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The map label for this gene is ygcA [C]

Identifier: 33863009

GI number: 33863009

Start: 803087

End: 804484

Strand: Direct

Name: ygcA [C]

Synonym: PMT0737

Alternate gene names: 33863009

Gene position: 803087-804484 (Clockwise)

Preceding gene: 33863008

Following gene: 33863011

Centisome position: 33.31

GC content: 40.92

Gene sequence:

>1398_bases
ATGACTAGCTCTACAGACTCAAATTTGACATTAATACCTTCCCCAGGGGATAAGGTTGAGATCACATGCTTAGATTTAGA
TCGTCATGGTAATGGTCTGGCTCGATGGAACAATTGGGTTGTGATAGTCAATGACCTTCTGCCTGGTGAAAGTGCACAAA
TAGAGTTTGTAAGGCGCCATCGAAACCAGTTTTTGGCCCGCAAGGTTCAAACAATTGAGACAGTTGCAAGTCGCAGACCG
CCCCCATGCAAAATCGCTAAGGAATGTGGAGGTTGCTCCATACAACATCTTAGTGATCATGGACAAACCTTATTAAAGCA
AGGTCATCTGCGGCAAATACTTCTACGTTTAGGTCAATTAGATCATAAGATAGAACCAATCATGACGGATTATAATAGAG
CTCTGGGGTATCGAAATAGAGCATTAATTCCTCTATATCGCAATAGTGAAGGACAGTTACATATGGGTTATTACCGACGC
GGCAGTCACCAAATTATTGATCTCAATCGATGTCCGGTTTTGGATCGAGGAATCGATCAATATCTGGCCTCGATTAAGGA
TGATCTTCAACAGCAGAATTGGCCTGCAGATTCTGACCTATCTTCTGGTGAAGGACTCCGGCATCTAGGCATTCGTATTG
GCCAAAAAACAAAACAAGTGCTGATCACACTGGTAAGTAGTACCACTCAACTCTCTGGCCTCCATCAACAAGCCAAGGAA
TGGTATAGTCGGTGGCCGGAAGTAAGAGGAATAACTTTAAACATCCAACGACAGAGGAACAATCTTGTTCTTGGTCAAGA
AACTATATTGCTTGCTGGTGATCTTGAAATTGAGGAGCATTTTTACAATCTCTCCTTATTGCTGTCCACCACAACATTTT
TTCAAGTAAACACTCTTCAGGCAGAACGCATTGTCTCAAAATTAATTGAATGGCTATCCACTGCTTCGCTCGACATTAAT
ATAATTGACGCATATTGTGGAATTGGCACAATTTCTCTCCCCATTGCAGCAACTGGCTATCATGTAATAGGTCTTGAACT
TCATGCAGAAGCTATTACTCAAGCAAATAAAAATGCCTTACGAAATAGTCTTGATAATGTTTCGTTTTTATGCGGTGATG
TTTCCTTATTATTGGCCAAAAAACTTCAACGTAATGATGTGTTGGTGCTAGATCCACCGCGTAAAGGTTTAGATCAAATG
GTGATTAAAACAATCCTTTCAATTCAACCTGAAAGAGTGGCATATCTTAGTTGTGATCCTGCCACATTAGCTCGTGACCT
CAAGCAATTGATCGTACCAAATGGACCCTATCAGATTGATGAATTACAACCCATTGATTTCTTTCCACAAACAATGCATA
TCGAATGTCTGGCACTGTTAACTCGTATTAGCTCCTAA

Upstream 100 bases:

>100_bases
TTATATTTAACAAACCCAGCACCACATATTTGGATACTTATGATTTATTTATAGACAGCATTTACTTTATTGTTATGCCT
AATAAATAGGAAGACTTGCT

Downstream 100 bases:

>100_bases
GCTCTGCAGAAAACTGCTTGACAAGTGCTTGACGTACCTTCTCGTGAATCGGGTTGACCTTGTCTTCACTAAGAGTCCTG
TCTTTACTCCGATAGCGCAA

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTSSTDSNLTLIPSPGDKVEITCLDLDRHGNGLARWNNWVVIVNDLLPGESAQIEFVRRHRNQFLARKVQTIETVASRRP
PPCKIAKECGGCSIQHLSDHGQTLLKQGHLRQILLRLGQLDHKIEPIMTDYNRALGYRNRALIPLYRNSEGQLHMGYYRR
GSHQIIDLNRCPVLDRGIDQYLASIKDDLQQQNWPADSDLSSGEGLRHLGIRIGQKTKQVLITLVSSTTQLSGLHQQAKE
WYSRWPEVRGITLNIQRQRNNLVLGQETILLAGDLEIEEHFYNLSLLLSTTTFFQVNTLQAERIVSKLIEWLSTASLDIN
IIDAYCGIGTISLPIAATGYHVIGLELHAEAITQANKNALRNSLDNVSFLCGDVSLLLAKKLQRNDVLVLDPPRKGLDQM
VIKTILSIQPERVAYLSCDPATLARDLKQLIVPNGPYQIDELQPIDFFPQTMHIECLALLTRISS

Sequences:

>Translated_465_residues
MTSSTDSNLTLIPSPGDKVEITCLDLDRHGNGLARWNNWVVIVNDLLPGESAQIEFVRRHRNQFLARKVQTIETVASRRP
PPCKIAKECGGCSIQHLSDHGQTLLKQGHLRQILLRLGQLDHKIEPIMTDYNRALGYRNRALIPLYRNSEGQLHMGYYRR
GSHQIIDLNRCPVLDRGIDQYLASIKDDLQQQNWPADSDLSSGEGLRHLGIRIGQKTKQVLITLVSSTTQLSGLHQQAKE
WYSRWPEVRGITLNIQRQRNNLVLGQETILLAGDLEIEEHFYNLSLLLSTTTFFQVNTLQAERIVSKLIEWLSTASLDIN
IIDAYCGIGTISLPIAATGYHVIGLELHAEAITQANKNALRNSLDNVSFLCGDVSLLLAKKLQRNDVLVLDPPRKGLDQM
VIKTILSIQPERVAYLSCDPATLARDLKQLIVPNGPYQIDELQPIDFFPQTMHIECLALLTRISS
>Mature_464_residues
TSSTDSNLTLIPSPGDKVEITCLDLDRHGNGLARWNNWVVIVNDLLPGESAQIEFVRRHRNQFLARKVQTIETVASRRPP
PCKIAKECGGCSIQHLSDHGQTLLKQGHLRQILLRLGQLDHKIEPIMTDYNRALGYRNRALIPLYRNSEGQLHMGYYRRG
SHQIIDLNRCPVLDRGIDQYLASIKDDLQQQNWPADSDLSSGEGLRHLGIRIGQKTKQVLITLVSSTTQLSGLHQQAKEW
YSRWPEVRGITLNIQRQRNNLVLGQETILLAGDLEIEEHFYNLSLLLSTTTFFQVNTLQAERIVSKLIEWLSTASLDINI
IDAYCGIGTISLPIAATGYHVIGLELHAEAITQANKNALRNSLDNVSFLCGDVSLLLAKKLQRNDVLVLDPPRKGLDQMV
IKTILSIQPERVAYLSCDPATLARDLKQLIVPNGPYQIDELQPIDFFPQTMHIECLALLTRISS

