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The map label for this gene is 37521123

Identifier: 37521123

GI number: 37521123

Start: 1674563

End: 1676338

Strand: Direct

Name: 37521123

Synonym: glr1554

Alternate gene names: NA

Gene position: 1674563-1676338 (Clockwise)

Preceding gene: 37521121

Following gene: 37521124

Centisome position: 35.94

GC content: 64.25

Gene sequence:

>1776_bases
GTGTTAAGCTCGGGGCAATCGTTGAGACCTCGGGTGGTGGCGATGCGCTTGCGCAAATGGTGGACGGCGCTGTTGGGCTG
GATGGCACTCGCGCTCGCTGGCACAGCGGCCCTCGCCGAACCGATGACCCTCCCGCAAGAAGCGGTGATCGCTTTTCGTG
ACCCGGTTTCACAGGCGTTTCTGAAGGCACTGCAGGCACGCCATGGTGTACGCTTCGAGGCCAACAGCCGCTTCTCCGGC
GATGGGCGGGTGTTTCGGGTGCGCTACGCGCCGGGCAAGGGCGCCGAGGTAGGCGCGCTGTTGTCGCAGCTGGTGCAAAG
CGACGTGGCCGAGTACGCCGAGCCCAACTACGTCTACCGCACCCTCGGTTTTCCGAACGACCCGCTCTATCCAAAGCAGT
GGAATCTGCGCGCCATCGGCATCGAGAGCGCTTGGCAAAAGGCGGACGGTAGCGGGGCTGTGGTCGCAGTCATCGACACC
GGCGTGGCCCGCAGGCTGCCGGATATGGCCCAGACCGACTTTGTGCTCGGCTACGACTTTGTCAACGACGACGACGACGC
CACCGACGATCAGGGGCACGGCTCCCACGTCGCGGGCACCATCGCCCAATCGACCGACAACGGCGAAGGGGTGGCGGGGA
TCGCCTACCGGGCGCGGATCATGCCCGTCAAGGTGCTCGATCGCTACGGGTCCGGGTCCGCCCTCGACGTGGCCGAGGGC
ATCAAGTTTGCCGCCGACAACGGCGCCAATGTGATCAACCTCAGCCTCGGCGGCCCCGGCGACAGCTCGGTGTTGCGCGA
GGCGGTCGATTATGCCCACCGCAAGGGTGTGGTGGTCGTCTGCGCCGCCGGCAACGAAAGCGCTCCCCAGGCATCCTACC
CGGCTCTGTACGCCAACTGCCTGAGTGTCTCGGCCACCGGCCCGGACGGATCGCTGTCATTTTTCTCGAACTTCGGGCGC
GGCGTGGATCTGAGCGCTCCCGGCGGTGACAAGAGTGCTCTGGGAGCCGACGGCGGCATCTTGCAAAACACCATCGACGA
CCAGGGCAATTCTACCTACGCGAGCTACCAGGGCACCTCGATGGCTGCTCCCCACGTGGCCGGAGTGGCGGCCCTCGTCT
ATAGTGCCGGGGTGCAGGACGCGGCTGAAATTCGCAAGGTGCTGCTCAGTGCCACCCGTCCGGTGGGCCACGACTTTCAA
AACCAGCACGGTGCCGGGCAACTGAACGCCCAACTTGCCCTCGACAGCCTCGAAAACCCTTATTGGTTCTTCCGGGGAGG
CTTCTGGTGGTTGGTGCCGCTGGCCACCCTCGCCGTTGGTATTGTGCTGGGGGCGTTGGTGATGCTGGGCAGCCGCGCTA
TCGGTTTTAGCGAATTTTTCTACGCCATCGGCTTTGCAGCCACGGGACTCGGCTTCTTTCCGCTGTCGGCCTTCGGCACG
CTCTGGGGACCGGAAGGGCTACTGGCTCTACTTGCCACGCCGATCCCGAATTGGGATTTGCGCTTTTTTGAAGGCTGGCT
CAATCCCGGCCTGCACACGGTCCTGGTGCCGGGACTTGTTGCGGCGCTGTTTTCGGGTTCCGGCTGGGGACGCTCGCTGG
CCGTAGGGGCGTGCGTCGGCAGCGCAGCCCTCCTGGCTCTGCAGGGAAGCGTTTTTTATACGCCTTTGACATGGTTTACC
GAAGAGTCCTACGCCCGCGGCTTCTTGCTGGTCAACGCCTTACTCAGCCTGCTTTTGGGCTTTTTCGTCCACCGCAGCGG
CGTAGAGAACCCATGA

Upstream 100 bases:

>100_bases
TCCGCCAGGCAATCCCGCCGCTGGAGCCCGCCGGGTCCGCTGGCCACTTCAGGGTACCGCGATCTGCGTCGATTGGCTCA
CCCGCCGCCGCCCTAAGCGC

Downstream 100 bases:

