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The map label for this gene is ppiD [H]

Identifier: 34498008

GI number: 34498008

Start: 2745389

End: 2747227

Strand: Reverse

Name: ppiD [H]

Synonym: CV_2553

Alternate gene names: 34498008

Gene position: 2747227-2745389 (Counterclockwise)

Preceding gene: 34498009

Following gene: 34498006

Centisome position: 57.82

GC content: 64.93

Gene sequence:

>1839_bases
ATGTTCGAGTTTGTCCAGAACAACAAAACCGTCATTCAAGTGATCCTGGGCGCCGTGGCCCTGACTTTCGTGGGCTTCGG
CGTCGGCAGCTACTCCAGCGCCACCGACGATCCCTACCTGGTCAAGGTGGGCAAGACCAAGATCTACAAACGCGACCTGG
ATCGCGCGCTGGAAGGGCAGCCCAGCGATCCGGCAACCCGCCAGGCCGCGCTGGAGAACCTGATCCGCCAGGAGCTGCTG
CTGGCCGAGGCCCGCGACCACGGCGCCGCCGTCAGCCCCGATCAGTTGCGCAAGGCGATCGCCTCCATTCCCGCCTTTCA
GGAGAACGGCCAGTTCAGCGCCCAGCGCTACAGCGAGTTTCTGAAGAGCCGCTACCCGAATCCGGAAGCCTTCGAGGCCG
ACATCAGCCGCGACATCCTGCTGCAGAGCCAATTGAGCAGCGTGGCGGGCACCCAGTTCGTGTCCAATACCGTGGTGACC
CGCGTGGCGGGCCTGCTGGGCGAGGGCCGGGAGCTGCAGCCTCTGGTGCTCAAGCCGTCCGACTTCGCTTCCGAGGTGAA
GACCGACGCCGCCGCGATCAAGGCCTATTACGACGCCAACGCCAAGCGCTTCAGCCTGCCGGAGCAGGTGAAGCTGGACT
ACGTGGTGCTGTCGCAGGACGCGCTGGCCCAAGGCATCAAGGTCAGCGACGCCGAGGTGCAGAAGTACTACGACCAGCAC
AAGGCCGACCTGGCCGGCGAACAGCGCCGCGCGTCCCACATCCTGCTGACGGTGGCCAAGGATGCCAAGCCTGAACAAAA
GGCCAAGGTCAAGGCCGAGGCGGAGGCGATCCTGAAAGAGGTGCGCGTCAATCCGGCCAAGTTCGCCGAATTGGCCAAGG
CCAAGTCGCAGGATCCGGGCTCCGCCGAGAAGGGCGGCGATCTGGGCTTCTTCGGCCACGGCATGATGGTCAAGCCGTTC
GACGACGCGGTGTTCAAGATGAAGCCGGGCCAGATCAGCGACCTGGTGGAAACCGAGTACGGCTTTCATATCATCCGCCT
GGACGCGGTCAAGTCGCAGAGCCTGGACGACGTCAAGGGCGCGGTCGTCGACAAGCTGCAGAAGCAGAAAGCCGCGGCGC
TGTTCCACGAGCAGGCCGGCAAACTGAACGAAATCGCCTACCAGCAGGCCGATTCGTTGAAAGGCGTGGTCGACGCGTTG
AAGCTTGAGGTCAAACATTCCGACTGGGTCCGGCGCAACCAGCCGTCGCAAGACGAGCTGCTGGGCAACGCCAAACTGCT
GTCCGCCGTATTCAGCGACGATGTGCTGAAGAAAAAGCACAACAGCGAAGTGGTGGATATCGGCGGCAACCGCCTGGTGG
TCGCCCGCATCGCCGAGCATCAGCCGGAGCGCCAGCAGCCGTTGGCCGATGTCACGGACGCGATCCGCAAGGAACTGGTG
GAGCGCGACGGCGCCAAGCTGGCGGACAAGAAGGGGCAGGCGCTGTTGGCTGAGCTGAAGGCCGGCAAGGGCGTGGACGC
GCAGAAGTGGGGCCCCGCCGCCACCGTTTCCCGCCGCGCCGCTGCCGGCATGCCCGCCGCCGACGTGCGCGCGGTGTTCG
CCGTGGCCGGCAGCAAGCTGCCTGGCTTCGCCGGCGTGCGCCATGATACCGGCGAGTACGTGATCTACCGAGTCAACAAG
GTGATTCCGGCGCCGGCCGTCACCGATGCCGACAAGGCTCAGTTGGGCAATGTGCTGGGCGAGTTGAGCGCCAACAGCCA
GCTGGCCAGCTACCTGAAGGCGCTGCGCGAGAAGTACCCGGTCACCGCCGGCAAGCAATCGCTGACCGACAGCAACTGA

Upstream 100 bases:

>100_bases
CGCGGGTTCGAGCCCCGTCCACTCCGCCAAATACACGAGAGAAGGTGAACCGTTTGCGCGTTCACCTTTTTTTTTACAGG
GGTGGCCTTAGCCAATCGTC

Downstream 100 bases:

>100_bases
TCCGGCTCCGTCCCGGCTCCAGCCCCGCGCATGCGGGGCTTTTTGCTTTCAGCCCGGCGCATGGCGGCCGAAGCCGCGCG
CCTGGGCTTCCAGGCGCAGC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MFEFVQNNKTVIQVILGAVALTFVGFGVGSYSSATDDPYLVKVGKTKIYKRDLDRALEGQPSDPATRQAALENLIRQELL
LAEARDHGAAVSPDQLRKAIASIPAFQENGQFSAQRYSEFLKSRYPNPEAFEADISRDILLQSQLSSVAGTQFVSNTVVT
RVAGLLGEGRELQPLVLKPSDFASEVKTDAAAIKAYYDANAKRFSLPEQVKLDYVVLSQDALAQGIKVSDAEVQKYYDQH
KADLAGEQRRASHILLTVAKDAKPEQKAKVKAEAEAILKEVRVNPAKFAELAKAKSQDPGSAEKGGDLGFFGHGMMVKPF
DDAVFKMKPGQISDLVETEYGFHIIRLDAVKSQSLDDVKGAVVDKLQKQKAAALFHEQAGKLNEIAYQQADSLKGVVDAL
KLEVKHSDWVRRNQPSQDELLGNAKLLSAVFSDDVLKKKHNSEVVDIGGNRLVVARIAEHQPERQQPLADVTDAIRKELV
ERDGAKLADKKGQALLAELKAGKGVDAQKWGPAATVSRRAAAGMPAADVRAVFAVAGSKLPGFAGVRHDTGEYVIYRVNK
VIPAPAVTDADKAQLGNVLGELSANSQLASYLKALREKYPVTAGKQSLTDSN

Sequences:

>Translated_612_residues
MFEFVQNNKTVIQVILGAVALTFVGFGVGSYSSATDDPYLVKVGKTKIYKRDLDRALEGQPSDPATRQAALENLIRQELL
LAEARDHGAAVSPDQLRKAIASIPAFQENGQFSAQRYSEFLKSRYPNPEAFEADISRDILLQSQLSSVAGTQFVSNTVVT
RVAGLLGEGRELQPLVLKPSDFASEVKTDAAAIKAYYDANAKRFSLPEQVKLDYVVLSQDALAQGIKVSDAEVQKYYDQH
KADLAGEQRRASHILLTVAKDAKPEQKAKVKAEAEAILKEVRVNPAKFAELAKAKSQDPGSAEKGGDLGFFGHGMMVKPF
DDAVFKMKPGQISDLVETEYGFHIIRLDAVKSQSLDDVKGAVVDKLQKQKAAALFHEQAGKLNEIAYQQADSLKGVVDAL
KLEVKHSDWVRRNQPSQDELLGNAKLLSAVFSDDVLKKKHNSEVVDIGGNRLVVARIAEHQPERQQPLADVTDAIRKELV
ERDGAKLADKKGQALLAELKAGKGVDAQKWGPAATVSRRAAAGMPAADVRAVFAVAGSKLPGFAGVRHDTGEYVIYRVNK
VIPAPAVTDADKAQLGNVLGELSANSQLASYLKALREKYPVTAGKQSLTDSN
>Mature_612_residues
MFEFVQNNKTVIQVILGAVALTFVGFGVGSYSSATDDPYLVKVGKTKIYKRDLDRALEGQPSDPATRQAALENLIRQELL
LAEARDHGAAVSPDQLRKAIASIPAFQENGQFSAQRYSEFLKSRYPNPEAFEADISRDILLQSQLSSVAGTQFVSNTVVT
RVAGLLGEGRELQPLVLKPSDFASEVKTDAAAIKAYYDANAKRFSLPEQVKLDYVVLSQDALAQGIKVSDAEVQKYYDQH
KADLAGEQRRASHILLTVAKDAKPEQKAKVKAEAEAILKEVRVNPAKFAELAKAKSQDPGSAEKGGDLGFFGHGMMVKPF
DDAVFKMKPGQISDLVETEYGFHIIRLDAVKSQSLDDVKGAVVDKLQKQKAAALFHEQAGKLNEIAYQQADSLKGVVDAL
KLEVKHSDWVRRNQPSQDELLGNAKLLSAVFSDDVLKKKHNSEVVDIGGNRLVVARIAEHQPERQQPLADVTDAIRKELV
ERDGAKLADKKGQALLAELKAGKGVDAQKWGPAATVSRRAAAGMPAADVRAVFAVAGSKLPGFAGVRHDTGEYVIYRVNK
VIPAPAVTDADKAQLGNVLGELSANSQLASYLKALREKYPVTAGKQSLTDSN

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=544, Percent_Identity=29.9632352941176, Blast_Score=205, Evalue=7e-54,
Organism=Escherichia coli, GI1786238, Length=360, Percent_Identity=26.3888888888889, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 66364; Mature: 66364

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEFVQNNKTVIQVILGAVALTFVGFGVGSYSSATDDPYLVKVGKTKIYKRDLDRALEGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCC
PSDPATRQAALENLIRQELLLAEARDHGAAVSPDQLRKAIASIPAFQENGQFSAQRYSEF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LKSRYPNPEAFEADISRDILLQSQLSSVAGTQFVSNTVVTRVAGLLGEGRELQPLVLKPS
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCC
DFASEVKTDAAAIKAYYDANAKRFSLPEQVKLDYVVLSQDALAQGIKVSDAEVQKYYDQH
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCHHHHCCCCCCHHHHHHHHHHH
KADLAGEQRRASHILLTVAKDAKPEQKAKVKAEAEAILKEVRVNPAKFAELAKAKSQDPG
HHHHCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
SAEKGGDLGFFGHGMMVKPFDDAVFKMKPGQISDLVETEYGFHIIRLDAVKSQSLDDVKG
CCCCCCCCCEECCCCEECCCCCCCEEECCCCHHHHHHHCCCEEEEEEECCCCCCHHHHHH
AVVDKLQKQKAAALFHEQAGKLNEIAYQQADSLKGVVDALKLEVKHSDWVRRNQPSQDEL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
LGNAKLLSAVFSDDVLKKKHNSEVVDIGGNRLVVARIAEHQPERQQPLADVTDAIRKELV
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHH
ERDGAKLADKKGQALLAELKAGKGVDAQKWGPAATVSRRAAAGMPAADVRAVFAVAGSKL
HHCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
PGFAGVRHDTGEYVIYRVNKVIPAPAVTDADKAQLGNVLGELSANSQLASYLKALREKYP
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
VTAGKQSLTDSN
CCCCCCCCCCCC
>Mature Secondary Structure
MFEFVQNNKTVIQVILGAVALTFVGFGVGSYSSATDDPYLVKVGKTKIYKRDLDRALEGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCC
PSDPATRQAALENLIRQELLLAEARDHGAAVSPDQLRKAIASIPAFQENGQFSAQRYSEF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LKSRYPNPEAFEADISRDILLQSQLSSVAGTQFVSNTVVTRVAGLLGEGRELQPLVLKPS
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCC
DFASEVKTDAAAIKAYYDANAKRFSLPEQVKLDYVVLSQDALAQGIKVSDAEVQKYYDQH
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEECCHHHHCCCCCCHHHHHHHHHHH
KADLAGEQRRASHILLTVAKDAKPEQKAKVKAEAEAILKEVRVNPAKFAELAKAKSQDPG
HHHHCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
SAEKGGDLGFFGHGMMVKPFDDAVFKMKPGQISDLVETEYGFHIIRLDAVKSQSLDDVKG
CCCCCCCCCEECCCCEECCCCCCCEEECCCCHHHHHHHCCCEEEEEEECCCCCCHHHHHH
AVVDKLQKQKAAALFHEQAGKLNEIAYQQADSLKGVVDALKLEVKHSDWVRRNQPSQDEL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHH
LGNAKLLSAVFSDDVLKKKHNSEVVDIGGNRLVVARIAEHQPERQQPLADVTDAIRKELV
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHH
ERDGAKLADKKGQALLAELKAGKGVDAQKWGPAATVSRRAAAGMPAADVRAVFAVAGSKL
HHCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
PGFAGVRHDTGEYVIYRVNKVIPAPAVTDADKAQLGNVLGELSANSQLASYLKALREKYP
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
VTAGKQSLTDSN
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]