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The map label for this gene is aaeR [H]

Identifier: 37680602

GI number: 37680602

Start: 2446034

End: 2446921

Strand: Direct

Name: aaeR [H]

Synonym: VV2418

Alternate gene names: 37680602

Gene position: 2446034-2446921 (Clockwise)

Preceding gene: 37680597

Following gene: 37680608

Centisome position: 72.92

GC content: 46.51

Gene sequence:

>888_bases
GTGTCAGGAAATATGAAATTAGACGATCTCAACCTGTTCAGACTCGTTGTTGAAAATGGGAGCTACACCGCAACTTCACG
TAAGACCATGATCCCCGTGGCGACCATCACCCGACGCATACAAGCTTTGGAAGATGCGGTGAACTTGCGCCTTCTCAATC
GCCATGCACGTAAATTATCACTGACAGAAGCGGGAGAACGCTTTTTCCGTGAATGCTCTCCTTTACTGCAAAGACTCACA
AACACAGCCGAAGAAATTACCGATGAATGTCGTGGTGCGTCTGGCAAAATCAAGATTTCAACGCCCTACAATCTCACCAA
GCGCATGATGATGCCAATGTTGAACGGTTTTATGAGTCAGTATCCAGAAATCAACATTGAACTCACTACAGAGAGTAACG
CTGATCAACTTGACCCAACCGAATGGGATGTCATTTTCCGCGTAGGACCACAAAGAGATTCAAGCCTTATCGCGCGTAAA
ATTGGTTCGGTAAAAGATATTTTGGTGGCTAGCCCTGAGTACGTAAACGCTCACCCAATGCCAACTCATGCTGAAGATCT
GCACGACCACTTCCTACTCAAAGGCCACCCGCTGTTAAAGTGGACATTAATCAACAGCAAAGGCGAAACCGTTGTTAACG
TTGATCGTGGTCGCTTTCAAGCCAACGCACTGAATGTGGTACGTAGCGCGTGCTCAGAAGGGCTAGGCATCACTCTCATG
CCAGACGTGATGATAAAAGAGTATATCGCCGATGGCAGCCTAGTGCGTATTCTGCCTGACTGGAGTGCAAACCCACGCGA
TATTTACATGCTCTACAATCACAAAGATCACTTACCCGAAAAAGTGCGTTTGTTTATCGACTACGTGATTGCTTATAACA
TCCACTAA

Upstream 100 bases:

>100_bases
CTACTAGATGTATGCTGATCACAAATCGTGCGACCTGTTGACATGAAGCAAACTTTCATCGCAAAGTTAGCGCTAAATTA
GGCCTATTTGGTAAATAGAT

Downstream 100 bases:

>100_bases
CAATGTAGCGCGTAATCATAGAGGTTATTTCGAGCACAAAAAAACCAGAGCAGAAACGCTCTGGTTTTTATTTGTCTTAT
CTTAACCCTGAACTCCGGTG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSGNMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDAVNLRLLNRHARKLSLTEAGERFFRECSPLLQRLT
NTAEEITDECRGASGKIKISTPYNLTKRMMMPMLNGFMSQYPEINIELTTESNADQLDPTEWDVIFRVGPQRDSSLIARK
IGSVKDILVASPEYVNAHPMPTHAEDLHDHFLLKGHPLLKWTLINSKGETVVNVDRGRFQANALNVVRSACSEGLGITLM
PDVMIKEYIADGSLVRILPDWSANPRDIYMLYNHKDHLPEKVRLFIDYVIAYNIH

Sequences:

>Translated_295_residues
MSGNMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDAVNLRLLNRHARKLSLTEAGERFFRECSPLLQRLT
NTAEEITDECRGASGKIKISTPYNLTKRMMMPMLNGFMSQYPEINIELTTESNADQLDPTEWDVIFRVGPQRDSSLIARK
IGSVKDILVASPEYVNAHPMPTHAEDLHDHFLLKGHPLLKWTLINSKGETVVNVDRGRFQANALNVVRSACSEGLGITLM
PDVMIKEYIADGSLVRILPDWSANPRDIYMLYNHKDHLPEKVRLFIDYVIAYNIH
>Mature_294_residues
SGNMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDAVNLRLLNRHARKLSLTEAGERFFRECSPLLQRLTN
TAEEITDECRGASGKIKISTPYNLTKRMMMPMLNGFMSQYPEINIELTTESNADQLDPTEWDVIFRVGPQRDSSLIARKI
GSVKDILVASPEYVNAHPMPTHAEDLHDHFLLKGHPLLKWTLINSKGETVVNVDRGRFQANALNVVRSACSEGLGITLMP
DVMIKEYIADGSLVRILPDWSANPRDIYMLYNHKDHLPEKVRLFIDYVIAYNIH

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=28.7671232876712, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87081978, Length=290, Percent_Identity=28.6206896551724, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786401, Length=287, Percent_Identity=29.2682926829268, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=26.1168384879725, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787589, Length=288, Percent_Identity=26.3888888888889, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1789440, Length=288, Percent_Identity=26.3888888888889, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787128, Length=291, Percent_Identity=27.4914089347079, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789173, Length=286, Percent_Identity=24.1258741258741, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI157672245, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790783, Length=254, Percent_Identity=26.3779527559055, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787601, Length=128, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33522; Mature: 33391

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDAVNLRLLNRHARKLS
CCCCCCCCCHHEEEEEEECCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTEAGERFFRECSPLLQRLTNTAEEITDECRGASGKIKISTPYNLTKRMMMPMLNGFMSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
YPEINIELTTESNADQLDPTEWDVIFRVGPQRDSSLIARKIGSVKDILVASPEYVNAHPM
CCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHEEECCCCCCCCCC
PTHAEDLHDHFLLKGHPLLKWTLINSKGETVVNVDRGRFQANALNVVRSACSEGLGITLM
CCCHHHHHHHHEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEC
PDVMIKEYIADGSLVRILPDWSANPRDIYMLYNHKDHLPEKVRLFIDYVIAYNIH
HHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
SGNMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDAVNLRLLNRHARKLS
CCCCCCCCHHEEEEEEECCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTEAGERFFRECSPLLQRLTNTAEEITDECRGASGKIKISTPYNLTKRMMMPMLNGFMSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
YPEINIELTTESNADQLDPTEWDVIFRVGPQRDSSLIARKIGSVKDILVASPEYVNAHPM
CCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCHHHHEEECCCCCCCCCC
PTHAEDLHDHFLLKGHPLLKWTLINSKGETVVNVDRGRFQANALNVVRSACSEGLGITLM
CCCHHHHHHHHEECCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEC
PDVMIKEYIADGSLVRILPDWSANPRDIYMLYNHKDHLPEKVRLFIDYVIAYNIH
HHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]