>100_bases
ATCGGCTCGGGGCATTGGTAGGTCTGGGACTGGCGTTGCCGTTGCTGGTGCCCACAGCCGCCTGCCAGGCCCAAGTACGC
AAGGAGACCAGCATGTTTAC

Product: serine proteinase

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MLSSGQSLRPRVVAMRLRKWWTALLGWMALALAGTAALAEPMTLPQEAVIAFRDPVSQAFLKALQARHGVRFEANSRFSG
DGRVFRVRYAPGKGAEVGALLSQLVQSDVAEYAEPNYVYRTLGFPNDPLYPKQWNLRAIGIESAWQKADGSGAVVAVIDT
GVARRLPDMAQTDFVLGYDFVNDDDDATDDQGHGSHVAGTIAQSTDNGEGVAGIAYRARIMPVKVLDRYGSGSALDVAEG
IKFAADNGANVINLSLGGPGDSSVLREAVDYAHRKGVVVVCAAGNESAPQASYPALYANCLSVSATGPDGSLSFFSNFGR
GVDLSAPGGDKSALGADGGILQNTIDDQGNSTYASYQGTSMAAPHVAGVAALVYSAGVQDAAEIRKVLLSATRPVGHDFQ
NQHGAGQLNAQLALDSLENPYWFFRGGFWWLVPLATLAVGIVLGALVMLGSRAIGFSEFFYAIGFAATGLGFFPLSAFGT
LWGPEGLLALLATPIPNWDLRFFEGWLNPGLHTVLVPGLVAALFSGSGWGRSLAVGACVGSAALLALQGSVFYTPLTWFT
EESYARGFLLVNALLSLLLGFFVHRSGVENP

Sequences:

>Translated_591_residues
MLSSGQSLRPRVVAMRLRKWWTALLGWMALALAGTAALAEPMTLPQEAVIAFRDPVSQAFLKALQARHGVRFEANSRFSG
DGRVFRVRYAPGKGAEVGALLSQLVQSDVAEYAEPNYVYRTLGFPNDPLYPKQWNLRAIGIESAWQKADGSGAVVAVIDT
GVARRLPDMAQTDFVLGYDFVNDDDDATDDQGHGSHVAGTIAQSTDNGEGVAGIAYRARIMPVKVLDRYGSGSALDVAEG
IKFAADNGANVINLSLGGPGDSSVLREAVDYAHRKGVVVVCAAGNESAPQASYPALYANCLSVSATGPDGSLSFFSNFGR
GVDLSAPGGDKSALGADGGILQNTIDDQGNSTYASYQGTSMAAPHVAGVAALVYSAGVQDAAEIRKVLLSATRPVGHDFQ
NQHGAGQLNAQLALDSLENPYWFFRGGFWWLVPLATLAVGIVLGALVMLGSRAIGFSEFFYAIGFAATGLGFFPLSAFGT
LWGPEGLLALLATPIPNWDLRFFEGWLNPGLHTVLVPGLVAALFSGSGWGRSLAVGACVGSAALLALQGSVFYTPLTWFT
EESYARGFLLVNALLSLLLGFFVHRSGVENP
>Mature_591_residues
MLSSGQSLRPRVVAMRLRKWWTALLGWMALALAGTAALAEPMTLPQEAVIAFRDPVSQAFLKALQARHGVRFEANSRFSG
DGRVFRVRYAPGKGAEVGALLSQLVQSDVAEYAEPNYVYRTLGFPNDPLYPKQWNLRAIGIESAWQKADGSGAVVAVIDT
GVARRLPDMAQTDFVLGYDFVNDDDDATDDQGHGSHVAGTIAQSTDNGEGVAGIAYRARIMPVKVLDRYGSGSALDVAEG
IKFAADNGANVINLSLGGPGDSSVLREAVDYAHRKGVVVVCAAGNESAPQASYPALYANCLSVSATGPDGSLSFFSNFGR
GVDLSAPGGDKSALGADGGILQNTIDDQGNSTYASYQGTSMAAPHVAGVAALVYSAGVQDAAEIRKVLLSATRPVGHDFQ
NQHGAGQLNAQLALDSLENPYWFFRGGFWWLVPLATLAVGIVLGALVMLGSRAIGFSEFFYAIGFAATGLGFFPLSAFGT
LWGPEGLLALLATPIPNWDLRFFEGWLNPGLHTVLVPGLVAALFSGSGWGRSLAVGACVGSAALLALQGSVFYTPLTWFT
EESYARGFLLVNALLSLLLGFFVHRSGVENP