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=355, Percent_Identity=27.887323943662, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI51173878, Length=355, Percent_Identity=27.887323943662, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI269784678, Length=357, Percent_Identity=27.4509803921569, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI269784680, Length=357, Percent_Identity=27.4509803921569, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI269784676, Length=357, Percent_Identity=27.4509803921569, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI20149688, Length=357, Percent_Identity=27.4509803921569, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789148, Length=450, Percent_Identity=29.1111111111111, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1787083, Length=329, Percent_Identity=24.9240121580547, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1790403, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=440, Percent_Identity=22.7272727272727, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24666579, Length=445, Percent_Identity=24.9438202247191, Blast_Score=115, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y737_PROMM (Q7V7K6)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894569.1
- ProteinModelPortal:   Q7V7K6
- SMR:   Q7V7K6
- STRING:   Q7V7K6
- GeneID:   1727634
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0737
- NMPDR:   fig|74547.1.peg.736
- eggNOG:   COG2265
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- ProtClustDB:   CLSK825974
- BioCyc:   PMAR74547:PMT0737-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 52331; Mature: 52200

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 418-418 BINDING 295-295 BINDING 325-325 BINDING 346-346 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSTDSNLTLIPSPGDKVEITCLDLDRHGNGLARWNNWVVIVNDLLPGESAQIEFVRRH
CCCCCCCCEEEEECCCCEEEEEEEEECCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHH
RNQFLARKVQTIETVASRRPPPCKIAKECGGCSIQHLSDHGQTLLKQGHLRQILLRLGQL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHCC
DHKIEPIMTDYNRALGYRNRALIPLYRNSEGQLHMGYYRRGSHQIIDLNRCPVLDRGIDQ
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCEEEECCCCCCHHCCHHH
YLASIKDDLQQQNWPADSDLSSGEGLRHLGIRIGQKTKQVLITLVSSTTQLSGLHQQAKE
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
WYSRWPEVRGITLNIQRQRNNLVLGQETILLAGDLEIEEHFYNLSLLLSTTTFFQVNTLQ
HHHHCCCCCEEEEEEEECCCCEEECCCEEEEEECCCHHHHHHEEEEEEEEEEEEEEEHHH
AERIVSKLIEWLSTASLDINIIDAYCGIGTISLPIAATGYHVIGLELHAEAITQANKNAL
HHHHHHHHHHHHHHCCCEEEEEEHHCCCCEEEECEEECCEEEEEEEEHHHHHHHHHHHHH
RNSLDNVSFLCGDVSLLLAKKLQRNDVLVLDPPRKGLDQMVIKTILSIQPERVAYLSCDP
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCH
ATLARDLKQLIVPNGPYQIDELQPIDFFPQTMHIECLALLTRISS
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSSTDSNLTLIPSPGDKVEITCLDLDRHGNGLARWNNWVVIVNDLLPGESAQIEFVRRH
CCCCCCCEEEEECCCCEEEEEEEEECCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHH
RNQFLARKVQTIETVASRRPPPCKIAKECGGCSIQHLSDHGQTLLKQGHLRQILLRLGQL
HHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHCC
DHKIEPIMTDYNRALGYRNRALIPLYRNSEGQLHMGYYRRGSHQIIDLNRCPVLDRGIDQ
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCEEEECCCCCCHHCCHHH
YLASIKDDLQQQNWPADSDLSSGEGLRHLGIRIGQKTKQVLITLVSSTTQLSGLHQQAKE
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
WYSRWPEVRGITLNIQRQRNNLVLGQETILLAGDLEIEEHFYNLSLLLSTTTFFQVNTLQ
HHHHCCCCCEEEEEEEECCCCEEECCCEEEEEECCCHHHHHHEEEEEEEEEEEEEEEHHH
AERIVSKLIEWLSTASLDINIIDAYCGIGTISLPIAATGYHVIGLELHAEAITQANKNAL
HHHHHHHHHHHHHHCCCEEEEEEHHCCCCEEEECEEECCEEEEEEEEHHHHHHHHHHHHH
RNSLDNVSFLCGDVSLLLAKKLQRNDVLVLDPPRKGLDQMVIKTILSIQPERVAYLSCDP
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCH
ATLARDLKQLIVPNGPYQIDELQPIDFFPQTMHIECLALLTRISS
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642