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The map label for this gene is pyrG

Identifier: 37521093

GI number: 37521093

Start: 1641821

End: 1643470

Strand: Direct

Name: pyrG

Synonym: gvip211

Alternate gene names: 37521093

Gene position: 1641821-1643470 (Clockwise)

Preceding gene: 37521092

Following gene: 37521094

Centisome position: 35.24

GC content: 63.21

Gene sequence:

>1650_bases
ATGACAAAGTATGTATTCGTAACGGGCGGTGTCGTGTCCTCGATCGGCAAAGGCATCGTCGCCGCTTCCCTAGGCCGTCT
GCTCAAATCGCGGGGCTACTCGGTGACGATCCTCAAGCTCGATCCGTACATCAACGTCGATCCGGGCACGATGAGCCCGT
TTCAGCACGGCGAGGTGTTCGTCACCAACGACGGCGCCGAGACCGACCTGGACCTGGGCCATTACGAGCGATTCACCGAT
ACCGACGTCTCCAAGCTCAACAACGTCACCACCGGCTCGATTTACCAGAGTGTGATCAACAAAGAACGCCGGGGCGACTA
CATGGGCGGCACGGTCCAGGTCATCCCCCACATCACCAACGAGATCAAAGAGCGCATCCGCCGGGTGGCCCACGACACCA
ACCCGGACGTGGTGATTGTCGAGGTGGGCGGCACCGTGGGCGATATCGAGTCGCTGCCGTTTCTGGAGGCGATCCGCCAG
TTTCGCAAGGACGTCGGCCGCGAGAACGTGCTCTATATTCACGTCACCTATATCCTGCACATCCCGACCGCGGGCGAGAT
GAAGACCAAGCCCACCCAGCACTCGGTCAAAGAATTGCGCTCGATCGGTATCCAGCCGGATATTCTGGTCTGCCGCTCCG
ACCGGCCTCTCAGCGTCGGGATCAAAGACAAGATTTCTGAATTTTGCGATGTGCCGGTGCGGGCGGTGATCACCTGCCAG
GACGCCCAGACCATTTACGCCGTGCCCCTCAATCTGGAGCGCGAAGGGCTCGCCCATCAGGCGATCACGCTTTTGGGCCT
CGAGCAGCGCCAGCCGGACCTGCGCGATTGGGAAATTCTGGTCGACCGCATCTGCAACCCGTCGCGCGCGGTGACCATCG
CCATCGTCGGCAAGTACGTGCGGCTCTCGGACGCCTATATCTCGGTGGTCGAAGCGCTCAGGCACGCCGCGGTCGCCCTC
GACGCCGAAGTCAAAGTCGAATGGGTCTCAGCCGAAGCGGTCGAGGAGCGCGGAGCCGGTTATTTTCTGAACAACGTCGA
TGGGGCGGTGGTGCCGGGGGGCTTCGGTTCGCGCGGCATCGACGGCAAAGTGAGCGCTATCGAGTTTTCCCGCGGGCACC
GATTGCCCTTCTTGGGCCTGTGTCTCGGCATGCAGTGCTCGGTGATCGAGTGGGCGCGCCACACCGCCGGGCTTGCCGCC
AACAGCACCGAGTTCGACCCGCAGACCCCCAACCCGGTCATTTCACTGCTCCCCGAGCAGGCGGACGTGGTGGATCTAGG
CGGCACGATGCGCCTGGGGCTCTGGCCCTGCCGTCTGCAGGAAGGCACCCTGGCCCACCGCCTCTACGGCGAGACGCTGG
TCTACGAGCGTCACCGCCACCGCTACGAGTTCAACAACGCCTACCGCAAGGCGATTATCGAAGCGGGCTTCCAGATCAGC
GGCGCCTCCCCCGACGAGCGCCTCGTCGAAATCATCGAACTGGCCGATCACCCCTACTTCATCGCCACCCAGTTTCACCC
CGAGTTCAAGTCGCGGCCCAACAAACCCCACCCGCTCTTTTTCGGTCTGGTGCGCGCCGCCCTCGAGCGCAAGGAGACAG
AACGGCTACCCGCCAGTCCGGCACCGGTCCCGCTGCCGTCCGCGGTTTGA

Upstream 100 bases:

>100_bases
CCAAGATAGTTGTTGCAGTGCCATGTCCACACAGGCCGCAACGCTGCTGCGGCTCGCTTGCTATAATCAACCGAATTGGG
GTGTTCTGGGTGATGCCGGT

Downstream 100 bases:

>100_bases
CCGGATTGGCCGAATCGAAAATGCTCCAAGACTTGCCCTAGTGGCTGACCTTCAGCTAAGCTGCTTGCAACCCCTACATC
TAGAGTAGGGGAGCGCCTGG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTKYVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVTILKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFTD
TDVSKLNNVTTGSIYQSVINKERRGDYMGGTVQVIPHITNEIKERIRRVAHDTNPDVVIVEVGGTVGDIESLPFLEAIRQ
FRKDVGRENVLYIHVTYILHIPTAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLSVGIKDKISEFCDVPVRAVITCQ
DAQTIYAVPLNLEREGLAHQAITLLGLEQRQPDLRDWEILVDRICNPSRAVTIAIVGKYVRLSDAYISVVEALRHAAVAL
DAEVKVEWVSAEAVEERGAGYFLNNVDGAVVPGGFGSRGIDGKVSAIEFSRGHRLPFLGLCLGMQCSVIEWARHTAGLAA
NSTEFDPQTPNPVISLLPEQADVVDLGGTMRLGLWPCRLQEGTLAHRLYGETLVYERHRHRYEFNNAYRKAIIEAGFQIS
GASPDERLVEIIELADHPYFIATQFHPEFKSRPNKPHPLFFGLVRAALERKETERLPASPAPVPLPSAV

Sequences:

>Translated_549_residues
MTKYVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVTILKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFTD
TDVSKLNNVTTGSIYQSVINKERRGDYMGGTVQVIPHITNEIKERIRRVAHDTNPDVVIVEVGGTVGDIESLPFLEAIRQ
FRKDVGRENVLYIHVTYILHIPTAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLSVGIKDKISEFCDVPVRAVITCQ
DAQTIYAVPLNLEREGLAHQAITLLGLEQRQPDLRDWEILVDRICNPSRAVTIAIVGKYVRLSDAYISVVEALRHAAVAL
DAEVKVEWVSAEAVEERGAGYFLNNVDGAVVPGGFGSRGIDGKVSAIEFSRGHRLPFLGLCLGMQCSVIEWARHTAGLAA
NSTEFDPQTPNPVISLLPEQADVVDLGGTMRLGLWPCRLQEGTLAHRLYGETLVYERHRHRYEFNNAYRKAIIEAGFQIS
GASPDERLVEIIELADHPYFIATQFHPEFKSRPNKPHPLFFGLVRAALERKETERLPASPAPVPLPSAV
>Mature_548_residues
TKYVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVTILKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFTDT
DVSKLNNVTTGSIYQSVINKERRGDYMGGTVQVIPHITNEIKERIRRVAHDTNPDVVIVEVGGTVGDIESLPFLEAIRQF
RKDVGRENVLYIHVTYILHIPTAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLSVGIKDKISEFCDVPVRAVITCQD
AQTIYAVPLNLEREGLAHQAITLLGLEQRQPDLRDWEILVDRICNPSRAVTIAIVGKYVRLSDAYISVVEALRHAAVALD
AEVKVEWVSAEAVEERGAGYFLNNVDGAVVPGGFGSRGIDGKVSAIEFSRGHRLPFLGLCLGMQCSVIEWARHTAGLAAN
STEFDPQTPNPVISLLPEQADVVDLGGTMRLGLWPCRLQEGTLAHRLYGETLVYERHRHRYEFNNAYRKAIIEAGFQISG
ASPDERLVEIIELADHPYFIATQFHPEFKSRPNKPHPLFFGLVRAALERKETERLPASPAPVPLPSAV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=48, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=46.800731261426, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=46.800731261426, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=46.800731261426, Blast_Score=492, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=539, Percent_Identity=53.9888682745826, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25148299, Length=600, Percent_Identity=39.8333333333333, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322563, Length=560, Percent_Identity=45.1785714285714, Blast_Score=455, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=43.9068100358423, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24664469, Length=550, Percent_Identity=47.6363636363636, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=46.0606060606061, Blast_Score=425, Evalue=1e-119,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_GLOVI (Q7NKF4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924470.1
- HSSP:   P17812
- ProteinModelPortal:   Q7NKF4
- SMR:   Q7NKF4
- GeneID:   2598598
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1524
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   GVIO251221:GLR1524-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60696; Mature: 60565