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI27894285, Length=340, Percent_Identity=26.1764705882353, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI20336186, Length=352, Percent_Identity=26.4204545454545, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI20336190, Length=340, Percent_Identity=26.1764705882353, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI20336188, Length=340, Percent_Identity=26.1764705882353, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI20336180, Length=340, Percent_Identity=26.1764705882353, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI20336184, Length=340, Percent_Identity=26.1764705882353, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI20336182, Length=311, Percent_Identity=27.0096463022508, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4505577, Length=311, Percent_Identity=27.0096463022508, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI76443679, Length=351, Percent_Identity=26.4957264957265, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI299523015, Length=325, Percent_Identity=26.7692307692308, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4505579, Length=351, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI20336246, Length=327, Percent_Identity=26.2996941896024, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71983555, Length=310, Percent_Identity=25.1612903225806, Blast_Score=66, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=245, Percent_Identity=33.8775510204082, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324576, Length=251, Percent_Identity=32.2709163346614, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319893, Length=282, Percent_Identity=30.1418439716312, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360987, Length=359, Percent_Identity=26.7409470752089, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24642494, Length=321, Percent_Identity=27.4143302180685, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24642490, Length=321, Percent_Identity=27.4143302180685, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45555723, Length=321, Percent_Identity=27.4143302180685, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24642492, Length=321, Percent_Identity=27.4143302180685, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 62352; Mature: 62352

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSGQSLRPRVVAMRLRKWWTALLGWMALALAGTAALAEPMTLPQEAVIAFRDPVSQAF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHH
LKALQARHGVRFEANSRFSGDGRVFRVRYAPGKGAEVGALLSQLVQSDVAEYAEPNYVYR
HHHHHHHCCCEEECCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
TLGFPNDPLYPKQWNLRAIGIESAWQKADGSGAVVAVIDTGVARRLPDMAQTDFVLGYDF
ECCCCCCCCCCCCCCEEEEECHHHHHCCCCCCCEEEEECCCHHHHCCCHHHCCEEEEEEC
VNDDDDATDDQGHGSHVAGTIAQSTDNGEGVAGIAYRARIMPVKVLDRYGSGSALDVAEG
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEHHHHEEECCHHHHHCCCCCCCEEHHHC
IKFAADNGANVINLSLGGPGDSSVLREAVDYAHRKGVVVVCAAGNESAPQASYPALYANC
CEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHH
LSVSATGPDGSLSFFSNFGRGVDLSAPGGDKSALGADGGILQNTIDDQGNSTYASYQGTS
HEEECCCCCCCHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCC
MAAPHVAGVAALVYSAGVQDAAEIRKVLLSATRPVGHDFQNQHGAGQLNAQLALDSLENP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHEEEHHCCCCC
YWFFRGGFWWLVPLATLAVGIVLGALVMLGSRAIGFSEFFYAIGFAATGLGFFPLSAFGT
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
LWGPEGLLALLATPIPNWDLRFFEGWLNPGLHTVLVPGLVAALFSGSGWGRSLAVGACVG
HCCHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SAALLALQGSVFYTPLTWFTEESYARGFLLVNALLSLLLGFFVHRSGVENP
HHHHHHCCCCEEEECHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLSSGQSLRPRVVAMRLRKWWTALLGWMALALAGTAALAEPMTLPQEAVIAFRDPVSQAF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHH
LKALQARHGVRFEANSRFSGDGRVFRVRYAPGKGAEVGALLSQLVQSDVAEYAEPNYVYR
HHHHHHHCCCEEECCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
TLGFPNDPLYPKQWNLRAIGIESAWQKADGSGAVVAVIDTGVARRLPDMAQTDFVLGYDF
ECCCCCCCCCCCCCCEEEEECHHHHHCCCCCCCEEEEECCCHHHHCCCHHHCCEEEEEEC
VNDDDDATDDQGHGSHVAGTIAQSTDNGEGVAGIAYRARIMPVKVLDRYGSGSALDVAEG
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEHHHHEEECCHHHHHCCCCCCCEEHHHC
IKFAADNGANVINLSLGGPGDSSVLREAVDYAHRKGVVVVCAAGNESAPQASYPALYANC
CEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHH
LSVSATGPDGSLSFFSNFGRGVDLSAPGGDKSALGADGGILQNTIDDQGNSTYASYQGTS
HEEECCCCCCCHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCC
MAAPHVAGVAALVYSAGVQDAAEIRKVLLSATRPVGHDFQNQHGAGQLNAQLALDSLENP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHEEEHHCCCCC
YWFFRGGFWWLVPLATLAVGIVLGALVMLGSRAIGFSEFFYAIGFAATGLGFFPLSAFGT
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
LWGPEGLLALLATPIPNWDLRFFEGWLNPGLHTVLVPGLVAALFSGSGWGRSLAVGACVG
HCCHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SAALLALQGSVFYTPLTWFTEESYARGFLLVNALLSLLLGFFVHRSGVENP
HHHHHHCCCCEEEECHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]