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The map label for this gene is panC/cmk

Identifier: 37521375

GI number: 37521375

Start: 1924378

End: 1925925

Strand: Reverse

Name: panC/cmk

Synonym: gll1806

Alternate gene names: 37521375

Gene position: 1925925-1924378 (Counterclockwise)

Preceding gene: 37521376

Following gene: 37521374

Centisome position: 41.34

GC content: 66.8

Gene sequence:

>1548_bases
GTGAAAGTCGTCGAAACCGTGGCCAGGCTCGAAGCGTTCCGGCGGGCGCGCGCCCCGGTCGCCGGCGTGGAGATGGGGCT
GGTGATGACGATGGGGGCGTTGCACGAAGGCCACCGCAGCTTGATCGCCCGCGCTCGCCGTGAGAACACTGTGCTGGTGG
TCAGTATCTTTGTCAATCCCACCCAGTTCGGGTCGAGCGAAGACCTGAGCCGCTACCCGCGGCCCCTGGAAGCCGATCTT
GAACTCTGCCGCCACGAAGGGGTGGATCTCGTCTTTGCGCCGCCGGAGTCCGAACTCTACCCGCTGGGTTCCGGCACCAA
AGTAGTACCGGATCCGGCCCTCACCGAGGTGATGTGCGGACTCTCGCGCCCAGGCCACTTCAGCGGTGTGGCCACCGTCG
TGGCCAAGGTGATGAACTTGGTGCAGCCGGTGCGCGCCTACTTCGGCCAGAAAGACGCCCAGCAGGTGGCGGTGATCAAG
TCCGTCTGCTGCGATCTCAATATCGGCGGTCGCATCGTCGTCTGCCCGACCGTGCACGATCCGGATGGCCTTGCCCTGAG
TTCCCGCAATGTCTATTTGAGTTCTGCGCAACGGAGCACCGCCCTCGCTTTGCCCCGCGCCCTCGACAAAGCGGCCCATC
TGTGGGCAGGGGGCGAGCGGCAGGCGAGCGAACTGGAGCGCGCCGTCCGTTCGGTGCTCGCAAGCGAACCGGGCCTGGAG
ATCGAATACGTGGCGGCGGTGGATCCCGAGCGGCTCGCTCCCCGTCAGGACAACGCGGGACCGGTGCTGGTGGCGGCGGC
GGTGCGGGTCGGATCCACGCGTCTGATCGACAACGTCGTGCTGGGTCAGCACCACGAGCGCCGGCCGATTATCGCCATCG
ACGGACCCGCCGGAGCGGGCAAATCGACGCTCGCCCGCCGCCTGGCCCAGCGGCTCGGGTTTCTCTATATCGACACGGGG
GCGATGTACCGGGCGGTCACCTGGAGGGCCATGCAGGAGCGAATCGATCCCCTCGATGGGGAGCGGCTCAGCGCCCTGAC
CCGGGCGGTGCGCATCCGGCTTGCCCCCGGCTACCAGAGTGCCTTTCCCACCCGGGTGTGGGTGGATGGCGAAGAAGTGA
CCCGGGCGGTGCGCGATGAGGCGGTGTCGCTGCACGTGAGCGCCGTGTCTTCCCATCCGGGGGTGCGCAGCGAACTGGTT
GCCCAGCAGCGCCGCATCGGCGAAGCGGGGGGGGTCATCCTTGACGGCCGCGACATCGGCACCCACGTCTTTTCCCGGGC
GGAACTGAAAATTTATCTGACCGCCTCCGTCGAGGAGCGGGCGCTGCGCCGCGCGGACGACCTGAAGGCCAAAGGTTTGC
CGGTACCCGATATCGAAGTGCTCAAAGAGCAGATCCGCAGCCGCGACAACCAGGATATGAGCCGCGCCTACGCCCCCTTG
CGCAAGGCAGACGACGCCATCGAGGTCAACACCGACACCTTCACAGTCCAGGACACCCTCGACCGTTTGCTCGCCCTCTA
CCGCGACAAAGTGGGAGGCAGCGTCTGA

