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The map label for this gene is aqpZ [H]

Identifier: 37680588

GI number: 37680588

Start: 2434367

End: 2435062

Strand: Direct

Name: aqpZ [H]

Synonym: VV2404

Alternate gene names: 37680588

Gene position: 2434367-2435062 (Clockwise)

Preceding gene: 37680587

Following gene: 37680589

Centisome position: 72.57

GC content: 52.87

Gene sequence:

>696_bases
ATGAATAAATATCTGGCGGAATTATTTGGCACCTTTTGGCTGGTGCTTGGTGGATGTGGCAGTGCCGTGTTGGCGGCCGC
CTTTCCGGACGTTGGGATTGGCCTGCTAGGCGTATCCCTCGCGTTCGGTTTGACGGTGCTCACCATGGCTTTTGCTATCG
GCCATATTTCCGGCTGCCACTTGAACCCTGCCGTCACCATTGGCTTATGGGCCGGTGGTCGATTTGAAGCCAAAGAAATT
GTTCCTTATATCCTTGCTCAAGTGATTGGTGGCGTCATTGCCGGTGGTGTGCTTTATACCATCGCCTCTGGTCAAATGGG
CTTCGATGCGACGAGCTCGGGTTTTGCCTCTAATGGTTATGGTGAGCATTCTCCCGGTGGCTATTCGCTGACTTCTGCGC
TGGTGACCGAAATCGTGATGGCCATGATGTTTTTGCTGGTGATTCTTGGCGCAACAGATCAGCGTGCACCTCAAGGTTTT
GCGCCCATCGCTATCGGTCTGTGCCTCACACTTATCCACCTCATCAGCATTCCAGTGACCAATACATCGGTCAACCCTGC
TCGAAGTACCGGCGTTGCTCTCTATGTTGGCGATTGGGCCACCGCGCAACTTTGGCTATTCTGGGTTGCGCCGATTTTAG
GCGCACTACTAGGGGCTGTGGCCTACAAGTTGATTTCAGGGTCTAACAAAGACTAA

Upstream 100 bases:

>100_bases
CCAAGTAGAATTTCGCGACACAATATCACGACACTTTCTAGCAAGGTGCTGATTGTCAGCTATTTTTATTCCAATACTCC
CCCTCTCAATAGGACATTGT

Downstream 100 bases:

>100_bases
TCACAGCGAGCCGCCGATTCGAGCGGCTCTTTTTCTATTGCTTCTTAATATTTTATAAAACACATCACAACTTTGTGACT
TGGTCACAAATGGTCACAGA

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEI
VPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEIVMAMMFLLVILGATDQRAPQGF
APIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD

Sequences:

>Translated_231_residues
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEI
VPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEIVMAMMFLLVILGATDQRAPQGF
APIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
>Mature_231_residues
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVTIGLWAGGRFEAKEI
VPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGYGEHSPGGYSLTSALVTEIVMAMMFLLVILGATDQRAPQGF
APIAIGLCLTLIHLISIPVTNTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=191, Percent_Identity=37.696335078534, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4502183, Length=225, Percent_Identity=34.6666666666667, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4502179, Length=223, Percent_Identity=31.8385650224215, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI6912506, Length=223, Percent_Identity=32.7354260089686, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI4755125, Length=198, Percent_Identity=32.3232323232323, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502181, Length=198, Percent_Identity=32.3232323232323, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI86792455, Length=226, Percent_Identity=28.7610619469027, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI157266307, Length=239, Percent_Identity=28.8702928870293, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=26.5060240963855, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45446752, Length=205, Percent_Identity=28.2926829268293, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4502187, Length=251, Percent_Identity=27.8884462151394, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI22538420, Length=248, Percent_Identity=27.0161290322581, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI297307120, Length=91, Percent_Identity=38.4615384615385, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=75, Blast_Score=314, Evalue=3e-87,
Organism=Escherichia coli, GI1790362, Length=251, Percent_Identity=28.2868525896414, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=207, Percent_Identity=28.9855072463768, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=237, Percent_Identity=27.8481012658228, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=244, Percent_Identity=27.8688524590164, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24652747, Length=228, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45551084, Length=228, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24652751, Length=191, Percent_Identity=35.6020942408377, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922038, Length=191, Percent_Identity=35.6020942408377, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550503, Length=230, Percent_Identity=28.695652173913, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136672, Length=231, Percent_Identity=26.8398268398268, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24762342, Length=200, Percent_Identity=27, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762346, Length=228, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24762348, Length=228, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20130305, Length=228, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24762344, Length=228, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23752; Mature: 23752

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCH
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVTIGLWAGGRFEAKEIVPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGY
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GEHSPGGYSLTSALVTEIVMAMMFLLVILGATDQRAPQGFAPIAIGLCLTLIHLISIPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNKYLAELFGTFWLVLGGCGSAVLAAAFPDVGIGLLGVSLAFGLTVLTMAFAIGHISGCH
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVTIGLWAGGRFEAKEIVPYILAQVIGGVIAGGVLYTIASGQMGFDATSSGFASNGY
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GEHSPGGYSLTSALVTEIVMAMMFLLVILGATDQRAPQGFAPIAIGLCLTLIHLISIPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVALYVGDWATAQLWLFWVAPILGALLGAVAYKLISGSNKD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA