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The map label for this gene is pgi [H]

Identifier: 33862986

GI number: 33862986

Start: 770856

End: 772523

Strand: Direct

Name: pgi [H]

Synonym: PMT0714

Alternate gene names: 33862986

Gene position: 770856-772523 (Clockwise)

Preceding gene: 33862984

Following gene: 33862988

Centisome position: 31.97

GC content: 50.12

Gene sequence:

>1668_bases
GTGTCTGAGAAAATGAGCAGGCATTTTGATCGTGGATCGTTTCGAGCTGTGAGCGACGTGCATCAGCTGATGAGTTTCCC
GGATTTCAGCGCCAGCGATGCCCATGTTCAGTGGCAGCGCTTTAACAATTTGCTTTGGCATCACAACGATCTTGGAATTT
GGCTGGACATCAGCCGAATGCATATCAATGCAGAAGATTTTGAACGGCTAGGGCCACGCTTTGATCAGGCTTTCAAGGCC
ATGCAGGCTTTGGAACAGGGAGCTATCGCTAATACTGATGAACAACGGATGGTTGGCCACTACTGGCTGCGTCAGCCGCA
GCTGGCGCCTGATCAAGAGGTCTGTGATCACATTGCCAAGGAAATTGACCTGATTGAGACCTTTGGCAGCAATGTGATCA
ATGGCCTCATCAAAGCCCCCAATGGCAAAAAGTTCACCGATGTGCTTTGGATCGGGATTGGAGGCAGTGGCCTAGGACCT
TTATTAATGATTCGTGCTCTTCAGAATGCAGAGCAGGGATTGCGATTCCATTTTTTCGACAATGTGGATCCTGATGGCAT
GAGTCGCGTTCTTGGCAATCTTGGAGATGCCCTGAGCACGACTTTGGTGGTCACCGTCAGTAAATCTGGTGCAACTCCTG
AACCACACCTCGGCATGGAGCAGGCTCGTCAACGCCTCGAAGCGATGGGAGGTCATTGGGCTGGACAGGCCGTTGCCGTG
ACGATGCTCAATAGCCAGTTAGATCAGCTTGCACAGAAGGAATCCTGGCTTAAGCGTTTTGACATGTTCGATTGGGTTGG
CGGTAGAACAAGCATCACGAGTGCTGTTGGCCTTTTGCCGGCAGCTTTGATTGGTTGTGATATCCGCGCTTTTCTTGCTG
GTGCTGCCCAAATGGATGAGGCCACACGTGTGTCTGATCTGCACAGCAACCCAGCATCTTTGATGGCCGCTGCTTGGTTT
GTTGCAGGAGATGGGCTTGGGCGTCGTGACATGGTTGTTCTTCCATATAGAGATCGCCTTGAGGTCTTTAGTCGTTACCT
GCAACAGCTGGTAATGGAGTCGCTAGGCAAGCGTCTAGATCGGGATGGCAATGTTGTTCATCAAGGCCTTGCTGTATATG
GCAACAAGGGTTCAACTGATCAGCATGCTTATGTGCAGCAATTACGCGATGGTGTTGACAATTTCTTCGCCACATTTATT
GAGGTGCTTGAGGATGTTGAGAACATACCGGCGATCAACAATGAGCATCCAGGTGATTTTCTCGATGGCTTCCTGCAAGG
CACTCGCGCAGCGCTCAGCCAGGGAGGTCGTCAGAGCCTCACCATTTCGATGCGTCGATTTGATCCTCGTCGACTCGGCG
CATTAGTTGCTTTGTTTGAGAGGGCAGTTGGTTTATATGGTGAACTTGTCAATATTAATGCGTATCACCAGCCTGGAGTT
GAATCAGGTAAGAAAGCAGCCGCTGCCATCCTTAACTTGCAGTCTAGAGTTGAAGACTTGCTTGCTGATGGTGTCGAACG
TTCAGCTGGAGAGATCCATCAAGTGATTGGAGATGGGTCAGAAGAAGCCATCTTTTGGATCATGAGGCATCTAACTGCGA
ATAAGCGTGGTTATGTTGCTGAAGGTGATTGGGGAATTCCGACTTCACTACGTTTCAGCAAAGGCTGA

Upstream 100 bases:

>100_bases
AAAGCGAAGCCAGGACTACAAAGTCGGTTAGTCGAAGACCTCTTTTGAGTGTTTGTAGGAGTCCGAAAAGAGTCTTGATC
ATCGCGCGAGGTTAGCCTGA

Downstream 100 bases:

>100_bases
TCATTTCTATGGCACTAGGTTCACCAACTTGCCTGGCACAATGATGATCCGTCTAGGCGATTGACCTTCTAACCATTTGA
CGGCGATGTCACTGTTTAAG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MSEKMSRHFDRGSFRAVSDVHQLMSFPDFSASDAHVQWQRFNNLLWHHNDLGIWLDISRMHINAEDFERLGPRFDQAFKA
MQALEQGAIANTDEQRMVGHYWLRQPQLAPDQEVCDHIAKEIDLIETFGSNVINGLIKAPNGKKFTDVLWIGIGGSGLGP
LLMIRALQNAEQGLRFHFFDNVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEAMGGHWAGQAVAV
TMLNSQLDQLAQKESWLKRFDMFDWVGGRTSITSAVGLLPAALIGCDIRAFLAGAAQMDEATRVSDLHSNPASLMAAAWF
VAGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFI
EVLEDVENIPAINNEHPGDFLDGFLQGTRAALSQGGRQSLTISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGV
ESGKKAAAAILNLQSRVEDLLADGVERSAGEIHQVIGDGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG

Sequences:

>Translated_555_residues
MSEKMSRHFDRGSFRAVSDVHQLMSFPDFSASDAHVQWQRFNNLLWHHNDLGIWLDISRMHINAEDFERLGPRFDQAFKA
MQALEQGAIANTDEQRMVGHYWLRQPQLAPDQEVCDHIAKEIDLIETFGSNVINGLIKAPNGKKFTDVLWIGIGGSGLGP
LLMIRALQNAEQGLRFHFFDNVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEAMGGHWAGQAVAV
TMLNSQLDQLAQKESWLKRFDMFDWVGGRTSITSAVGLLPAALIGCDIRAFLAGAAQMDEATRVSDLHSNPASLMAAAWF
VAGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFI
EVLEDVENIPAINNEHPGDFLDGFLQGTRAALSQGGRQSLTISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGV
ESGKKAAAAILNLQSRVEDLLADGVERSAGEIHQVIGDGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG
>Mature_554_residues
SEKMSRHFDRGSFRAVSDVHQLMSFPDFSASDAHVQWQRFNNLLWHHNDLGIWLDISRMHINAEDFERLGPRFDQAFKAM
QALEQGAIANTDEQRMVGHYWLRQPQLAPDQEVCDHIAKEIDLIETFGSNVINGLIKAPNGKKFTDVLWIGIGGSGLGPL
LMIRALQNAEQGLRFHFFDNVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEAMGGHWAGQAVAVT
MLNSQLDQLAQKESWLKRFDMFDWVGGRTSITSAVGLLPAALIGCDIRAFLAGAAQMDEATRVSDLHSNPASLMAAAWFV
AGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLDRDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFIE
VLEDVENIPAINNEHPGDFLDGFLQGTRAALSQGGRQSLTISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGVE
SGKKAAAAILNLQSRVEDLLADGVERSAGEIHQVIGDGSEEAIFWIMRHLTANKRGYVAEGDWGIPTSLRFSKG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=458, Percent_Identity=29.4759825327511, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI296080693, Length=458, Percent_Identity=26.2008733624454, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1790457, Length=484, Percent_Identity=30.3719008264463, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71996703, Length=479, Percent_Identity=29.6450939457203, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71996708, Length=479, Percent_Identity=29.6450939457203, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319673, Length=492, Percent_Identity=28.4552845528455, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24651916, Length=500, Percent_Identity=29.4, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24651914, Length=500, Percent_Identity=29.4, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI17737445, Length=500, Percent_Identity=29.4, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61405; Mature: 61274

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKMSRHFDRGSFRAVSDVHQLMSFPDFSASDAHVQWQRFNNLLWHHNDLGIWLDISRM
CCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHEEECCCEEEEEEEEE
HINAEDFERLGPRFDQAFKAMQALEQGAIANTDEQRMVGHYWLRQPQLAPDQEVCDHIAK
ECCHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EIDLIETFGSNVINGLIKAPNGKKFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFFD
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECC
NVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEAMGGHWAGQAVAV
CCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
TMLNSQLDQLAQKESWLKRFDMFDWVGGRTSITSAVGLLPAALIGCDIRAFLAGAAQMDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRVSDLHSNPASLMAAAWFVAGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLD
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
RDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFIEVLEDVENIPAINNEHPGDF
CCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LDGFLQGTRAALSQGGRQSLTISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGV
HHHHHHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
ESGKKAAAAILNLQSRVEDLLADGVERSAGEIHQVIGDGSEEAIFWIMRHLTANKRGYVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
EGDWGIPTSLRFSKG
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEKMSRHFDRGSFRAVSDVHQLMSFPDFSASDAHVQWQRFNNLLWHHNDLGIWLDISRM
CCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHEEECCCEEEEEEEEE
HINAEDFERLGPRFDQAFKAMQALEQGAIANTDEQRMVGHYWLRQPQLAPDQEVCDHIAK
ECCHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EIDLIETFGSNVINGLIKAPNGKKFTDVLWIGIGGSGLGPLLMIRALQNAEQGLRFHFFD
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEECC
NVDPDGMSRVLGNLGDALSTTLVVTVSKSGATPEPHLGMEQARQRLEAMGGHWAGQAVAV
CCCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
TMLNSQLDQLAQKESWLKRFDMFDWVGGRTSITSAVGLLPAALIGCDIRAFLAGAAQMDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATRVSDLHSNPASLMAAAWFVAGDGLGRRDMVVLPYRDRLEVFSRYLQQLVMESLGKRLD
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
RDGNVVHQGLAVYGNKGSTDQHAYVQQLRDGVDNFFATFIEVLEDVENIPAINNEHPGDF
CCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LDGFLQGTRAALSQGGRQSLTISMRRFDPRRLGALVALFERAVGLYGELVNINAYHQPGV
HHHHHHHHHHHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
ESGKKAAAAILNLQSRVEDLLADGVERSAGEIHQVIGDGSEEAIFWIMRHLTANKRGYVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
EGDWGIPTSLRFSKG
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]