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The map label for this gene is map [H]

Identifier: 37680742

GI number: 37680742

Start: 2587397

End: 2588275

Strand: Direct

Name: map [H]

Synonym: VV2558

Alternate gene names: 37680742

Gene position: 2587397-2588275 (Clockwise)

Preceding gene: 37680723

Following gene: 37680743

Centisome position: 77.13

GC content: 43.69

Gene sequence:

>879_bases
ATGTCAATTAAGATTAAAACTACTCAGCAAATTGAGCGCATGAGAATGGCCGGTAAACTGGCCGCAGAAATCCTGGAAAT
GATTGAGCCATACATCAAGGAAGGGGTGACAACAGATGAACTGAATCAGATTTGTCACGATTACGCTCTAGAAAAAGGTG
CTTACTCTGCTCCATTGGATTACCACGGTTTTCCTAAATCGATTTGCACGTCAATCAACCATATTGTTTGCCACGGCATT
CCAGCATCAAAAGATGAAATCGGTAGCAACGGCCAAATGAAACCTGCAATTTTGAAAAATGGCGATATCGTTAACGTTGA
TATCACCGTCATTGTGCCTGACGATGAAAAAGCCGATTTGTCTGTTCGTCCTCAAGGTTTCCACGGTGATACATCAAAAA
TGTTCCTAGTTGGCGACGTTTCTCCAGCCAACAAACGCCTTTGCATGGTGGCACAAGAAGCCCTGTACATCGGTATGCGT
CAAGTTAAACCGGGTGCTACCGTGGGTGATATTGGTACCGCGATCGAGAAATACATCAAAGACAATAATAAAAACAACCC
ACGCAATAAGTTCTCTATTGTGAAAGATTTCTGTGGTCACGGCATTGGTGATGAGTTCCACGAAGAACCTCAAGTCGTTC
ATTACCGCAATAGCGATCGTCGTGTGTTAAAAGAAGGCATGTGTTTTACTATCGAGCCGATGATCAATGCAGGTAAATTC
GGTTGTACTGTCGATGCTGAAGATGATTGGACGGTTTACACTGGTGACGGTAAAAATTCAGCACAGTGGGAACACACGAT
TCTCGTCACTAAAGAGGGTTGTGAAGTGCTCACTCTGCGCAGTGAAGAATCCATTCCTCGCCTTATGAAGAATATCTAA

Upstream 100 bases:

>100_bases
ATACTCTCGTTTTTCAGACAAATACACATTCTCATTTCTTCCTGTTAGAATGCCGCATCAGCACACTCTGATGTGCCCCC
GAATTAAGTAGAGAAAGCCA

Downstream 100 bases:

>100_bases
TCCCATCGGATCATTTCGTTTTTCTATCCCCGCCTACGCGGGGATATTTTTTATCAGTCGCAACTCTGTTACATTCTTTA
GCAGATAACGATTGCACGGA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSIKIKTTQQIERMRMAGKLAAEILEMIEPYIKEGVTTDELNQICHDYALEKGAYSAPLDYHGFPKSICTSINHIVCHGI
PASKDEIGSNGQMKPAILKNGDIVNVDITVIVPDDEKADLSVRPQGFHGDTSKMFLVGDVSPANKRLCMVAQEALYIGMR
QVKPGATVGDIGTAIEKYIKDNNKNNPRNKFSIVKDFCGHGIGDEFHEEPQVVHYRNSDRRVLKEGMCFTIEPMINAGKF
GCTVDAEDDWTVYTGDGKNSAQWEHTILVTKEGCEVLTLRSEESIPRLMKNI

Sequences:

>Translated_292_residues
MSIKIKTTQQIERMRMAGKLAAEILEMIEPYIKEGVTTDELNQICHDYALEKGAYSAPLDYHGFPKSICTSINHIVCHGI
PASKDEIGSNGQMKPAILKNGDIVNVDITVIVPDDEKADLSVRPQGFHGDTSKMFLVGDVSPANKRLCMVAQEALYIGMR
QVKPGATVGDIGTAIEKYIKDNNKNNPRNKFSIVKDFCGHGIGDEFHEEPQVVHYRNSDRRVLKEGMCFTIEPMINAGKF
GCTVDAEDDWTVYTGDGKNSAQWEHTILVTKEGCEVLTLRSEESIPRLMKNI
>Mature_291_residues
SIKIKTTQQIERMRMAGKLAAEILEMIEPYIKEGVTTDELNQICHDYALEKGAYSAPLDYHGFPKSICTSINHIVCHGIP
ASKDEIGSNGQMKPAILKNGDIVNVDITVIVPDDEKADLSVRPQGFHGDTSKMFLVGDVSPANKRLCMVAQEALYIGMRQ
VKPGATVGDIGTAIEKYIKDNNKNNPRNKFSIVKDFCGHGIGDEFHEEPQVVHYRNSDRRVLKEGMCFTIEPMINAGKFG
CTVDAEDDWTVYTGDGKNSAQWEHTILVTKEGCEVLTLRSEESIPRLMKNI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=291, Percent_Identity=39.1752577319588, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI40385867, Length=283, Percent_Identity=36.7491166077738, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI1786364, Length=293, Percent_Identity=51.1945392491468, Blast_Score=291, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI71996291, Length=292, Percent_Identity=41.0958904109589, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323273, Length=285, Percent_Identity=38.9473684210526, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21355531, Length=284, Percent_Identity=41.9014084507042, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24583427, Length=277, Percent_Identity=38.2671480144404, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32462; Mature: 32330

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKIKTTQQIERMRMAGKLAAEILEMIEPYIKEGVTTDELNQICHDYALEKGAYSAPLD
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
YHGFPKSICTSINHIVCHGIPASKDEIGSNGQMKPAILKNGDIVNVDITVIVPDDEKADL
CCCCCHHHHHHHHHEEEECCCCCHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCCCCCC
SVRPQGFHGDTSKMFLVGDVSPANKRLCMVAQEALYIGMRQVKPGATVGDIGTAIEKYIK
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DNNKNNPRNKFSIVKDFCGHGIGDEFHEEPQVVHYRNSDRRVLKEGMCFTIEPMINAGKF
CCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCHHHHHCCCCEEEECCCCCCCC
GCTVDAEDDWTVYTGDGKNSAQWEHTILVTKEGCEVLTLRSEESIPRLMKNI
CEEEECCCCEEEEECCCCCCCCEEEEEEEEECCCEEEEECCHHHHHHHHHCC
>Mature Secondary Structure 
SIKIKTTQQIERMRMAGKLAAEILEMIEPYIKEGVTTDELNQICHDYALEKGAYSAPLD
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
YHGFPKSICTSINHIVCHGIPASKDEIGSNGQMKPAILKNGDIVNVDITVIVPDDEKADL
CCCCCHHHHHHHHHEEEECCCCCHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCCCCCC
SVRPQGFHGDTSKMFLVGDVSPANKRLCMVAQEALYIGMRQVKPGATVGDIGTAIEKYIK
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DNNKNNPRNKFSIVKDFCGHGIGDEFHEEPQVVHYRNSDRRVLKEGMCFTIEPMINAGKF
CCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCHHHHHCCCCEEEECCCCCCCC
GCTVDAEDDWTVYTGDGKNSAQWEHTILVTKEGCEVLTLRSEESIPRLMKNI
CEEEECCCCEEEEECCCCCCCCEEEEEEEEECCCEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]