Upstream 100 bases:

>100_bases
TCAAAACCTACGCCAGCGCCAGTTCGCCGCTTACGGGACTGGTGGGGAGCGCTGTCGGCAGTTGAAGCCCACGGATGCCG
TCGGGTCGGGGGGGAACGCT

Downstream 100 bases:

>100_bases
ATCGGGCGTACCGGCAAGTACCGATTGTCGAATCCGGCGAGCCGCTGGTGGAGTTGCCGCCCGCTCTGCTGCGCTTCGAG
CCTCACCCCTACATCGCCCT

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Pantothenate synthetase; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MKVVETVARLEAFRRARAPVAGVEMGLVMTMGALHEGHRSLIARARRENTVLVVSIFVNPTQFGSSEDLSRYPRPLEADL
ELCRHEGVDLVFAPPESELYPLGSGTKVVPDPALTEVMCGLSRPGHFSGVATVVAKVMNLVQPVRAYFGQKDAQQVAVIK
SVCCDLNIGGRIVVCPTVHDPDGLALSSRNVYLSSAQRSTALALPRALDKAAHLWAGGERQASELERAVRSVLASEPGLE
IEYVAAVDPERLAPRQDNAGPVLVAAAVRVGSTRLIDNVVLGQHHERRPIIAIDGPAGAGKSTLARRLAQRLGFLYIDTG
AMYRAVTWRAMQERIDPLDGERLSALTRAVRIRLAPGYQSAFPTRVWVDGEEVTRAVRDEAVSLHVSAVSSHPGVRSELV
AQQRRIGEAGGVILDGRDIGTHVFSRAELKIYLTASVEERALRRADDLKAKGLPVPDIEVLKEQIRSRDNQDMSRAYAPL
RKADDAIEVNTDTFTVQDTLDRLLALYRDKVGGSV

Sequences:

>Translated_515_residues
MKVVETVARLEAFRRARAPVAGVEMGLVMTMGALHEGHRSLIARARRENTVLVVSIFVNPTQFGSSEDLSRYPRPLEADL
ELCRHEGVDLVFAPPESELYPLGSGTKVVPDPALTEVMCGLSRPGHFSGVATVVAKVMNLVQPVRAYFGQKDAQQVAVIK
SVCCDLNIGGRIVVCPTVHDPDGLALSSRNVYLSSAQRSTALALPRALDKAAHLWAGGERQASELERAVRSVLASEPGLE
IEYVAAVDPERLAPRQDNAGPVLVAAAVRVGSTRLIDNVVLGQHHERRPIIAIDGPAGAGKSTLARRLAQRLGFLYIDTG
AMYRAVTWRAMQERIDPLDGERLSALTRAVRIRLAPGYQSAFPTRVWVDGEEVTRAVRDEAVSLHVSAVSSHPGVRSELV
AQQRRIGEAGGVILDGRDIGTHVFSRAELKIYLTASVEERALRRADDLKAKGLPVPDIEVLKEQIRSRDNQDMSRAYAPL
RKADDAIEVNTDTFTVQDTLDRLLALYRDKVGGSV
>Mature_515_residues
MKVVETVARLEAFRRARAPVAGVEMGLVMTMGALHEGHRSLIARARRENTVLVVSIFVNPTQFGSSEDLSRYPRPLEADL
ELCRHEGVDLVFAPPESELYPLGSGTKVVPDPALTEVMCGLSRPGHFSGVATVVAKVMNLVQPVRAYFGQKDAQQVAVIK
SVCCDLNIGGRIVVCPTVHDPDGLALSSRNVYLSSAQRSTALALPRALDKAAHLWAGGERQASELERAVRSVLASEPGLE
IEYVAAVDPERLAPRQDNAGPVLVAAAVRVGSTRLIDNVVLGQHHERRPIIAIDGPAGAGKSTLARRLAQRLGFLYIDTG
AMYRAVTWRAMQERIDPLDGERLSALTRAVRIRLAPGYQSAFPTRVWVDGEEVTRAVRDEAVSLHVSAVSSHPGVRSELV
AQQRRIGEAGGVILDGRDIGTHVFSRAELKIYLTASVEERALRRADDLKAKGLPVPDIEVLKEQIRSRDNQDMSRAYAPL
RKADDAIEVNTDTFTVQDTLDRLLALYRDKVGGSV

Specific function: Pantothenate biosynthesis; last step. [C]

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786325, Length=280, Percent_Identity=42.1428571428571, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787139, Length=224, Percent_Identity=37.0535714285714, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322046, Length=309, Percent_Identity=37.2168284789644, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANCY_GLOVI (Q7NJM6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924752.1
- ProteinModelPortal:   Q7NJM6
- GeneID:   2600208
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll1806
- NMPDR:   fig|251221.1.peg.1806
- HOGENOM:   HBG428839
- OMA:   LGEKDWQ
- ProtClustDB:   PRK13477
- BioCyc:   GVIO251221:GLL1806-MONOMER
- BRENDA:   2.7.4.14
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_01349
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00017
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase

EC number: =6.3.2.1; =2.7.4.14

Molecular weight: Translated: 56061; Mature: 56061

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVETVARLEAFRRARAPVAGVEMGLVMTMGALHEGHRSLIARARRENTVLVVSIFVNP
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
TQFGSSEDLSRYPRPLEADLELCRHEGVDLVFAPPESELYPLGSGTKVVPDPALTEVMCG
CCCCCCCHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEECCCCCEECCCHHHHHHHHC
LSRPGHFSGVATVVAKVMNLVQPVRAYFGQKDAQQVAVIKSVCCDLNIGGRIVVCPTVHD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PDGLALSSRNVYLSSAQRSTALALPRALDKAAHLWAGGERQASELERAVRSVLASEPGLE
CCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
IEYVAAVDPERLAPRQDNAGPVLVAAAVRVGSTRLIDNVVLGQHHERRPIIAIDGPAGAG
EEEEEECCHHHCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCCC
KSTLARRLAQRLGFLYIDTGAMYRAVTWRAMQERIDPLDGERLSALTRAVRIRLAPGYQS
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCC
AFPTRVWVDGEEVTRAVRDEAVSLHVSAVSSHPGVRSELVAQQRRIGEAGGVILDGRDIG
CCCCEEEECHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCHH
THVFSRAELKIYLTASVEERALRRADDLKAKGLPVPDIEVLKEQIRSRDNQDMSRAYAPL
HHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
RKADDAIEVNTDTFTVQDTLDRLLALYRDKVGGSV
HHCCCCEEECCCEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVVETVARLEAFRRARAPVAGVEMGLVMTMGALHEGHRSLIARARRENTVLVVSIFVNP
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
TQFGSSEDLSRYPRPLEADLELCRHEGVDLVFAPPESELYPLGSGTKVVPDPALTEVMCG
CCCCCCCHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEECCCCCEECCCHHHHHHHHC
LSRPGHFSGVATVVAKVMNLVQPVRAYFGQKDAQQVAVIKSVCCDLNIGGRIVVCPTVHD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
PDGLALSSRNVYLSSAQRSTALALPRALDKAAHLWAGGERQASELERAVRSVLASEPGLE
CCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
IEYVAAVDPERLAPRQDNAGPVLVAAAVRVGSTRLIDNVVLGQHHERRPIIAIDGPAGAG
EEEEEECCHHHCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCCCCCEEEEECCCCCC
KSTLARRLAQRLGFLYIDTGAMYRAVTWRAMQERIDPLDGERLSALTRAVRIRLAPGYQS
HHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCC
AFPTRVWVDGEEVTRAVRDEAVSLHVSAVSSHPGVRSELVAQQRRIGEAGGVILDGRDIG
CCCCEEEECHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCHH
THVFSRAELKIYLTASVEERALRRADDLKAKGLPVPDIEVLKEQIRSRDNQDMSRAYAPL
HHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
RKADDAIEVNTDTFTVQDTLDRLLALYRDKVGGSV
HHCCCCEEECCCEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292