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The map label for this gene is ndhD [H]

Identifier: 161350045

GI number: 161350045

Start: 478753

End: 480324

Strand: Direct

Name: ndhD [H]

Synonym: PMT0427

Alternate gene names: 161350045

Gene position: 478753-480324 (Clockwise)

Preceding gene: 33862699

Following gene: 33862701

Centisome position: 19.86

GC content: 54.13

Gene sequence:

>1572_bases
ATGGACGCCAATTTGCCGCTGACGGCTGCGTCCCAGGCCTCATTTCCCTGGCTTTCCCTGATCGTGTTGCTGCCGGCAAT
GGGTGCCCTGCTGATGCCTCTGTTGCCAAAGAATGAAACAAGTAACTCTCAGGCACCACGCAATTTTGCACTGGTCTTTC
TGCTGGTGGATTTCGTGCTCATGCTGGTTGTATTTAGCCGCATGTTTGATGGTCAGGATGGAGGGCTTCAGCTGGTTGAA
CGGGTTAGCTGGATTCCCTTCATCGGCCTGGAGTGGTCGCTAGGAGCAGACGGCCTTTCGGCTCCTCTGGTTGTGCTTAG
CGGGCTGATCACTCTTCTTGCCGTGGCAGCTAGCTGGAAGGTGCAAAGCAAGACAAGGCTTTATTTCGCCCTGTTGTTGG
TTCAGGCTTCTGCCCAGGGGCTGGTTTTCCTCTCTCAAGATTTCCTGCTGTTCTTTCTTGCTTGGGAACTAGAGCTGGTT
CCGGTCTACCTGTTAATTGCCATCTGGGGCGGAAGCAGACGTCTATATGCCGCCACCAAATTCATTCTCTACACCGCTCT
AGCGTCTTTACTGATTCTGATCAGCGGACTTGCTCTGGCACTTTCGGGTGGTGAGTTCACGCTCAACCTCACTGAGCTGG
CGAATCGATCTCCAGAAGGCAGCCTTGGACTGCTCTGTTATCTGGGCTTTCTGGTGGGCTTTGGCGTAAAGCTACCGATG
TTTCCTCTCCACACCTGGCTGCCAGATGCCCATGGAGAAGCCAACGCACCAGTGTCGATGCTGCTGGCAGGGGTACTCCT
AAAGATGGGTGGCTATGCCCTTTTGCGCTTCAACGTGCAAATGCTGCCTGATGCTCATCTTCAGCTAGCGCCGGCCCTGA
TCGTGATTGGGATCGTCAACATCATCTACGGAGCATTCAACGCCTTTGCTCAAGACAACGTGAAACGACGAATTGCCTGC
AGTTCTGTGAGCCACATGGGCTTCGTTCTGTTGGGTATCGGCGCGATCGATGCTCTCGGGATCAGTGGGGCCATGCTGCA
GATGATCAGCCATGGCCTGATTGCAGCAGCCATGTTTTTCGTCACAGGAACGTTCTACGAACGCACGCAGACCCTCTCCA
TCCCCAATATGGGTGGCCTGGCCAAGGTCTTGCCAATCACCTTCGCTTTTTTCTTGGCCAGCTCTCTGGCTTCCCTCGCC
CTGCCAGGAATGAGCGGCTTTGTCAGTGAAATCACCGTCTTCCTCGGCATCATTAGTCAGGAAGGATTCACTTCAATATT
CAGGGTTATCACGATCGTGCTGGCGGCGATTGGACTGGTGCTTACCCCCGTCTATTTGCTGTCGATGTGTCGACGGGTCT
TTTTTGGCCCCAGGATTCCCGCCCTTGCAATGATCGAAGACATCAACCCCAGAGAGCTGACCATTGGGCTCAGTTTGATT
GTGCCCACGTTGGTGATCGGATTTTGGCCTCGAGTCGCCATCGATCTCTATGAGGCTTCAACCAATGCTCTCGCTGATCG
ACTGATTAGCCATAGCTTGGCAGCCCAAGGTTCCCTGCTACCCCTTGGCTGA

Upstream 100 bases:

>100_bases
AGTCAGGAGGAAGCCACTGGCAACCTCAGATTGAGGATGAGTAGATATACTCAAGCGCCCGCCCGGGGTTGATCAGTTCC
TTCGCATTCTCTTGCCTGCC

Downstream 100 bases:

>100_bases
ATAATGCCTGTTGCTGTGAACGAAATAAAGTCATCAGCCCTCCTCCAGGGTGAAGGAATCCCAAACTTCACTGCCATTAC
TGCTCAACAAGTTCAGGATC

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPKNETSNSQAPRNFALVFLLVDFVLMLVVFSRMFDGQDGGLQLVE
RVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWKVQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELV
PVYLLIAIWGGSRRLYAATKFILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVNIIYGAFNAFAQDNVKRRIAC
SSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFFVTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLA
LPGMSGFVSEITVFLGIISQEGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLAAQGSLLPLG

Sequences:

>Translated_523_residues
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPKNETSNSQAPRNFALVFLLVDFVLMLVVFSRMFDGQDGGLQLVE
RVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWKVQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELV
PVYLLIAIWGGSRRLYAATKFILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVNIIYGAFNAFAQDNVKRRIAC
SSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFFVTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLA
LPGMSGFVSEITVFLGIISQEGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLAAQGSLLPLG
>Mature_523_residues
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPKNETSNSQAPRNFALVFLLVDFVLMLVVFSRMFDGQDGGLQLVE
RVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWKVQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELV
PVYLLIAIWGGSRRLYAATKFILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVNIIYGAFNAFAQDNVKRRIAC
SSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFFVTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLA
LPGMSGFVSEITVFLGIISQEGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLAAQGSLLPLG

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=376, Percent_Identity=29.7872340425532, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI251831117, Length=376, Percent_Identity=25.531914893617, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1788613, Length=521, Percent_Identity=37.8119001919386, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788831, Length=279, Percent_Identity=29.7491039426523, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788827, Length=235, Percent_Identity=31.9148936170213, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788829, Length=298, Percent_Identity=27.1812080536913, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI2367154, Length=261, Percent_Identity=28.3524904214559, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788614, Length=380, Percent_Identity=27.6315789473684, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693160, Length=224, Percent_Identity=31.25, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 56104; Mature: 56104

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPKNETSNSQAPRNFALVFLLVDFVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MLVVFSRMFDGQDGGLQLVERVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWK
HHHHHHHHHCCCCCHHHHHHHHCCCCEECEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
VQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELVPVYLLIAIWGGSRRLYAATK
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
HHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVN
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHEECCCCHHHHHHHHHHHHHHH
IIYGAFNAFAQDNVKRRIACSSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFVSEITVFLGIISQ
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
EGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHH
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLAAQGSLLPLG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDANLPLTAASQASFPWLSLIVLLPAMGALLMPLLPKNETSNSQAPRNFALVFLLVDFVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MLVVFSRMFDGQDGGLQLVERVSWIPFIGLEWSLGADGLSAPLVVLSGLITLLAVAASWK
HHHHHHHHHCCCCCHHHHHHHHCCCCEECEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
VQSKTRLYFALLLVQASAQGLVFLSQDFLLFFLAWELELVPVYLLIAIWGGSRRLYAATK
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FILYTALASLLILISGLALALSGGEFTLNLTELANRSPEGSLGLLCYLGFLVGFGVKLPM
HHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
FPLHTWLPDAHGEANAPVSMLLAGVLLKMGGYALLRFNVQMLPDAHLQLAPALIVIGIVN
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHEECCCCHHHHHHHHHHHHHHH
IIYGAFNAFAQDNVKRRIACSSVSHMGFVLLGIGAIDALGISGAMLQMISHGLIAAAMFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VTGTFYERTQTLSIPNMGGLAKVLPITFAFFLASSLASLALPGMSGFVSEITVFLGIISQ
HHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
EGFTSIFRVITIVLAAIGLVLTPVYLLSMCRRVFFGPRIPALAMIEDINPRELTIGLSLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHH
VPTLVIGFWPRVAIDLYEASTNALADRLISHSLAAQGSLLPLG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA