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The map label for this gene is yogA [H]

Identifier: 37521518

GI number: 37521518

Start: 2075323

End: 2076333

Strand: Reverse

Name: yogA [H]

Synonym: gll1949

Alternate gene names: 37521518

Gene position: 2076333-2075323 (Counterclockwise)

Preceding gene: 37521519

Following gene: 37521517

Centisome position: 44.57

GC content: 67.85

Gene sequence:

>1011_bases
ATGCAAAAAGTAATCGTCGAAGCGTTTGGGGGGGTCGAGCGGCTGCACCTGGCCGCCTTGCCCGACCCCTGCCCGACCGG
GCAGCAGGTGCTGGTGCGGCTGACCAGCATCGGCATGAACCACGCCGACTTGATGGCGCGCCGCGGCGAGTACCGGCTTT
CTTCAGGAGAGCCGCCCTTCACCCCCGGCCTGGAAGGTGGCGGCTACATCGAGGCTGTCGGGCCCGCAGTGCACGACCGG
CACGTCGGCCAACGGGTGCTGCTCAGCCTCGACGCGCCGGTCCACCCTGAGGGCCGGGTCGGAACCTACGGCACGCACTA
CTTGACGAGCGCCGCACAGACGGTGATTGCCCCCGACGCCCTGCCCGACCAGCTGCTGGGGGCGCTCTGGCTGGCGTACC
TGACGGCCTGGAGTTGTCTTATCTGGCGCCAGGGCCTCAGAGCCGGTCAAGTGGTGCTGTTGCCCGCCGCGAGCAGCAGC
GTCGCCATCGCCGCCGCCCAGATCGTCCGCCACCATGGCGGCGTGGCGATCGGCACCACGACCAGCGCCCTCAAGTGCGA
AAAGCTGCAGGCGATGGGCGAATCCGCCTACGCCCAGATCGTGTGCACCGGCGAGCGCCAGTGGCGCAAGCAGGTCAAAA
AGCTCACCGACAACCGCGGCGTCGATGTGGTCTTCGACCCCGTGGGGGCCGGGCCGTTGTTGCAATCGGCGATCCACCTG
CTCGCGGAGGGCGGAACGATCTGGATCTACGGCCTGCTGGGCAAACCGGACGTGCTGGATGTCACACCGCTGATTCGCAA
GCGCGCCGCCCTGCGCGGGTGGCTGCTCGACGAATTGAGCGCCCTGGGAAGCGAGCCGGTGCAAAGGGCCTACCAACACG
TTCTCGATCGGTTTGCAGATGGTACCTACGCGCTGCCGATAGCGGGAATCTTCCCGCTGCGGGACGTCCGCGAAGCCCAC
GCGCGGATGGAGCGGGGCGCACACATCGGCAAGTTCATCCTGGTGCCCTGA

Upstream 100 bases:

>100_bases
GGTTGCGCCCGCAGGCCGCGGCCGCCGACCCCGAAGCGAGCGGCGTCGAGGTCGAGCACCATGCCAACGGCGGCGCGCCG
GCGGCTGCAGGAGCCTTGCC

Downstream 100 bases:

>100_bases
AGATGACAAAAAGCTCAGGAAAACCACAGATGGCGACAGCAACCCGGACGGCCGACAACCTGGTCGAGGCCCTCAGGCGG
TGGGCTTCCGTGCGCTCCGC

Product: oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MQKVIVEAFGGVERLHLAALPDPCPTGQQVLVRLTSIGMNHADLMARRGEYRLSSGEPPFTPGLEGGGYIEAVGPAVHDR
HVGQRVLLSLDAPVHPEGRVGTYGTHYLTSAAQTVIAPDALPDQLLGALWLAYLTAWSCLIWRQGLRAGQVVLLPAASSS
VAIAAAQIVRHHGGVAIGTTTSALKCEKLQAMGESAYAQIVCTGERQWRKQVKKLTDNRGVDVVFDPVGAGPLLQSAIHL
LAEGGTIWIYGLLGKPDVLDVTPLIRKRAALRGWLLDELSALGSEPVQRAYQHVLDRFADGTYALPIAGIFPLRDVREAH
ARMERGAHIGKFILVP

Sequences:

>Translated_336_residues
MQKVIVEAFGGVERLHLAALPDPCPTGQQVLVRLTSIGMNHADLMARRGEYRLSSGEPPFTPGLEGGGYIEAVGPAVHDR
HVGQRVLLSLDAPVHPEGRVGTYGTHYLTSAAQTVIAPDALPDQLLGALWLAYLTAWSCLIWRQGLRAGQVVLLPAASSS
VAIAAAQIVRHHGGVAIGTTTSALKCEKLQAMGESAYAQIVCTGERQWRKQVKKLTDNRGVDVVFDPVGAGPLLQSAIHL
LAEGGTIWIYGLLGKPDVLDVTPLIRKRAALRGWLLDELSALGSEPVQRAYQHVLDRFADGTYALPIAGIFPLRDVREAH
ARMERGAHIGKFILVP
>Mature_336_residues
MQKVIVEAFGGVERLHLAALPDPCPTGQQVLVRLTSIGMNHADLMARRGEYRLSSGEPPFTPGLEGGGYIEAVGPAVHDR
HVGQRVLLSLDAPVHPEGRVGTYGTHYLTSAAQTVIAPDALPDQLLGALWLAYLTAWSCLIWRQGLRAGQVVLLPAASSS
VAIAAAQIVRHHGGVAIGTTTSALKCEKLQAMGESAYAQIVCTGERQWRKQVKKLTDNRGVDVVFDPVGAGPLLQSAIHL
LAEGGTIWIYGLLGKPDVLDVTPLIRKRAALRGWLLDELSALGSEPVQRAYQHVLDRFADGTYALPIAGIFPLRDVREAH
ARMERGAHIGKFILVP

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI18379349, Length=353, Percent_Identity=30.028328611898, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI194239674, Length=342, Percent_Identity=28.3625730994152, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13236495, Length=342, Percent_Identity=28.3625730994152, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI22538446, Length=341, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI22538444, Length=341, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI24308257, Length=353, Percent_Identity=24.929178470255, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI194239676, Length=182, Percent_Identity=33.5164835164835, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI28557745, Length=337, Percent_Identity=26.4094955489614, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790485, Length=343, Percent_Identity=25.0728862973761, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=254, Percent_Identity=25.9842519685039, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=346, Percent_Identity=24.5664739884393, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36116; Mature: 36116

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVIVEAFGGVERLHLAALPDPCPTGQQVLVRLTSIGMNHADLMARRGEYRLSSGEPPF
CCCCHHHHHCCHHEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCCC
TPGLEGGGYIEAVGPAVHDRHVGQRVLLSLDAPVHPEGRVGTYGTHYLTSAAQTVIAPDA
CCCCCCCCEEEECCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
LPDQLLGALWLAYLTAWSCLIWRQGLRAGQVVLLPAASSSVAIAAAQIVRHHGGVAIGTT
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECC
TSALKCEKLQAMGESAYAQIVCTGERQWRKQVKKLTDNRGVDVVFDPVGAGPLLQSAIHL
CHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
LAEGGTIWIYGLLGKPDVLDVTPLIRKRAALRGWLLDELSALGSEPVQRAYQHVLDRFAD
HHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GTYALPIAGIFPLRDVREAHARMERGAHIGKFILVP
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MQKVIVEAFGGVERLHLAALPDPCPTGQQVLVRLTSIGMNHADLMARRGEYRLSSGEPPF
CCCCHHHHHCCHHEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCCC
TPGLEGGGYIEAVGPAVHDRHVGQRVLLSLDAPVHPEGRVGTYGTHYLTSAAQTVIAPDA
CCCCCCCCEEEECCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
LPDQLLGALWLAYLTAWSCLIWRQGLRAGQVVLLPAASSSVAIAAAQIVRHHGGVAIGTT
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECC
TSALKCEKLQAMGESAYAQIVCTGERQWRKQVKKLTDNRGVDVVFDPVGAGPLLQSAIHL
CHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
LAEGGTIWIYGLLGKPDVLDVTPLIRKRAALRGWLLDELSALGSEPVQRAYQHVLDRFAD
HHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GTYALPIAGIFPLRDVREAHARMERGAHIGKFILVP
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]