMGFPILGHYTSGRAVD
ECCCCHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
GLAYYFSTPYGISSLTADPLHAVFYTVMMVIFCILFGLFWVETSGLDAKSMAKKLGNLDM
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHH
AIKGFRKSQKSIEQRLKRYITPITVMGSAFVGFLAAAADFTGALGGGTGVLLTVSIVYRL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
YEQLVQEQLSELHPSIAKFIRK
HHHHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure
MESFLLKIKPILELIPEVKRPLREISFKEKLQWTALVLVLYFILGTIDIYTGGSEMPAIF
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
DFWQTVTASKMGTLITLGIGPIVTAGIIMQLLVGSELISLDLSKPMNRALFQGLQKLFGI
HHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHH
ALCFLEALMFVGAGAFGALTPLMTAVLVFQLALGAILIIYLDEIVSRYGIGSGIGLFIAA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GVSQTIFVGTFGAEGYLWKFFTAMTAGSLWTALEYILPILGTILVFLVVVYVESIRVEIP
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LAHGRVKGAVGKYPIKFIYVSNLPVILAAALFANIQLWGMFLEKMGFPILGHYTSGRAVD
ECCCCHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
GLAYYFSTPYGISSLTADPLHAVFYTVMMVIFCILFGLFWVETSGLDAKSMAKKLGNLDM
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHH
AIKGFRKSQKSIEQRLKRYITPITVMGSAFVGFLAAAADFTGALGGGTGVLLTVSIVYRL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
YEQLVQEQLSELHPSIAKFIRK
HHHHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1764515 [H]