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The map label for this gene is coaBC [H]

Identifier: 37521117

GI number: 37521117

Start: 1668372

End: 1669580

Strand: Direct

Name: coaBC [H]

Synonym: glr1548

Alternate gene names: 37521117

Gene position: 1668372-1669580 (Clockwise)

Preceding gene: 37521116

Following gene: 37521118

Centisome position: 35.81

GC content: 66.75

Gene sequence:

>1209_bases
ATGTTCGCGGGTCGGCGCGTCCTGGTGGCCGTCACCGGCGGCATCGCCGCCTACAAAGTCTGCGAGGTGGTCTCCACCCT
CGCCCAGGCGGGCGCCTCCGTGCGCGTGCTGCTCACGGAGGCGGCCGAACGGTTTGTAAGCGCCCTCACCTTCGCCACCC
TGGCGCGGGCGCGCGCTTACACCGACGCCGACTTTTGGTCGGCGGAGCACGGCGCGCCCCTGCACATCGCCCTGGGCCAG
TGGGCCGAGGTGATCTTGATCGCACCCGTCACCGCCCACACCCTGGCGCGACTGGCCCTGGGGCTCGCCGACGACCTGCT
CACCAACACGGTGCTCGCTTCGAGCGCCCCGATTTTGCTTGCCCCGGCGATGAACACCCAGATGTGGGAACAGGAGCCGG
TCGCAGCGCATGCGCAGACGCTGATTACCCGGCCGCGCTACCACCTGAGCGGTCCTGGCCGGGGGCGGCTTGCCTGCGAC
GCGGTGGGAGCCGGGCGCCTCAGCGAACCGGCGGTGCTTTTGCGCCACCTCGGTTCGCTTCTTTGGAGCGGCGGCAAACA
GGATCTGGCGGGCAAAACCGTGCTGGTCACCGGCGGCGGCACCCGCGAGTTTCTCGACCCGGTGCGTTTTATCGGCAACC
CCAGCAGCGGCCGGATGGGTATTGAGCTGGCCGCCGCCTGCGCCCACCGCGGCGGGACGGTGCACTTGGTGCTGGGTCCG
ACGCACCTGGAGGCCCCCCCGGAGGTCGATTGCCACCCGGTGGTCGGCGCCGCCCAGATGGCCCAGGCCACTTTTGCGCT
GTTCGAGCGGGCACATTTGACATTCATGGCCGCGGCGGTGGCCGATGTACGCCCAAGCCAAATCCACATCGACAAAATTC
CCAAAAACCAGCTGGGCAATAGGCTCACCCTGGAGCCGGTCGAGGATATTTTGCTCGAACTTTCTCGCCGTAAGCAACCC
TGGCAAACACTGGTCGGTTTTGCCGCCCAGACCGGCGAGGACTGGTTGGTTCCCGCGGCGGCCAAGCTCAAAGCCAAACA
CCTCGATTGGCTGGTGGCCAACCGCGTCGACCTCCAAGAGCAGGGCTTCGGCGGTGACAACAATCAGGCTATGCTCTTAA
GCAGCCGCGGGGATATGCATGCGATTCCCCTGATGAGCAAACTGGAGATGGCCCACCGCCTGCTGGATCGAATGGAGACT
CCCGCGTGA

Upstream 100 bases:

>100_bases
TCTCAGCCTCGACACGCGCCAGGACGTCAACCAGGCCCTCGAAGAAATCGACGATCTGCTGGTGGAATTCGAACGCACCT
TCCCGGGCGGCTAGCGGGCG

Downstream 100 bases:

>100_bases
TCCGCACACCCTGGTTCGACGAGCAAACCGGCGAGTTGGCCTTCCAGGTGGTCAGCCGCGCAGACTCCTGGCAACTGGCC
CTCGCGGACGGGGTGGTTAC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MFAGRRVLVAVTGGIAAYKVCEVVSTLAQAGASVRVLLTEAAERFVSALTFATLARARAYTDADFWSAEHGAPLHIALGQ
WAEVILIAPVTAHTLARLALGLADDLLTNTVLASSAPILLAPAMNTQMWEQEPVAAHAQTLITRPRYHLSGPGRGRLACD
AVGAGRLSEPAVLLRHLGSLLWSGGKQDLAGKTVLVTGGGTREFLDPVRFIGNPSSGRMGIELAAACAHRGGTVHLVLGP
THLEAPPEVDCHPVVGAAQMAQATFALFERAHLTFMAAAVADVRPSQIHIDKIPKNQLGNRLTLEPVEDILLELSRRKQP
WQTLVGFAAQTGEDWLVPAAAKLKAKHLDWLVANRVDLQEQGFGGDNNQAMLLSSRGDMHAIPLMSKLEMAHRLLDRMET
PA

Sequences:

>Translated_402_residues
MFAGRRVLVAVTGGIAAYKVCEVVSTLAQAGASVRVLLTEAAERFVSALTFATLARARAYTDADFWSAEHGAPLHIALGQ
WAEVILIAPVTAHTLARLALGLADDLLTNTVLASSAPILLAPAMNTQMWEQEPVAAHAQTLITRPRYHLSGPGRGRLACD
AVGAGRLSEPAVLLRHLGSLLWSGGKQDLAGKTVLVTGGGTREFLDPVRFIGNPSSGRMGIELAAACAHRGGTVHLVLGP
THLEAPPEVDCHPVVGAAQMAQATFALFERAHLTFMAAAVADVRPSQIHIDKIPKNQLGNRLTLEPVEDILLELSRRKQP
WQTLVGFAAQTGEDWLVPAAAKLKAKHLDWLVANRVDLQEQGFGGDNNQAMLLSSRGDMHAIPLMSKLEMAHRLLDRMET
PA
>Mature_402_residues
MFAGRRVLVAVTGGIAAYKVCEVVSTLAQAGASVRVLLTEAAERFVSALTFATLARARAYTDADFWSAEHGAPLHIALGQ
WAEVILIAPVTAHTLARLALGLADDLLTNTVLASSAPILLAPAMNTQMWEQEPVAAHAQTLITRPRYHLSGPGRGRLACD
AVGAGRLSEPAVLLRHLGSLLWSGGKQDLAGKTVLVTGGGTREFLDPVRFIGNPSSGRMGIELAAACAHRGGTVHLVLGP
THLEAPPEVDCHPVVGAAQMAQATFALFERAHLTFMAAAVADVRPSQIHIDKIPKNQLGNRLTLEPVEDILLELSRRKQP
WQTLVGFAAQTGEDWLVPAAAKLKAKHLDWLVANRVDLQEQGFGGDNNQAMLLSSRGDMHAIPLMSKLEMAHRLLDRMET
PA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=34.9206349206349, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87082301, Length=408, Percent_Identity=37.2549019607843, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17560194, Length=186, Percent_Identity=33.8709677419355, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=180, Percent_Identity=30.5555555555556, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322925, Length=164, Percent_Identity=28.6585365853659, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324629, Length=138, Percent_Identity=29.7101449275362, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24657262, Length=178, Percent_Identity=30.8988764044944, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42979; Mature: 42979

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAGRRVLVAVTGGIAAYKVCEVVSTLAQAGASVRVLLTEAAERFVSALTFATLARARAY
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHC
TDADFWSAEHGAPLHIALGQWAEVILIAPVTAHTLARLALGLADDLLTNTVLASSAPILL
CCCHHCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNTQMWEQEPVAAHAQTLITRPRYHLSGPGRGRLACDAVGAGRLSEPAVLLRHLGSL
EECCCCHHHCCCCHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHH
LWSGGKQDLAGKTVLVTGGGTREFLDPVRFIGNPSSGRMGIELAAACAHRGGTVHLVLGP
HHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECC
THLEAPPEVDCHPVVGAAQMAQATFALFERAHLTFMAAAVADVRPSQIHIDKIPKNQLGN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCC
RLTLEPVEDILLELSRRKQPWQTLVGFAAQTGEDWLVPAAAKLKAKHLDWLVANRVDLQE
EEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
QGFGGDNNQAMLLSSRGDMHAIPLMSKLEMAHRLLDRMETPA
CCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFAGRRVLVAVTGGIAAYKVCEVVSTLAQAGASVRVLLTEAAERFVSALTFATLARARAY
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHC
TDADFWSAEHGAPLHIALGQWAEVILIAPVTAHTLARLALGLADDLLTNTVLASSAPILL
CCCHHCCCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNTQMWEQEPVAAHAQTLITRPRYHLSGPGRGRLACDAVGAGRLSEPAVLLRHLGSL
EECCCCHHHCCCCHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHH
LWSGGKQDLAGKTVLVTGGGTREFLDPVRFIGNPSSGRMGIELAAACAHRGGTVHLVLGP
HHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECC
THLEAPPEVDCHPVVGAAQMAQATFALFERAHLTFMAAAVADVRPSQIHIDKIPKNQLGN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCC
RLTLEPVEDILLELSRRKQPWQTLVGFAAQTGEDWLVPAAAKLKAKHLDWLVANRVDLQE
EEEECHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHH
QGFGGDNNQAMLLSSRGDMHAIPLMSKLEMAHRLLDRMETPA
CCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]