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 381-381 ACT_SITE 506-506 ACT_SITE 508-508

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVTILKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTNDGAETDLDLGHYERFTDTDVSKLNNVTTGSIYQSVINKERRGDYMGGTVQVIPHITN
EECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
EIKERIRRVAHDTNPDVVIVEVGGTVGDIESLPFLEAIRQFRKDVGRENVLYIHVTYILH
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
IPTAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLSVGIKDKISEFCDVPVRAVITCQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEECCHHHHHHHHHCCCEEEEEEEC
DAQTIYAVPLNLEREGLAHQAITLLGLEQRQPDLRDWEILVDRICNPSRAVTIAIVGKYV
CCCEEEEEECCCCCCCHHHHHHHHHCCHHCCCCCHHHHHHHHHHCCCCCEEEEEEEECHH
RLSDAYISVVEALRHAAVALDAEVKVEWVSAEAVEERGAGYFLNNVDGAVVPGGFGSRGI
HHHHHHHHHHHHHHHHHHEECCEEEEEEEEHHHHHHCCCCEEEECCCCEEECCCCCCCCC
DGKVSAIEFSRGHRLPFLGLCLGMQCSVIEWARHTAGLAANSTEFDPQTPNPVISLLPEQ
CCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCC
ADVVDLGGTMRLGLWPCRLQEGTLAHRLYGETLVYERHRHRYEFNNAYRKAIIEAGFQIS
CCEEECCCEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEC
GASPDERLVEIIELADHPYFIATQFHPEFKSRPNKPHPLFFGLVRAALERKETERLPASP
CCCCHHHHHHHHHHCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
APVPLPSAV
CCCCCCCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVTILKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTNDGAETDLDLGHYERFTDTDVSKLNNVTTGSIYQSVINKERRGDYMGGTVQVIPHITN
EECCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
EIKERIRRVAHDTNPDVVIVEVGGTVGDIESLPFLEAIRQFRKDVGRENVLYIHVTYILH
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
IPTAGEMKTKPTQHSVKELRSIGIQPDILVCRSDRPLSVGIKDKISEFCDVPVRAVITCQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCEECCHHHHHHHHHCCCEEEEEEEC
DAQTIYAVPLNLEREGLAHQAITLLGLEQRQPDLRDWEILVDRICNPSRAVTIAIVGKYV
CCCEEEEEECCCCCCCHHHHHHHHHCCHHCCCCCHHHHHHHHHHCCCCCEEEEEEEECHH
RLSDAYISVVEALRHAAVALDAEVKVEWVSAEAVEERGAGYFLNNVDGAVVPGGFGSRGI
HHHHHHHHHHHHHHHHHHEECCEEEEEEEEHHHHHHCCCCEEEECCCCEEECCCCCCCCC
DGKVSAIEFSRGHRLPFLGLCLGMQCSVIEWARHTAGLAANSTEFDPQTPNPVISLLPEQ
CCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCC
ADVVDLGGTMRLGLWPCRLQEGTLAHRLYGETLVYERHRHRYEFNNAYRKAIIEAGFQIS
CCEEECCCEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEC
GASPDERLVEIIELADHPYFIATQFHPEFKSRPNKPHPLFFGLVRAALERKETERLPASP
CCCCHHHHHHHHHHCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
APVPLPSAV
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292