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The map label for this gene is hemH [H]

Identifier: 33863508

GI number: 33863508

Start: 1328046

End: 1329221

Strand: Reverse

Name: hemH [H]

Synonym: PMT1240

Alternate gene names: 33863508

Gene position: 1329221-1328046 (Counterclockwise)

Preceding gene: 33863515

Following gene: 33863507

Centisome position: 55.13

GC content: 52.89

Gene sequence:

>1176_bases
ATGGCCCGGGTCGGTGTCCTCTTGATGAACCTAGGGGGGCCTGAACGTATCCAGGATGTAGGGCCTTTTCTCTTTAATAT
TTTTGCCGATCCGGAGATCATTCGGCTGCCTAACCCCGCTCTTCAGAGGCCTTTGGCCTGGTTGATCAGCACGCTGCGCA
GCAGTAAATCCGAGCAGGCTTACCGCTCAATCGGGGGCGGTTCACCTCTGCGGCGGATCACTGAACAACAGGCTCGGGAG
TTGCAGAGCTTGCTTCGGCAACGCGGTATCGATGCCACGAGCTATGTGGCGATGCGTTATTGGCATCCATTCACAGAATC
CGCTGTCGCAGATATCAAAGCTGATGGGATTGATCAGGTGGTGGTGCTTCCCCTCTACCCTCATTTTTCGATTAGTACCA
GTGGCTCGAGTTTTCGAGAGTTGCAGCGCTTGCGACAGACGGATGAATCTTTCCGCAAGCTGCCAATACGTTGTATCCGC
AGCTGGTACGACCACCCTGGATATGTTCGTGCCATGGCGGAGTTGATCGCTGAGCAGGTTCGGCTGAGTGATGTACCTGA
AGAAGCTCAAGTGTTTTTTAGTGCTCATGGAGTGCCCAAGAGCTATGTCGAACAAGCAGGTGATCCATATCAGAAGGAGA
TCGAGGCTTGTACGACTTTGATCATGGCTGAGCTGGAAAACCTTCTTGGCTATGGCAATCCTCATTCCCTTGCCTATCAA
AGTCGAGTGGGTCCAGAGGAATGGATTCAGCCCTATACCGATCAAGTTATTGAGCAGCTTGGTGAGGCTGGTACACGTGA
TTTAGTGGTTGTGCCGATCAGCTTTGTGAGCGAACACATCGAAACTCTCGCCGAGCTTGATATCGAATACCGCGAGCTGG
CGACCGAAGCAGGAATTGTTCATTTCAGGCGGGTGCCTGCTCTTGATACTTACCCCACATTCATTGAGGGTTTGGCCGAT
CTGGTTGGATCCAGTCTTGAGGGGCCAGAGATCAATCTCGATGAGGCTGCCAAGCTGGCCGGTCGAGTGAAGTTCTATCC
CCAGGAGAGATGGCAATGGGGCTTGAATACCAGTTCTGAAGCATGGAATGGACGCATAGCCATGCTTGGGTTTGCGGCTT
TTTTGTTGGAGCTGATCAGTGGCCATGGCCCTTTGCACGCGATCGGTCTGCTCTGA

Upstream 100 bases:

>100_bases
TTGATTAGCTCGTTGCTCAGCTCCATGGCCTTGTAGGGATGGTGCCACCTTGGCGTTGATGGCAGCTACCCTCAAGTCCC
TCTAAAGAACTCTCTTCTCT

Downstream 100 bases:

>100_bases
GTGTTGGCTCGTTAAGGGTCGTCTCACTCTTCTGGTTGGTTCGTCTGTGGGATGACTGTTCTCAACGGAGTCCATTTGTA
TTGGGGCATTCGCCCGCAGG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQARE
LQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIR
SWYDHPGYVRAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
SRVGPEEWIQPYTDQVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIVHFRRVPALDTYPTFIEGLAD
LVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSEAWNGRIAMLGFAAFLLELISGHGPLHAIGLL

Sequences:

>Translated_391_residues
MARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQARE
LQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIR
SWYDHPGYVRAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
SRVGPEEWIQPYTDQVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIVHFRRVPALDTYPTFIEGLAD
LVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSEAWNGRIAMLGFAAFLLELISGHGPLHAIGLL
>Mature_390_residues
ARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQAYRSIGGGSPLRRITEQQAREL
QSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQVVVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRS
WYDHPGYVRAMAELIAEQVRLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQS
RVGPEEWIQPYTDQVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIVHFRRVPALDTYPTFIEGLADL
VGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSEAWNGRIAMLGFAAFLLELISGHGPLHAIGLL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=337, Percent_Identity=37.0919881305638, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI60499021, Length=337, Percent_Identity=37.0919881305638, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=32.3170731707317, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=35.693215339233, Blast_Score=202, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17864156, Length=332, Percent_Identity=34.6385542168675, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=32.183908045977, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552018, Length=173, Percent_Identity=38.728323699422, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 43789; Mature: 43658

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQA
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHH
YRSIGGGSPLRRITEQQARELQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQV
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCE
VVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRSWYDHPGYVRAMAELIAEQV
EEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
HHCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
SRVGPEEWIQPYTDQVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIV
HCCCHHHHHCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHH
HFRRVPALDTYPTFIEGLADLVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSE
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCC
AWNGRIAMLGFAAFLLELISGHGPLHAIGLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ARVGVLLMNLGGPERIQDVGPFLFNIFADPEIIRLPNPALQRPLAWLISTLRSSKSEQA
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCHHHHH
YRSIGGGSPLRRITEQQARELQSLLRQRGIDATSYVAMRYWHPFTESAVADIKADGIDQV
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCE
VVLPLYPHFSISTSGSSFRELQRLRQTDESFRKLPIRCIRSWYDHPGYVRAMAELIAEQV
EEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RLSDVPEEAQVFFSAHGVPKSYVEQAGDPYQKEIEACTTLIMAELENLLGYGNPHSLAYQ
HHCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
SRVGPEEWIQPYTDQVIEQLGEAGTRDLVVVPISFVSEHIETLAELDIEYRELATEAGIV
HCCCHHHHHCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHH
HFRRVPALDTYPTFIEGLADLVGSSLEGPEINLDEAAKLAGRVKFYPQERWQWGLNTSSE
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCC
AWNGRIAMLGFAAFLLELISGHGPLHAIGLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA