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The map label for this gene is Dxs [H]

Identifier: 33862957

GI number: 33862957

Start: 740816

End: 742750

Strand: Direct

Name: Dxs [H]

Synonym: PMT0685

Alternate gene names: 33862957

Gene position: 740816-742750 (Clockwise)

Preceding gene: 33862953

Following gene: 33862958

Centisome position: 30.73

GC content: 52.35

Gene sequence:

>1935_bases
ATGCGTCTGAGCGAGTTAACCCATCCGAATCAGCTTCATGGCTTGAGCATTGCCGAGCTTGAGGATGTAGCACGTCAGAT
ACGGGAACGCCATCTTGAGGTGGTGTCCACCAGTGGAGGTCATTTGGGGCCTGGGCTCGGTGTTGTTGAACTCACCCTTG
CTCTTTATCAAACTCTTGATCTAGATCATGATCGAGTTGTATGGGACGTTGGCCATCAGGCTTATCCACACAAGCTGATT
ACTGGTCGATATGGCGACTTCAATACCTTGCGTCAGCAGGGTGGTGTAGCTGGCTATCTGAAGCGTTGTGAAAGTTCTTT
CGATCATTTTGGTGCCGGCCATGCCAGTACCTCGATATCAGCGGCACTCGGCATGGCCGTTGCTCGTGAGCGTCGTGGTG
AATCGTTCAAATGTGTAGCTGTAATTGGTGATGGGGCTCTTACTGGCGGCATAGCACTAGAAGCTATTAATCATGCCGGC
CATATGCCCAATACACCTTTTCTGGTTGTTCTCAACGACAACGACATGTCGATTTCTCCGCCAGTCGGAGCGTTGTCGAC
CCATCTAAACCGCATGCGCCACAGCGCGCCTGTGCAGTTCATCTCGGATAGCGTCGAGGAGAGGGTCAAGAGTCTGCCTT
TCATGGGAGGGGAACTGCCTGCCGAACTCGACCTGCTCAAGGGCAGTATGCGCCGATTATCCGTGCCGAAGGTAGGGGCT
GTTTTTGAGGAGCTTGGCTTCACCTACATGGGCCCTATTGATGGCCATGACATTGAACGCATGGTTCGAACCTTTGAGAC
GGCTCATAAAGTTGGTGGCCCTGTCCTCGTTCATGTTGTTACGACCAAAGGCAAGGGCTATCCCTATGCCGAAGCAGATC
AAGTTGGCTATCACGCGCAATCTGCGTTTGATCTAAGTACTGGGAAAGCTCTTCCCTCAAAAGGAAAGAAACCACCGAGT
TACAGCAAAGTGTTTGGCGAGACGCTCATCAAGCTTTGTCAGCAGGACAGCACTGTCGTTGGGATCACAGCCGCGATGGC
CACAGGTACTGGCCTTGACCTCCTGCAGAAGGCTGTTCCTGAGCAATACATCGATGTAGGTATCGCTGAACAGCATGCTG
TAACTCTTGCTGCTGGGATGGCTTGTGAGGGGCTCAAGCCTGTGCTGGCGATTTACAGCACATTCCTGCAGCGCGCCTTC
GACCAATTGATCCACGACGTGGGGATTCAGAACCTGCCAGTGACCTTTGTGATGGATCGCGCAGGCATTGTTGGCGCTGA
TGGGCCGACCCATCAGGGTCAGTACGACATCAGTTATTTCCGGGCCATTCCTAATTTCACCGTGATGGCGCCCAAGGATG
AGGCTGAACTTCAACGCATGTTGGTGACATGTCTTCAACATCAAGGCCCTGCAGCTCTCCGTATTCCAAGAGGATCAGGA
GAGGGAGTACCTCTGCTTGATGAAGGCTGGAAGCCTTTGGCAATTGGTCGAGGCGAAGTGCTTTGTGAAGGTGATGATCT
TTTAATCGTTGCTTATGGAGTGATGGTGCCTGCTGCGATGATCACAGCTCAGTTGTTGCAGGAAGCAGGTATCAAGGCCA
CTGTGATCAATGCTCGCTTTCTAAGACCACTTGATCAAGCCTTGATTCATCCGTTAGCCCGTCGTATCGGTAGTGTCGTC
ACGATGGAGGAGGGTGCTCTTGCGGGTGGTTTTGGTGCAGCTGTGGTTGAGTCCCTTAGTGATCAAGATGTCTTGGTTCC
AACGTTCCGAATTGGAATCCCTGATCAATTGGTAGACCATGCCAGTCCCCAACAGAGCCGTGAAGCGCTGGGGCTCACAC
CAACACAGATGTCTGAACGAATTCAAGAACACTTTTGCTTGAATTCGAAGCCTTCTCTTGTAGGGCAGGAAGCACCGCAG
GCCCTGTCAACCTGA

Upstream 100 bases:

>100_bases
ATTCAGATCCGTCAACTGTTTGCACTTGCCAGGGTTGCTTTCGTCGTTCTATAGCTGAGAAGACCTAGATTGAATGGGTT
GGAGTGGGACAGGAACGCGA

Downstream 100 bases:

>100_bases
TCAATTGACTGTTTTGGTGGCAGGTGCAGGGCCAGCAGGAGCTCGGCTTGCACAACGACTTGCTAGCCAGGGGATTGCTG
TAACTCTTGTTGAACGCTTA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLI
TGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAG
HMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLSTGKALPSKGKKPPS
YSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAF
DQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
EGVPLLDEGWKPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGIKATVINARFLRPLDQALIHPLARRIGSVV
TMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSKPSLVGQEAPQ
ALST

Sequences:

>Translated_644_residues
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLI
TGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAG
HMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLSTGKALPSKGKKPPS
YSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAF
DQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
EGVPLLDEGWKPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGIKATVINARFLRPLDQALIHPLARRIGSVV
TMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSKPSLVGQEAPQ
ALST
>Mature_644_residues
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLDLDHDRVVWDVGHQAYPHKLI
TGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSISAALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAG
HMPNTPFLVVLNDNDMSISPPVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQSAFDLSTGKALPSKGKKPPS
YSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVPEQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAF
DQLIHDVGIQNLPVTFVMDRAGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
EGVPLLDEGWKPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGIKATVINARFLRPLDQALIHPLARRIGSVV
TMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDHASPQQSREALGLTPTQMSERIQEHFCLNSKPSLVGQEAPQ
ALST

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=618, Percent_Identity=22.3300970873786, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI4507521, Length=618, Percent_Identity=22.3300970873786, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI225637459, Length=535, Percent_Identity=24.8598130841122, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637463, Length=535, Percent_Identity=24.8598130841122, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI225637461, Length=535, Percent_Identity=24.8598130841122, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI133778974, Length=638, Percent_Identity=23.5109717868339, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI4557353, Length=246, Percent_Identity=22.7642276422764, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI34101272, Length=246, Percent_Identity=22.7642276422764, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=44.4805194805195, Blast_Score=500, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17539652, Length=414, Percent_Identity=29.4685990338164, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17538422, Length=244, Percent_Identity=25.8196721311475, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=245, Percent_Identity=25.3061224489796, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551847, Length=651, Percent_Identity=24.7311827956989, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45550715, Length=651, Percent_Identity=24.7311827956989, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645119, Length=607, Percent_Identity=25.2059308072488, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666278, Length=632, Percent_Identity=25.6329113924051, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI21358145, Length=255, Percent_Identity=27.843137254902, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650940, Length=255, Percent_Identity=27.843137254902, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69099; Mature: 69099

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHC
LDHDRVVWDVGHQAYPHKLITGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSIS
CCCCEEEEECCCCCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
AALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAGHMPNTPFLVVLNDNDMSISP
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLSTGKALPSKGKKPPSYSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHHHCC
EQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAFDQLIHDVGIQNLPVTFVMDR
HHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
AGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
CCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
EGVPLLDEGWKPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGIKATVINARF
CCCCCCCCCCCEEEECCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHH
LRPLDQALIHPLARRIGSVVTMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDH
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHC
ASPQQSREALGLTPTQMSERIQEHFCLNSKPSLVGQEAPQALST
CCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MRLSELTHPNQLHGLSIAELEDVARQIRERHLEVVSTSGGHLGPGLGVVELTLALYQTLD
CCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHC
LDHDRVVWDVGHQAYPHKLITGRYGDFNTLRQQGGVAGYLKRCESSFDHFGAGHASTSIS
CCCCEEEEECCCCCCCCCEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHH
AALGMAVARERRGESFKCVAVIGDGALTGGIALEAINHAGHMPNTPFLVVLNDNDMSISP
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
PVGALSTHLNRMRHSAPVQFISDSVEERVKSLPFMGGELPAELDLLKGSMRRLSVPKVGA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
VFEELGFTYMGPIDGHDIERMVRTFETAHKVGGPVLVHVVTTKGKGYPYAEADQVGYHAQ
HHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCCCC
SAFDLSTGKALPSKGKKPPSYSKVFGETLIKLCQQDSTVVGITAAMATGTGLDLLQKAVP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCHHHHHHHCC
EQYIDVGIAEQHAVTLAAGMACEGLKPVLAIYSTFLQRAFDQLIHDVGIQNLPVTFVMDR
HHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
AGIVGADGPTHQGQYDISYFRAIPNFTVMAPKDEAELQRMLVTCLQHQGPAALRIPRGSG
CCEECCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
EGVPLLDEGWKPLAIGRGEVLCEGDDLLIVAYGVMVPAAMITAQLLQEAGIKATVINARF
CCCCCCCCCCCEEEECCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECHHH
LRPLDQALIHPLARRIGSVVTMEEGALAGGFGAAVVESLSDQDVLVPTFRIGIPDQLVDH
HHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHC
ASPQQSREALGLTPTQMSERIQEHFCLNSKPSLVGQEAPQALST
CCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA