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The map label for this gene is trpS

Identifier: 33862695

GI number: 33862695

Start: 471628

End: 472641

Strand: Direct

Name: trpS

Synonym: PMT0422

Alternate gene names: 33862695

Gene position: 471628-472641 (Clockwise)

Preceding gene: 33862694

Following gene: 33862696

Centisome position: 19.56

GC content: 54.24

Gene sequence:

>1014_bases
ATGCAGCGCCCGCGGGTCCTTTCCGGCGTCCAGCCGACTGGTGCCCTCCATCTGGGTAACTGGTTGGGGGCCATCCGCAA
CTGGGTAGATCTTCAGAGCAGCCATGACACCTATGTCTGTGTCGTGGATTTACATGCCATTACCGTTCCGCACGATCCAG
AACGTTTGGCCGAGGAGTCCCTCTCCACAGCCGCTCTCTACCTGGCCTGTGGGATGGATCCAGATCTCTGCAGCATCTTT
GTGCAGAGCCAGGTTTCCGCCCACAGTGAGCTCTGTTGGTTGCTGAACTGTGTTACGCCTTTGAACTGGCTAGAGCGAAT
GATCCAGTTCAAAGAAAAGTCAGTCAAACAGGGGGACAACGTTTCTGTGGGACTGCTGGACTATCCGGTGTTGATGGCAG
CAGACATTCTTCTTTATGACGCTGATTTGGTGCCTGTGGGCGAAGACCAGAAACAACATTTAGAACTCGCCCGTGACATC
GCTCAGCAGCGCATCAATGCTCGCTTCGGTAGTGAAGAGAAACCTGTCCTTAAAGTTCCAGATCCCCTGATCATTAAAGA
GGGGGCAAGAGTGATGAGCCTTAGCGATGGCCGCAGCAAGATGAGTAAAAGTGACCCCAATGAAGGAAGTCGTATCACAC
TGCTTGATCCGCCTGAACTGATCACAAAAAAAATCAAGCGGGCCAAGACAGACCCCCAAATGGGCTTGCAATTTGGCAAC
CCAGACCGCCCAGAGGCTGACAATCTGCTTGGGATTTACGCCATTCTTAGCGGCCGCGGAAGAGACGCAGCTGCCCAAGA
ATGCGCAGAAATGGGATGGGGAACCTTCAAGCCTCTGCTGGCCGACGCCACGGTGTCAGCCCTTGAGCCGATACAGCATC
GTTATCAACAACTCATGGGCGACCGCATTGAACTCATCAGAGTTCTTGACCAAGGCAGGACAAGAGCGGAAGAGACCGCC
CAAGCAACCCTTCAACGAGTCCGCCAGGCCCTTGGCTTCCTGATAGCCAGCTAA

Upstream 100 bases:

>100_bases
CTTGCACTCAGCAGAGCAAGAGCAGGACCAGGCTGCTGAAACTCAACAAGTGCAGGCAATAGAGCATGAACCTGACAATG
CACCTAGTGAGGGCTGATTA

Downstream 100 bases:

>100_bases
TCAATACAGGCCGAAAGAAAAGCTTGGCTAATCATTGAGGATTAGTGATGGTCGAGGCCTCCTTGTGGCACTGAAGTCAG
CGAGTTCTAGCCATCAGCAA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQRPRVLSGVQPTGALHLGNWLGAIRNWVDLQSSHDTYVCVVDLHAITVPHDPERLAEESLSTAALYLACGMDPDLCSIF
VQSQVSAHSELCWLLNCVTPLNWLERMIQFKEKSVKQGDNVSVGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDI
AQQRINARFGSEEKPVLKVPDPLIIKEGARVMSLSDGRSKMSKSDPNEGSRITLLDPPELITKKIKRAKTDPQMGLQFGN
PDRPEADNLLGIYAILSGRGRDAAAQECAEMGWGTFKPLLADATVSALEPIQHRYQQLMGDRIELIRVLDQGRTRAEETA
QATLQRVRQALGFLIAS

Sequences:

>Translated_337_residues
MQRPRVLSGVQPTGALHLGNWLGAIRNWVDLQSSHDTYVCVVDLHAITVPHDPERLAEESLSTAALYLACGMDPDLCSIF
VQSQVSAHSELCWLLNCVTPLNWLERMIQFKEKSVKQGDNVSVGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDI
AQQRINARFGSEEKPVLKVPDPLIIKEGARVMSLSDGRSKMSKSDPNEGSRITLLDPPELITKKIKRAKTDPQMGLQFGN
PDRPEADNLLGIYAILSGRGRDAAAQECAEMGWGTFKPLLADATVSALEPIQHRYQQLMGDRIELIRVLDQGRTRAEETA
QATLQRVRQALGFLIAS
>Mature_337_residues
MQRPRVLSGVQPTGALHLGNWLGAIRNWVDLQSSHDTYVCVVDLHAITVPHDPERLAEESLSTAALYLACGMDPDLCSIF
VQSQVSAHSELCWLLNCVTPLNWLERMIQFKEKSVKQGDNVSVGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDI
AQQRINARFGSEEKPVLKVPDPLIIKEGARVMSLSDGRSKMSKSDPNEGSRITLLDPPELITKKIKRAKTDPQMGLQFGN
PDRPEADNLLGIYAILSGRGRDAAAQECAEMGWGTFKPLLADATVSALEPIQHRYQQLMGDRIELIRVLDQGRTRAEETA
QATLQRVRQALGFLIAS

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=333, Percent_Identity=41.1411411411411, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI41352700, Length=175, Percent_Identity=52.5714285714286, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1789786, Length=336, Percent_Identity=46.4285714285714, Blast_Score=300, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI71982800, Length=337, Percent_Identity=34.7181008902077, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI71982793, Length=337, Percent_Identity=34.7181008902077, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320474, Length=349, Percent_Identity=36.676217765043, Blast_Score=203, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24666151, Length=333, Percent_Identity=44.1441441441441, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_PROMM (Q7TV34)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894255.1
- ProteinModelPortal:   Q7TV34
- SMR:   Q7TV34
- STRING:   Q7TV34
- GeneID:   1727667
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0422
- NMPDR:   fig|74547.1.peg.422
- eggNOG:   COG0180
- HOGENOM:   HBG293263
- OMA:   NKPGVSN
- ProtClustDB:   PRK00927
- BioCyc:   PMAR74547:PMT0422-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 37323; Mature: 37323

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 203-203

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPRVLSGVQPTGALHLGNWLGAIRNWVDLQSSHDTYVCVVDLHAITVPHDPERLAEES
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCHHHHHHHH
LSTAALYLACGMDPDLCSIFVQSQVSAHSELCWLLNCVTPLNWLERMIQFKEKSVKQGDN
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCC
VSVGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDIAQQRINARFGSEEKPVLKVP
CEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
DPLIIKEGARVMSLSDGRSKMSKSDPNEGSRITLLDPPELITKKIKRAKTDPQMGLQFGN
CCEEECCCCEEEEECCCHHHHCCCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHCCCCCC
PDRPEADNLLGIYAILSGRGRDAAAQECAEMGWGTFKPLLADATVSALEPIQHRYQQLMG
CCCCCCHHHEEHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIELIRVLDQGRTRAEETAQATLQRVRQALGFLIAS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQRPRVLSGVQPTGALHLGNWLGAIRNWVDLQSSHDTYVCVVDLHAITVPHDPERLAEES
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCHHHHHHHH
LSTAALYLACGMDPDLCSIFVQSQVSAHSELCWLLNCVTPLNWLERMIQFKEKSVKQGDN
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCC
VSVGLLDYPVLMAADILLYDADLVPVGEDQKQHLELARDIAQQRINARFGSEEKPVLKVP
CEEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
DPLIIKEGARVMSLSDGRSKMSKSDPNEGSRITLLDPPELITKKIKRAKTDPQMGLQFGN
CCEEECCCCEEEEECCCHHHHCCCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHCCCCCC
PDRPEADNLLGIYAILSGRGRDAAAQECAEMGWGTFKPLLADATVSALEPIQHRYQQLMG
CCCCCCHHHEEHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIELIRVLDQGRTRAEETAQATLQRVRQALGFLIAS
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642