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The map label for this gene is thrB [H]

Identifier: 33862699

GI number: 33862699

Start: 477746

End: 478696

Strand: Direct

Name: thrB [H]

Synonym: PMT0426

Alternate gene names: 33862699

Gene position: 477746-478696 (Clockwise)

Preceding gene: 33862698

Following gene: 161350045

Centisome position: 19.82

GC content: 57.41

Gene sequence:

>951_bases
ATGGCGCAGCCGAGTATCGGCCAAAGAATTGTGGTTGACGTACCGTCCACCACAGCCAACCTTGGCCCTGGCTTCGACTG
CCTTGGTGCTGCCCTTGACCTCAACAACCGTTTTGCCATGCGGCGGATCGAAGGGGATAGCGGACGCTTTGAACTCATTA
TTGAAGGCAATGAGGGAAGCCACCTACGCGGTGGGCCCAATAACCTGATTTATCGCGCCGCCCAGAGGGTGTGGAAAGCC
GCAGGGCTCGAACCGGTGGGACTAGAAGCCAAAGTGAGGCTCGCGGTACCCCCCGCAAGAGGCCTAGGAAGCAGTGCCAG
TGCCATCGTGGCAGGGTTGGTCGGAGCCAATGCCTTGGTGGGCGAACCGCTCAGCAAAGAAAAACTGTTGGAACTGGCCA
TTGATATTGAGGGACATCCCGACAATGTGGTTCCTTCTCTTCTGGGAGGTCTTTGCTTGACTGCCAAGGCAGCCTCGCAA
CGCTGGCGGGTGGTTCGTTGTGTCTGGATCAATTCCGTGAAAGCCGTTGTAGCAATCCCCTCTATTCGCCTAAGCACGAG
CGAGGCAAGGCGCGCCATGCCTAAAGACATCCCGATCAGCGATGCCGTAGAAAACCTTGGTGCCCTTACGCTCCTGCTGC
AGGGACTGCGGACAGGAAACGGCGACCTGATCACAGATGGGATGCACGATCGACTGCATGAGCCCTATCGCTGGCCATTA
ATCAAAGGTGGTTTGGATGTTCGCGATGCGGCTCTGAATGCCGGTGCCTGGGGTTGTGCCATCAGCGGAGCTGGCCCCAG
CGTGCTGGCTCTTTGCCCTGAGGATAAAGGGCAAGCAGTCAGTCAGGCAATGGTAAAAGCTTGGGAGGCCGAGGGTGTAG
CAAGTAGGGCTCCACTGCTTAGCATTCAGTCAGGAGGAAGCCACTGGCAACCTCAGATTGAGGATGAGTAG

Upstream 100 bases:

>100_bases
TGGCAGTGATCGATCCCGAGGTGGGCCTGTTCAGTGCAGCCTGCAGAGCACACATGCTTGCTGAGCAAGGTGGGACACTG
ACCTAAGTAGACAAGTAGGG

Downstream 100 bases:

>100_bases
ATATACTCAAGCGCCCGCCCGGGGTTGATCAGTTCCTTCGCATTCTCTTGCCTGCCATGGACGCCAATTTGCCGCTGACG
GCTGCGTCCCAGGCCTCATT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MAQPSIGQRIVVDVPSTTANLGPGFDCLGAALDLNNRFAMRRIEGDSGRFELIIEGNEGSHLRGGPNNLIYRAAQRVWKA
AGLEPVGLEAKVRLAVPPARGLGSSASAIVAGLVGANALVGEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTAKAASQ
RWRVVRCVWINSVKAVVAIPSIRLSTSEARRAMPKDIPISDAVENLGALTLLLQGLRTGNGDLITDGMHDRLHEPYRWPL
IKGGLDVRDAALNAGAWGCAISGAGPSVLALCPEDKGQAVSQAMVKAWEAEGVASRAPLLSIQSGGSHWQPQIEDE

Sequences:

>Translated_316_residues
MAQPSIGQRIVVDVPSTTANLGPGFDCLGAALDLNNRFAMRRIEGDSGRFELIIEGNEGSHLRGGPNNLIYRAAQRVWKA
AGLEPVGLEAKVRLAVPPARGLGSSASAIVAGLVGANALVGEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTAKAASQ
RWRVVRCVWINSVKAVVAIPSIRLSTSEARRAMPKDIPISDAVENLGALTLLLQGLRTGNGDLITDGMHDRLHEPYRWPL
IKGGLDVRDAALNAGAWGCAISGAGPSVLALCPEDKGQAVSQAMVKAWEAEGVASRAPLLSIQSGGSHWQPQIEDE
>Mature_315_residues
AQPSIGQRIVVDVPSTTANLGPGFDCLGAALDLNNRFAMRRIEGDSGRFELIIEGNEGSHLRGGPNNLIYRAAQRVWKAA
GLEPVGLEAKVRLAVPPARGLGSSASAIVAGLVGANALVGEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTAKAASQR
WRVVRCVWINSVKAVVAIPSIRLSTSEARRAMPKDIPISDAVENLGALTLLLQGLRTGNGDLITDGMHDRLHEPYRWPLI
KGGLDVRDAALNAGAWGCAISGAGPSVLALCPEDKGQAVSQAMVKAWEAEGVASRAPLLSIQSGGSHWQPQIEDE

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=281, Percent_Identity=30.9608540925267, Blast_Score=105, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321814, Length=356, Percent_Identity=30.0561797752809, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33235; Mature: 33103

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPSIGQRIVVDVPSTTANLGPGFDCLGAALDLNNRFAMRRIEGDSGRFELIIEGNEGS
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
HLRGGPNNLIYRAAQRVWKAAGLEPVGLEAKVRLAVPPARGLGSSASAIVAGLVGANALV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHH
GEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTAKAASQRWRVVRCVWINSVKAVVAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEC
SIRLSTSEARRAMPKDIPISDAVENLGALTLLLQGLRTGNGDLITDGMHDRLHEPYRWPL
CEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHCCCCCCCE
IKGGLDVRDAALNAGAWGCAISGAGPSVLALCPEDKGQAVSQAMVKAWEAEGVASRAPLL
EECCCCHHHHHHCCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEE
SIQSGGSHWQPQIEDE
EEECCCCCCCCCCCCC
>Mature Secondary Structure 
AQPSIGQRIVVDVPSTTANLGPGFDCLGAALDLNNRFAMRRIEGDSGRFELIIEGNEGS
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
HLRGGPNNLIYRAAQRVWKAAGLEPVGLEAKVRLAVPPARGLGSSASAIVAGLVGANALV
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHH
GEPLSKEKLLELAIDIEGHPDNVVPSLLGGLCLTAKAASQRWRVVRCVWINSVKAVVAIP
CCCCCHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEC
SIRLSTSEARRAMPKDIPISDAVENLGALTLLLQGLRTGNGDLITDGMHDRLHEPYRWPL
CEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHCCCCCCCE
IKGGLDVRDAALNAGAWGCAISGAGPSVLALCPEDKGQAVSQAMVKAWEAEGVASRAPLL
EECCCCHHHHHHCCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEE
SIQSGGSHWQPQIEDE
EEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA