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The map label for this gene is hemE [H]

Identifier: 33862718

GI number: 33862718

Start: 503113

End: 504171

Strand: Direct

Name: hemE [H]

Synonym: PMT0445

Alternate gene names: 33862718

Gene position: 503113-504171 (Clockwise)

Preceding gene: 33862717

Following gene: 33862719

Centisome position: 20.87

GC content: 54.67

Gene sequence:

>1059_bases
ATGAGCGACTCCCAGCCCTTATTGCTCCGCGCTGCGCGTGGTGAGTCGGTCGAGCGGACCCCTGTGTGGATGATGCGCCA
GGCGGGTCGCTACATGAAGGTTTACCGGGATCTCCGGGACCGTTACCCCAGTTTTCGAGAGCGTTCTGAAAATCCTGATC
TCTCTTACCAGATCTCGATGCAGCCCTTTGAAGCATTCCAGCCTGATGGGGTGATTTTGTTCTCAGACATCCTCACTCCC
TTGCCCGGCATGGGCATCGATTTCGACATCGTTGAAAGCAAGGGCCCCCTCATCCAAAAGCCGATTCGCAGCCTCAGCCA
AATTGAGGCTCTTCAGCCATTGGAGCCAAACGCAACCATGCCTTTTGTAGGCGAGGTGCTCGGACGCCTGCGCGAGAGTG
TTGGTAATAAGGCTGCTGTGCTGGGTTTTGTGGGGGCTCCCTGGACCCTTGCGGCCTATGTGGTTGAGGGCAAAAGCAGC
AAGAATTACGCCGTGATCAAGGCGATGGCTTTCCAGCAGCCAGATCTTCTGCATCGTTTGCTAAACCATTTCGCTGAATC
GATTGCCACTTATTTGCGTTATCAAATCGATTCCGGCGCCCAGGTCGTGCAGATGTTTGATTCCTGGGCCGGTCAGCTAA
GCCCGGCCGACTACGACACCTTTGCAGCGCCTTATCAAAAAAGAGTCGTAGACCTGGTGAAATCCACTCATCCCGACACT
CCAATGATTCTCTACATCTCCGGCAGCGCTGGAGTGTTGGAACGAATGGGGCGCACAGGTGTCGACATCATTTCTCTTGA
CTGGACTGTTGATATGGCCGATGGCTGCGCTCGACTTCCCGAGCACTTAGGTGTGCAAGGCAATGTTGACCCTGGCCTGT
TGTTTGGAACACCAGAAGCGATTCGAGAGCGAATTGTCGATGCGGTTCGTAAGGCTCGAGGTCGCCGGCACATCCTCAAC
CTCGGCCATGGCATCCTGCCTGGAACACCTGAGGACAATGCCAAAGTGTTTTTCGAAACTGGCAAGACTGTTGACAATCT
GATCGGATCTGCCGCTTGA

Upstream 100 bases:

>100_bases
AAGCCAATGAACATGTGACGAAGCTGCGTTCTCAACATCACTGATGGCCTGAACAACAACGGCCTTCAGGTAGGTTTTCT
GACTGATCCTGACCCTTGTA

Downstream 100 bases:

>100_bases
CTCCTGCCCGGATCCTGATCACAGGAGCCAGCGGCTGTGTTGGGCAGTACACAGCCGCCTGGCTACTTGAAAACTCCGAT
GCCGAGTTACTGCTCTGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISMQPFEAFQPDGVILFSDILTP
LPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATMPFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQQPDLLHRLLNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEAIRERIVDAVRKARGRRHILN
LGHGILPGTPEDNAKVFFETGKTVDNLIGSAA

Sequences:

>Translated_352_residues
MSDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISMQPFEAFQPDGVILFSDILTP
LPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATMPFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSS
KNYAVIKAMAFQQPDLLHRLLNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEAIRERIVDAVRKARGRRHILN
LGHGILPGTPEDNAKVFFETGKTVDNLIGSAA
>Mature_351_residues
SDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISMQPFEAFQPDGVILFSDILTPL
PGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATMPFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSSK
NYAVIKAMAFQQPDLLHRLLNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDTP
MILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEAIRERIVDAVRKARGRRHILNL
GHGILPGTPEDNAKVFFETGKTVDNLIGSAA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=339, Percent_Identity=33.0383480825959, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI2367337, Length=334, Percent_Identity=37.7245508982036, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=345, Percent_Identity=31.5942028985507, Blast_Score=209, Evalue=6e-55,
Organism=Drosophila melanogaster, GI19921920, Length=351, Percent_Identity=35.3276353276353, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI221330099, Length=337, Percent_Identity=35.9050445103858, Blast_Score=228, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38933; Mature: 38802

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISM
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEEC
QPFEAFQPDGVILFSDILTPLPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATM
CHHHHCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSSKNYAVIKAMAFQQPDLLHRL
CHHHHHHHHHHHHHCCCEEEEEECCCCHHEEEEEEECCCCCCEEEEEEHHCCCHHHHHHH
LNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCC
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEA
CEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCHHH
IRERIVDAVRKARGRRHILNLGHGILPGTPEDNAKVFFETGKTVDNLIGSAA
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCC
>Mature Secondary Structure 
SDSQPLLLRAARGESVERTPVWMMRQAGRYMKVYRDLRDRYPSFRERSENPDLSYQISM
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEEEC
QPFEAFQPDGVILFSDILTPLPGMGIDFDIVESKGPLIQKPIRSLSQIEALQPLEPNATM
CHHHHCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PFVGEVLGRLRESVGNKAAVLGFVGAPWTLAAYVVEGKSSKNYAVIKAMAFQQPDLLHRL
CHHHHHHHHHHHHHCCCEEEEEECCCCHHEEEEEEECCCCCCEEEEEEHHCCCHHHHHHH
LNHFAESIATYLRYQIDSGAQVVQMFDSWAGQLSPADYDTFAAPYQKRVVDLVKSTHPDT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCC
PMILYISGSAGVLERMGRTGVDIISLDWTVDMADGCARLPEHLGVQGNVDPGLLFGTPEA
CEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCEEECCHHH
IRERIVDAVRKARGRRHILNLGHGILPGTPEDNAKVFFETGKTVDNLIGSAA
HHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA