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The map label for this gene is rmlA1 [H]

Identifier: 37521352

GI number: 37521352

Start: 1897569

End: 1898444

Strand: Reverse

Name: rmlA1 [H]

Synonym: gll1783

Alternate gene names: 37521352

Gene position: 1898444-1897569 (Counterclockwise)

Preceding gene: 37521353

Following gene: 37521351

Centisome position: 40.75

GC content: 63.47

Gene sequence:

>876_bases
ATGAAAGGGATCATATTGGCTGGGGGCAAGGGCACGCGGCTCTACCCCCTCACCCTGGGGGTCAGCAAACAACTGCTGCC
CGTCTACGACAAACCGATGATCTACTACCCGCTGGCCACCCTGATGCTCGCCGGCATCCGCGAGGTGCTGCTCATCTCCA
CCCCCCGCGACCTGCCCGCCTACCAAGAACTGCTCGGCGACGGCTCGCGCTACGGCATCGAGATCCGCTACTGCGTCCAG
CCGAGCCCCGACGGCCTCGCCCAGGCCTTCGTCCTCGGACGCGAGTTTTTGGAGGGCGGCCCGGCCTGTCTGATCTTGGG
CGACAACATCTTCTATGGCTACGGCCTGGGCGAAATGCTTCAAAAAGCGGCCACCCGCACGTTCGGCTCGACGATCTTTG
CCTACCGCGTCTCGGACCCAGAGCGCTACGGGGTGGTGGAGTACGACGAGCAAGGGCGGGTGCTGTCGATCGACGAGAAG
CCCAAAGCGCCGAAGTCCAACTACGCGGTGGTCGGTCTGTATTTTTACGACGCACAGATAAGCGAGATCGCCGCGGGGGT
GAAGCCCTCGGCGCGGGGGGAACTGGAGATCACCGACGTCAACAACGCCTACCTGGAGCGGGGGTTGTTGCGGGTGGAGC
GTCTCGGTCGGGGGATGGCGTGGCTGGACACCGGCACGCACGAGTCGCTGTTGCAGGCGTCGAATTTTATCGAGACGATC
GAGAAGCGGCAGGGTTTGAAGGTGGCGTGTCTGGAGGAGATCGCCTACCAGATGGGTCACATCGGTGTCGAGGCGGTGCT
GGAGCAGGCGGGGCGGCTGGGCAAGACCGAGTACGGCCAGTACCTCAGAAACCTTGTCGAGAAGACAAACCGCTAG

Upstream 100 bases:

>100_bases
GCAAGCTGGATCTGCCGCCTTACTCCATTACCCGTCTGTCGTTGCCGTGAGCTGCACCCGGCCAGGCCGGCACCACCCAA
CCACCGAGGAAACTACTGCG

Downstream 100 bases:

>100_bases
AACCCTCCCGCTTCGCAACACCCATTGACTTTACAGGAGCAAAGCGATGAAAGCATTTGTGCTTGCCGCCGGCAAAGGCA
CCCGCCTGCGCCCCTTCACC

Product: glucose 1-phosphate thymidyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGKGTRLYPLTLGVSKQLLPVYDKPMIYYPLATLMLAGIREVLLISTPRDLPAYQELLGDGSRYGIEIRYCVQ
PSPDGLAQAFVLGREFLEGGPACLILGDNIFYGYGLGEMLQKAATRTFGSTIFAYRVSDPERYGVVEYDEQGRVLSIDEK
PKAPKSNYAVVGLYFYDAQISEIAAGVKPSARGELEITDVNNAYLERGLLRVERLGRGMAWLDTGTHESLLQASNFIETI
EKRQGLKVACLEEIAYQMGHIGVEAVLEQAGRLGKTEYGQYLRNLVEKTNR

Sequences:

>Translated_291_residues
MKGIILAGGKGTRLYPLTLGVSKQLLPVYDKPMIYYPLATLMLAGIREVLLISTPRDLPAYQELLGDGSRYGIEIRYCVQ
PSPDGLAQAFVLGREFLEGGPACLILGDNIFYGYGLGEMLQKAATRTFGSTIFAYRVSDPERYGVVEYDEQGRVLSIDEK
PKAPKSNYAVVGLYFYDAQISEIAAGVKPSARGELEITDVNNAYLERGLLRVERLGRGMAWLDTGTHESLLQASNFIETI
EKRQGLKVACLEEIAYQMGHIGVEAVLEQAGRLGKTEYGQYLRNLVEKTNR
>Mature_291_residues
MKGIILAGGKGTRLYPLTLGVSKQLLPVYDKPMIYYPLATLMLAGIREVLLISTPRDLPAYQELLGDGSRYGIEIRYCVQ
PSPDGLAQAFVLGREFLEGGPACLILGDNIFYGYGLGEMLQKAATRTFGSTIFAYRVSDPERYGVVEYDEQGRVLSIDEK
PKAPKSNYAVVGLYFYDAQISEIAAGVKPSARGELEITDVNNAYLERGLLRVERLGRGMAWLDTGTHESLLQASNFIETI
EKRQGLKVACLEEIAYQMGHIGVEAVLEQAGRLGKTEYGQYLRNLVEKTNR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=182, Percent_Identity=29.6703296703297, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI11761619, Length=182, Percent_Identity=29.6703296703297, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=63.3217993079585, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1790224, Length=291, Percent_Identity=63.2302405498282, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133931050, Length=181, Percent_Identity=30.939226519337, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355443, Length=191, Percent_Identity=29.8429319371728, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644084, Length=191, Percent_Identity=29.8429319371728, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32189; Mature: 32189

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGKGTRLYPLTLGVSKQLLPVYDKPMIYYPLATLMLAGIREVLLISTPRDLPA
CCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHH
YQELLGDGSRYGIEIRYCVQPSPDGLAQAFVLGREFLEGGPACLILGDNIFYGYGLGEML
HHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEECCHHHHH
QKAATRTFGSTIFAYRVSDPERYGVVEYDEQGRVLSIDEKPKAPKSNYAVVGLYFYDAQI
HHHHHHHHCCEEEEEECCCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
SEIAAGVKPSARGELEITDVNNAYLERGLLRVERLGRGMAWLDTGTHESLLQASNFIETI
HHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
EKRQGLKVACLEEIAYQMGHIGVEAVLEQAGRLGKTEYGQYLRNLVEKTNR
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIILAGGKGTRLYPLTLGVSKQLLPVYDKPMIYYPLATLMLAGIREVLLISTPRDLPA
CCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHH
YQELLGDGSRYGIEIRYCVQPSPDGLAQAFVLGREFLEGGPACLILGDNIFYGYGLGEML
HHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEECCHHHHH
QKAATRTFGSTIFAYRVSDPERYGVVEYDEQGRVLSIDEKPKAPKSNYAVVGLYFYDAQI
HHHHHHHHCCEEEEEECCCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
SEIAAGVKPSARGELEITDVNNAYLERGLLRVERLGRGMAWLDTGTHESLLQASNFIETI
HHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
EKRQGLKVACLEEIAYQMGHIGVEAVLEQAGRLGKTEYGQYLRNLVEKTNR
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]