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The map label for this gene is vpsC

Identifier: 30064531

GI number: 30064531

Start: 3321208

End: 3321759

Strand: Reverse

Name: vpsC

Synonym: S3451

Alternate gene names: 30064531

Gene position: 3321759-3321208 (Counterclockwise)

Preceding gene: 30064532

Following gene: 30064530

Centisome position: 72.22

GC content: 49.82

Gene sequence:

>552_bases
ATGCAAACGAAAAAAAATGAAATTTGGGTGGGTATCTTTTTATTAGCAGCACTGCTGGCGGCGCTGTTTGTTTGCCTGAA
GGCGGCGAACGTGACGTCCATACGTACTGAATCGACCTACACGCTTTATGCGACGTTCGATAACATTGGCGGCCTGAAAG
CGCGCTCTCCGGTCAGCATTGGTGGTGTTGTTGTGGGCCGGGTGGCGGATATTACGCTGGACCCGAAAACCTATCTGCCG
CGCGTAACGCTGGAAATTGAACAACGTTATAACCACATTCCTGATACCAGTTCGCTGAGCATTCGTACTTCCGGCCTGCT
GGGAGAACAATATCTGGCATTAAACGTCGGTTTTGAAGACCCGGAACTGGGGACTGCTATCCTGAAGGATGGCGATACAA
TTCAGGACACCAAGTCTGCGATGGTGCTGGAAGATCTCATTGGTCAGTTCCTTTACGGTAGTAAAGGCGATGACAATAAG
AATAGTGGCGATGCGCCAGCTGCTGCGCCAGGTAATAATGAAACCACTGAACCTGTGGGTACAACGAAATAA

Upstream 100 bases:

>100_bases
GGGATTAGCCGGGCAACCACTCGCACCGTTGTCCACTCGTCTCTGGCTGTTCTGGGGCTGGATTTTGTGCTGACCGCATT
GATGTTTGGGAATTGAGTTC

Downstream 100 bases:

>100_bases
TTTCAGGAGAACCGACGCATGTTTAAACGTTTAATGATGGTCGCTTTGCTGGTGATTGCACCTCTGAGTGCGGCAACCGC
GGCAGACCAGACCAATCCTT

Product: cytoplasmic membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MQTKKNEIWVGIFLLAALLAALFVCLKAANVTSIRTESTYTLYATFDNIGGLKARSPVSIGGVVVGRVADITLDPKTYLP
RVTLEIEQRYNHIPDTSSLSIRTSGLLGEQYLALNVGFEDPELGTAILKDGDTIQDTKSAMVLEDLIGQFLYGSKGDDNK
NSGDAPAAAPGNNETTEPVGTTK

Sequences:

>Translated_183_residues
MQTKKNEIWVGIFLLAALLAALFVCLKAANVTSIRTESTYTLYATFDNIGGLKARSPVSIGGVVVGRVADITLDPKTYLP
RVTLEIEQRYNHIPDTSSLSIRTSGLLGEQYLALNVGFEDPELGTAILKDGDTIQDTKSAMVLEDLIGQFLYGSKGDDNK
NSGDAPAAAPGNNETTEPVGTTK
>Mature_183_residues
MQTKKNEIWVGIFLLAALLAALFVCLKAANVTSIRTESTYTLYATFDNIGGLKARSPVSIGGVVVGRVADITLDPKTYLP
RVTLEIEQRYNHIPDTSSLSIRTSGLLGEQYLALNVGFEDPELGTAILKDGDTIQDTKSAMVLEDLIGQFLYGSKGDDNK
NSGDAPAAAPGNNETTEPVGTTK

Specific function: Part of the ABC transporter complex mlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner memb

COG id: COG1463

COG function: function code Q; ABC-type transport system involved in resistance to organic solvents, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaD family [H]

Homologues:

Organism=Escherichia coli, GI1789584, Length=183, Percent_Identity=99.4535519125683, Blast_Score=369, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003399 [H]

Pfam domain/function: PF02470 MCE [H]

EC number: NA

Molecular weight: Translated: 19566; Mature: 19566

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKKNEIWVGIFLLAALLAALFVCLKAANVTSIRTESTYTLYATFDNIGGLKARSPVSI
CCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEECCCCCCCCCCCCCC
GGVVVGRVADITLDPKTYLPRVTLEIEQRYNHIPDTSSLSIRTSGLLGEQYLALNVGFED
CCEEEEEEEEEEECCHHHCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCEEEEEECCCCC
PELGTAILKDGDTIQDTKSAMVLEDLIGQFLYGSKGDDNKNSGDAPAAAPGNNETTEPVG
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TTK
CCC
>Mature Secondary Structure
MQTKKNEIWVGIFLLAALLAALFVCLKAANVTSIRTESTYTLYATFDNIGGLKARSPVSI
CCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEECCCCCCCCCCCCCC
GGVVVGRVADITLDPKTYLPRVTLEIEQRYNHIPDTSSLSIRTSGLLGEQYLALNVGFED
CCEEEEEEEEEEECCHHHCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCEEEEEECCCCC
PELGTAILKDGDTIQDTKSAMVLEDLIGQFLYGSKGDDNKNSGDAPAAAPGNNETTEPVG
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TTK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]