Click here to switch to the map view.

The map label for this gene is betA [C]

Identifier: 34497944

GI number: 34497944

Start: 2679222

End: 2680772

Strand: Reverse

Name: betA [C]

Synonym: CV_2489

Alternate gene names: 34497944

Gene position: 2680772-2679222 (Counterclockwise)

Preceding gene: 34497945

Following gene: 34497942

Centisome position: 56.42

GC content: 68.34

Gene sequence:

>1551_bases
ATGGATGGGGCGAAGCAAGACAAGGACCTGTCCTTGGCGGCGGATGTCGTCATTGTGGGCAGCGGCGCCGGCGGCGGCAT
CGCGGCCGAGGTGCTGAGCCGGGCCGGCCTCGACGTGCTGTTGCTGGAGGAGGGCGGGTTGTACAGCTCCAGCGATTTCC
GGCTGCTGGAGGCCAAGGCCTATCCGGAGTTGTACCAGGAATCCGCCAGCCGGCAGACGCTGGACAAGGGCATCACCATC
CTGCAGGGCCGCGCGGTGGGCGGCGGCACCACGGTCAACTGGACCAGCAGTTTCCGCACGCCGGCGGACACGCTGTTGTG
GTGGCAGGAAAACCATGGGCTGGCCGGACTCAGCGCCGAAACCATGCGCCCCTGGTTTGAAAAGGCCGAGCAGCGGCTGG
GGATAGGACCGTGGCAGGCCGAGCCCAACGGCAACAACCTGGTGCTGGAGCGCGGCTGCCAGGCGCTGGGCCTGCGGCAC
GCGCGCATCGCGCGCAATGTGCGCGGCTGCTGGAATCTCGGCTACTGCGGCATGGGTTGCCCCACCAACGCCAAGCAGTC
AATGCTGGTCACCTGCATTCCGGAGGCGTTGTCCCATGGCGCCCGGCTGTTGAGCCGGGCCCGCGTCGAGCGGCTGCTGG
CCGACTCGGGCGGCGCAAGCATCGCGTCCGTTCAGGGAAGTTTGCTCGGCGCCGACGGCAATACGCCGACCGGGCTCCGC
TTCAGCGTCCGGGCGCGGCAGGTGGTGCTGGCGGCGGGCGCCATTGGCACGCCTGCCATCATGCTGCGCAGCGGCCTGCC
TGACGCGGGCGGCCAAACCGGCAAGCGCACCTTTCTGCATCCGGTGGCGCTGAGCGCCGCGCTGATGCCGGAAATGGTGG
AGCCTTACAATGGCGCGCCGCAAACCGTCTATTCCGACCACTACATGCATACGCAGTCGCTGGATGGCCCGCTGGGCTTC
AAGCTGGAGGTGCCCCCCATGCATCCCTTGCTTGCCAGCGTCACTTTCCCGGGTTTCGGCATCGAGCAATCGCAGCTGTT
GCAGCAGCTGCCGCATCTGCATGCCACGCTGGCCTTGCTGCGGGACGGCTTCCATCCGGACAGCCAGGGCGGGGCGGTGA
AGCTGCGCGGCGACGGTTCGCCCGCGCTGGACTACCCGCTCAACGACGTGGTCTGGGACGGCGTGCGGCGCAGCTGGCTG
GCGATGGCGGAGCTGCAGTTCGCGGCCGGCGCCAGCCTGGTGATGCCTTTGCATGAGCGCGCGCAGCCGATGTCGAGTTG
GAAACAGACCCGGGAGATGATAGCAGCGCTGCCCTTGCAGGCGCTGCAGGCCCGGCTGGTGAGCGCCCACGTGATGGGCG
GCATGGCGATGGGCGACGATCCCGCCCGCTCGGTGCTGGACGGCTGGGGCAGGCATTGGACGTGGCGCAATCTCACCGTG
GTGGATGGCTCCGCGTTTCCGACCAGCATAGGCGCCAATCCCCAGCTGTCGATCTACGCTTTCGCTTGGCGCGCGGCCGA
GCGGCTGGCCGAGGAAATGGCGAAAGCGTGA

Upstream 100 bases:

>100_bases
CATTGGGTTATAACCAGCCGGCGGCGGTGATGGGGATGCTGCCTTGAGCGGAAAGATACCCGATCCGATCCGGGCAGGTT
TGGCCAGCGGCTGGAAGGCG

Downstream 100 bases:

>100_bases
GGCCGGCAGGCGGCATTCGCCCGCCGGATGCGCTCAGTTTCGCGTTTCGTCCGCGGGGGGCGCGTCGACGGCGGTCGCCG
GCTCAGGCGGCGGGGGCAGG

Product: glucose-methanol-choline oxidoreductase

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MDGAKQDKDLSLAADVVIVGSGAGGGIAAEVLSRAGLDVLLLEEGGLYSSSDFRLLEAKAYPELYQESASRQTLDKGITI
LQGRAVGGGTTVNWTSSFRTPADTLLWWQENHGLAGLSAETMRPWFEKAEQRLGIGPWQAEPNGNNLVLERGCQALGLRH
ARIARNVRGCWNLGYCGMGCPTNAKQSMLVTCIPEALSHGARLLSRARVERLLADSGGASIASVQGSLLGADGNTPTGLR
FSVRARQVVLAAGAIGTPAIMLRSGLPDAGGQTGKRTFLHPVALSAALMPEMVEPYNGAPQTVYSDHYMHTQSLDGPLGF
KLEVPPMHPLLASVTFPGFGIEQSQLLQQLPHLHATLALLRDGFHPDSQGGAVKLRGDGSPALDYPLNDVVWDGVRRSWL
AMAELQFAAGASLVMPLHERAQPMSSWKQTREMIAALPLQALQARLVSAHVMGGMAMGDDPARSVLDGWGRHWTWRNLTV
VDGSAFPTSIGANPQLSIYAFAWRAAERLAEEMAKA

Sequences:

>Translated_516_residues
MDGAKQDKDLSLAADVVIVGSGAGGGIAAEVLSRAGLDVLLLEEGGLYSSSDFRLLEAKAYPELYQESASRQTLDKGITI
LQGRAVGGGTTVNWTSSFRTPADTLLWWQENHGLAGLSAETMRPWFEKAEQRLGIGPWQAEPNGNNLVLERGCQALGLRH
ARIARNVRGCWNLGYCGMGCPTNAKQSMLVTCIPEALSHGARLLSRARVERLLADSGGASIASVQGSLLGADGNTPTGLR
FSVRARQVVLAAGAIGTPAIMLRSGLPDAGGQTGKRTFLHPVALSAALMPEMVEPYNGAPQTVYSDHYMHTQSLDGPLGF
KLEVPPMHPLLASVTFPGFGIEQSQLLQQLPHLHATLALLRDGFHPDSQGGAVKLRGDGSPALDYPLNDVVWDGVRRSWL
AMAELQFAAGASLVMPLHERAQPMSSWKQTREMIAALPLQALQARLVSAHVMGGMAMGDDPARSVLDGWGRHWTWRNLTV
VDGSAFPTSIGANPQLSIYAFAWRAAERLAEEMAKA
>Mature_516_residues
MDGAKQDKDLSLAADVVIVGSGAGGGIAAEVLSRAGLDVLLLEEGGLYSSSDFRLLEAKAYPELYQESASRQTLDKGITI
LQGRAVGGGTTVNWTSSFRTPADTLLWWQENHGLAGLSAETMRPWFEKAEQRLGIGPWQAEPNGNNLVLERGCQALGLRH
ARIARNVRGCWNLGYCGMGCPTNAKQSMLVTCIPEALSHGARLLSRARVERLLADSGGASIASVQGSLLGADGNTPTGLR
FSVRARQVVLAAGAIGTPAIMLRSGLPDAGGQTGKRTFLHPVALSAALMPEMVEPYNGAPQTVYSDHYMHTQSLDGPLGF
KLEVPPMHPLLASVTFPGFGIEQSQLLQQLPHLHATLALLRDGFHPDSQGGAVKLRGDGSPALDYPLNDVVWDGVRRSWL
AMAELQFAAGASLVMPLHERAQPMSSWKQTREMIAALPLQALQARLVSAHVMGGMAMGDDPARSVLDGWGRHWTWRNLTV
VDGSAFPTSIGANPQLSIYAFAWRAAERLAEEMAKA

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 55191; Mature: 55191

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGAKQDKDLSLAADVVIVGSGAGGGIAAEVLSRAGLDVLLLEEGGLYSSSDFRLLEAKA
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHH
YPELYQESASRQTLDKGITILQGRAVGGGTTVNWTSSFRTPADTLLWWQENHGLAGLSAE
HHHHHHHHHHHHHHHCCCEEEECEECCCCCEEEECCCCCCCCHHEEEEECCCCCCCCCHH
TMRPWFEKAEQRLGIGPWQAEPNGNNLVLERGCQALGLRHARIARNVRGCWNLGYCGMGC
HHHHHHHHHHHHCCCCCCCCCCCCCEEEHCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCC
PTNAKQSMLVTCIPEALSHGARLLSRARVERLLADSGGASIASVQGSLLGADGNTPTGLR
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCEE
FSVRARQVVLAAGAIGTPAIMLRSGLPDAGGQTGKRTFLHPVALSAALMPEMVEPYNGAP
EEEEHEEEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
QTVYSDHYMHTQSLDGPLGFKLEVPPMHPLLASVTFPGFGIEQSQLLQQLPHLHATLALL
CCEECCCEEECCCCCCCCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
RDGFHPDSQGGAVKLRGDGSPALDYPLNDVVWDGVRRSWLAMAELQFAAGASLVMPLHER
HCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHH
AQPMSSWKQTREMIAALPLQALQARLVSAHVMGGMAMGDDPARSVLDGWGRHWTWRNLTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEECEEEE
VDGSAFPTSIGANPQLSIYAFAWRAAERLAEEMAKA
ECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGAKQDKDLSLAADVVIVGSGAGGGIAAEVLSRAGLDVLLLEEGGLYSSSDFRLLEAKA
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHH
YPELYQESASRQTLDKGITILQGRAVGGGTTVNWTSSFRTPADTLLWWQENHGLAGLSAE
HHHHHHHHHHHHHHHCCCEEEECEECCCCCEEEECCCCCCCCHHEEEEECCCCCCCCCHH
TMRPWFEKAEQRLGIGPWQAEPNGNNLVLERGCQALGLRHARIARNVRGCWNLGYCGMGC
HHHHHHHHHHHHCCCCCCCCCCCCCEEEHCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCC
PTNAKQSMLVTCIPEALSHGARLLSRARVERLLADSGGASIASVQGSLLGADGNTPTGLR
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCCEE
FSVRARQVVLAAGAIGTPAIMLRSGLPDAGGQTGKRTFLHPVALSAALMPEMVEPYNGAP
EEEEHEEEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
QTVYSDHYMHTQSLDGPLGFKLEVPPMHPLLASVTFPGFGIEQSQLLQQLPHLHATLALL
CCEECCCEEECCCCCCCCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
RDGFHPDSQGGAVKLRGDGSPALDYPLNDVVWDGVRRSWLAMAELQFAAGASLVMPLHER
HCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHH
AQPMSSWKQTREMIAALPLQALQARLVSAHVMGGMAMGDDPARSVLDGWGRHWTWRNLTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEECEEEE
VDGSAFPTSIGANPQLSIYAFAWRAAERLAEEMAKA
ECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]