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The map label for this gene is mre11

Identifier: 45358903

GI number: 45358903

Start: 1319955

End: 1321073

Strand: Direct

Name: mre11

Synonym: MMP1340

Alternate gene names: 45358903

Gene position: 1319955-1321073 (Clockwise)

Preceding gene: 45358901

Following gene: 45358904

Centisome position: 79.46

GC content: 31.19

Gene sequence:

>1119_bases
ATGCAATTTGTTCACATGGCGGATAATCACCTCGGATACCGCCAGTACAACCTTGATGAGCGGGAAAACGATATTTACGA
ATCATTTTTAGAATGTATCGATAAAATTATTGAGATACGCCCTGATTTTGTAATCCATAGTGGCGACTTATTTGAAAGCC
CGCAGCCTCCAGTAAATGCAATAAGATGTGCAATGGAAGGATTATTAAAATTAAAGGAAAAAAATATACCAATTTATTTA
ATCCACGGAAATCACGACATTCCAAAAAGCCAACAGAAAGGAAAACCGTTTGGACTTTTGAAAAAAATACTTGGAAACAG
TTTATTAACGTTTGGAAAAAATAAATCGCATGTTTTTAACAACGAAGTCTTCATTGGAGGAATTGAATACGTATCCCAAA
ACAAAATTCCAAAAACTTACGAGGATTTAGAAAAAATCAATTCTGATTCTAAAAATTATAAAAAAAAGATACTTTTGTTC
CACCAAAGCGTGAACCCATTTATCCCGCAAAGCTTTGAAATGCAAGTTACCGACTTTCCAGACGATTTTAACTACATTGC
AGGAGGCCACATTCATCAAAGAGCATTAAAACCAATCAATGATGGAAATTCAGTATTTTCTTATGCAGGGTCAACTGATA
TCATGTCAGTTAGCGAAGTTAAAGATTACAAAAAAAATGGAAAAGGATTTTATTTGGGCGATTTAAGCGGAGATTTCGAT
ATTAATTCAATTCAAAAGATCGACGTTGAATGTAGAAATTTCTTGATCGATAAAAAAATTAAGAATGAAAATGATTACAA
AAAAACAGTTGAAGAGCTCCAAAATCTTCAAAGTGAAAAGAAAAAGCCAATTTTATACTGTGATATTGTTGAAAATTTAT
TTAATTCGTTTAACGATGAAATTGCCAATTTAACACTTTACAAAAGAATAAGCAGGATTGATGAAAACCTTGAAGAATCT
TTAATCATTAATGAAAGCAGTATTGAAGAGATTTTCCAGGAATATATTAAAAATAAAGAAATGGATGTAAATTTCGTTTA
TGGACTCTATAAAAAGCTTTTAGAGAATGATGAAGATTCACTGCTTTACGTAAATGACTACTTTAAGGGTAATTACTAA

Upstream 100 bases:

>100_bases
TTTTCACATTTTATTTTAAAAAGATTGATGGTACAATAATATAAAAAAATATTTAACGAATACGGTTGAAAGTTAACTTA
AGTAATTTTGGAGCGATATT

Downstream 100 bases:

>100_bases
GGGGGCGCATTTGATGATTATTAAAAATATCAAAATGGAAAACTTCAGAAGCCACAGAAACACATCAATAAATTTTAGCA
AAGGAATAACTTCAATAATC

Product: SbcD/Mre11 family DNA repair exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNAIRCAMEGLLKLKEKNIPIYL
IHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFNNEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLF
HQSVNPFIPQSFEMQVTDFPDDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFD
INSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDEIANLTLYKRISRIDENLEES
LIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDSLLYVNDYFKGNY

Sequences:

>Translated_372_residues
MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNAIRCAMEGLLKLKEKNIPIYL
IHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFNNEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLF
HQSVNPFIPQSFEMQVTDFPDDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFD
INSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDEIANLTLYKRISRIDENLEES
LIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDSLLYVNDYFKGNY
>Mature_372_residues
MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNAIRCAMEGLLKLKEKNIPIYL
IHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFNNEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLF
HQSVNPFIPQSFEMQVTDFPDDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFD
INSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDEIANLTLYKRISRIDENLEES
LIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDSLLYVNDYFKGNY

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRE11_METMP (P62131)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988460.1
- ProteinModelPortal:   P62131
- GeneID:   2761216
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP1340
- NMPDR:   fig|267377.1.peg.1340
- HOGENOM:   HBG551298
- OMA:   ADNHLGY
- ProtClustDB:   CLSK876529
- BioCyc:   MMAR267377:MMP1340-MONOMER
- InterPro:   IPR004843

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 43264; Mature: 43264

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: ACT_SITE 85-85

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNA
CCEEEECCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHH
IRCAMEGLLKLKEKNIPIYLIHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFN
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHCCCCHHHHHHHHCCHHHHCCCCCCEEEC
NEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLFHQSVNPFIPQSFEMQVTDFP
CCEEEEHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHEEEEECCCCCCCCCCCEEEECCCC
DDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFD
CCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCEEHHHHHHHHHCCCEEEEECCCCCCC
INSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDE
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHH
IANLTLYKRISRIDENLEESLIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDS
HHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
LLYVNDYFKGNY
EEEEECCCCCCC
>Mature Secondary Structure
MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNA
CCEEEECCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHH
IRCAMEGLLKLKEKNIPIYLIHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFN
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHCCCCHHHHHHHHCCHHHHCCCCCCEEEC
NEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLFHQSVNPFIPQSFEMQVTDFP
CCEEEEHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHEEEEECCCCCCCCCCCEEEECCCC
DDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFD
CCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCEEHHHHHHHHHCCCEEEEECCCCCCC
INSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDE
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHH
IANLTLYKRISRIDENLEESLIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDS
HHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
LLYVNDYFKGNY
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA