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The map label for this gene is purK [H]

Identifier: 33862941

GI number: 33862941

Start: 725834

End: 727033

Strand: Direct

Name: purK [H]

Synonym: PMT0669

Alternate gene names: 33862941

Gene position: 725834-727033 (Clockwise)

Preceding gene: 33862940

Following gene: 33862945

Centisome position: 30.11

GC content: 51.42

Gene sequence:

>1200_bases
GTGGTTGATTCTCTCTGCATGAGCAGCGTTAAAAGCCCAATGATTGGGGTCGTCGGTGGTGGTCAGTTGGCTCAGATGTT
GGCGCAAGCAGCAAAAAGCCGCGCTGTAGATGTTGTCGTGCAGTCTGGATCTGCAATCGATCCCGCTGCTGTTGAAGCAA
CTCGACTTGTCTTGGCCGACCCAGTGGATGTAGAAGCTACTGGCAAGCTCGTGCAGGGGTGTTGTGGCGTCACGTTTGAG
AACGAATGGGTCGATATTGAAGCTCTGATTCCCCTTGAACAACAAGGGGTGTGTTTTTCTCCGTCTCTTACTGCGCTTGC
TCCATTGGTCGACAAAATCTCGCAGCGTCAGTTGCTTCGTGATCTAGATCTTCCTAGCCCTGATTGGACTTTGCTGAGTT
CGATTTCTTTTGCTCAGCCAGAGCTTCCTAGGGAGTGGAACTTTCCGGTGATGGCCAAGTCAAGTCGGTGGGGATATGAC
GGCAAAGGAACCAAGGTTCTCAAGAGTGTCGAGGATTTATCGCAACTTCTGCGCTCAGTGGATCCAACTCAATGGCTGCT
TGAGAGCTGGGTGCCGTTTGAAAAGGAATTAGCCATTGTTGTTAGTCGAGATGCTCAGGGCCGTGTTCGTAGCCTGCCTC
TTGCTGAGACTCATCAGTTCCAACAGGTGTGTGATTGGGTGATTGCACCTGCGAGTGTTGATCATGCTGTGGAAATGATG
GCCTACAACATGGCAGCGTCTCTTCTAACAGAGCTCAATTACGTGGGCGTGCTTGCTGTTGAATTTTTCTACGGACCAGA
CGGACTACAGGTCAATGAAGTTGCACCTCGCACTCATAATTCCGCACATTTTTCGATCGAAGCCTGCAGCAGCAGCCAGT
TTGATCAACAACTTTGTATCGCGGCGGGCTTGCCAGTGCCTGAAACCCATCTCCATGCACCTGGAGCCTTAATGGTAAAT
CTTCTAGGTTTGCAAAAAGGGGGTGAGTCCTCTCTAGATGAGCGCCTAGCGAAGCTGCGCAGTTGTGATCGCTTCCATTT
GCACTGGTATGGAAAAGATTGTGAAACTCCAGGCCGCAAGCTCGGTCATGTGACCGTGCTGCTTAATGGTGTTGATGCGC
CCAGCCGTCAGCTCGAGGCGGAAACTGCCTTAAAGCACATTCGCTCAATTTGGCCGACGCAGGACACCGTTTGCGCTTAA

Upstream 100 bases:

>100_bases
TTTGGTCCTGTTGCTCACTGCTGTGCGTTTGGCCTTTGCTGGTGATCAGGGCTTGCTCTGAAATCTCAATTTTGTTGGGA
TGCAATGCTTGCAGGATTGC

Downstream 100 bases:

>100_bases
ATTCTGCTTGAACTGCTGTGTTGGTGACGGCCTTTTTCTAGTGCTCTGATCTGACTCTCTTTCGATTTGGGGAGGCTGTC
GTGAAGGTGACGTAGACCGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MVDSLCMSSVKSPMIGVVGGGQLAQMLAQAAKSRAVDVVVQSGSAIDPAAVEATRLVLADPVDVEATGKLVQGCCGVTFE
NEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLRDLDLPSPDWTLLSSISFAQPELPREWNFPVMAKSSRWGYD
GKGTKVLKSVEDLSQLLRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHAVEMM
AYNMAASLLTELNYVGVLAVEFFYGPDGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCIAAGLPVPETHLHAPGALMVN
LLGLQKGGESSLDERLAKLRSCDRFHLHWYGKDCETPGRKLGHVTVLLNGVDAPSRQLEAETALKHIRSIWPTQDTVCA

Sequences:

>Translated_399_residues
MVDSLCMSSVKSPMIGVVGGGQLAQMLAQAAKSRAVDVVVQSGSAIDPAAVEATRLVLADPVDVEATGKLVQGCCGVTFE
NEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLRDLDLPSPDWTLLSSISFAQPELPREWNFPVMAKSSRWGYD
GKGTKVLKSVEDLSQLLRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHAVEMM
AYNMAASLLTELNYVGVLAVEFFYGPDGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCIAAGLPVPETHLHAPGALMVN
LLGLQKGGESSLDERLAKLRSCDRFHLHWYGKDCETPGRKLGHVTVLLNGVDAPSRQLEAETALKHIRSIWPTQDTVCA
>Mature_399_residues
MVDSLCMSSVKSPMIGVVGGGQLAQMLAQAAKSRAVDVVVQSGSAIDPAAVEATRLVLADPVDVEATGKLVQGCCGVTFE
NEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLRDLDLPSPDWTLLSSISFAQPELPREWNFPVMAKSSRWGYD
GKGTKVLKSVEDLSQLLRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHAVEMM
AYNMAASLLTELNYVGVLAVEFFYGPDGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCIAAGLPVPETHLHAPGALMVN
LLGLQKGGESSLDERLAKLRSCDRFHLHWYGKDCETPGRKLGHVTVLLNGVDAPSRQLEAETALKHIRSIWPTQDTVCA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=366, Percent_Identity=28.9617486338798, Blast_Score=121, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324702, Length=407, Percent_Identity=29.2383292383292, Blast_Score=166, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43462; Mature: 43462

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSLCMSSVKSPMIGVVGGGQLAQMLAQAAKSRAVDVVVQSGSAIDPAAVEATRLVLAD
CCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHEEEEEEC
PVDVEATGKLVQGCCGVTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLR
CCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
DLDLPSPDWTLLSSISFAQPELPREWNFPVMAKSSRWGYDGKGTKVLKSVEDLSQLLRSV
HCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHC
DPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHAVEMM
CHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
AYNMAASLLTELNYVGVLAVEFFYGPDGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCI
HHHHHHHHHHHHHHHEEEEEEEEECCCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
AAGLPVPETHLHAPGALMVNLLGLQKGGESSLDERLAKLRSCDRFHLHWYGKDCETPGRK
HCCCCCCHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCC
LGHVTVLLNGVDAPSRQLEAETALKHIRSIWPTQDTVCA
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVDSLCMSSVKSPMIGVVGGGQLAQMLAQAAKSRAVDVVVQSGSAIDPAAVEATRLVLAD
CCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHEEEEEEC
PVDVEATGKLVQGCCGVTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLR
CCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHH
DLDLPSPDWTLLSSISFAQPELPREWNFPVMAKSSRWGYDGKGTKVLKSVEDLSQLLRSV
HCCCCCCCHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHC
DPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHAVEMM
CHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
AYNMAASLLTELNYVGVLAVEFFYGPDGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCI
HHHHHHHHHHHHHHHEEEEEEEEECCCCCEECCCCCCCCCCCEEEEEECCCCCHHHHHHH
AAGLPVPETHLHAPGALMVNLLGLQKGGESSLDERLAKLRSCDRFHLHWYGKDCETPGRK
HCCCCCCHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCC
LGHVTVLLNGVDAPSRQLEAETALKHIRSIWPTQDTVCA
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA