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The map label for this gene is lysR

Identifier: 30064180

GI number: 30064180

Start: 2934063

End: 2934998

Strand: Direct

Name: lysR

Synonym: S3047

Alternate gene names: 30064180

Gene position: 2934063-2934998 (Clockwise)

Preceding gene: 30064178

Following gene: 30064186

Centisome position: 63.79

GC content: 53.1

Gene sequence:

>936_bases
ATGGCCGCCGTTAACTTACGTCATATTGAAATTTTTCATGCGGTAATGACCGCCGGAAGCCTGACTGAGGCAGCACACCT
GCTACACACCTCACAGCCAACCGTCAGCCGCGAACTGGCGCGCTTTGAGAAGGTGATCGGGCTGAAATTGTTTGAGCGCG
TACGTGGACGATTACATCCTACCGTGCAAGGACTGCGTCTGTTTGAAGAAGTGCAACGATCCTGGTACGGACTGGATCGC
ATTGTCAGCGCCGCAGAAAGTCTGCGCGAGTTTCGCCAGGGAGAACTGTCTATTGCCTGCCTGCCGGTCTTTTCGCAATC
TTTTTTACCGCAGCTCCTGCAACCCTTTCTGGCACGTTATCCCGATGTCAGCTTAAATATCGTGCCCCAGGAATCACCGC
TACTTGAAGAGTGGCTCTCGGCCCAGCGTCATGATTTAGGACTCACTGAGACACTCCATACGCCTACGGGAACAGAACGT
ACCGAATTACTCTCTTTAGATGAAGTGTGTGTGTTACCTCCGGGTCATCCGCTGGCGGTAAAAAAGGTATTAACGCCGGA
TGATTTTCAGGGTGAGAATTACATCAGCCTTTCCCGTACTGACAGCTATCGCCAGTTGCTGGATCAGCTATTTACTGAAC
ATCAGGTTAAACGACGCATGATCGTAGAAACCCACAGCGCCGCGTCAGTCTGCGCAATGGTACGGGCGGGGGTAGGTATT
TCGGTGGTTAACCCGCTCACCGCACTAGATTATGCGGCAAGCGGTTTAGTGGTGCGGCGGTTCAGTATTGCGGTTCCGTT
CACCGTCAGCCTGATCCGCCCCCTGCACCGCCCGTCATCAGCGCTGGTTCAGGCGTTTAGTGGGCATTTACAAGCGGGGT
TACCGAAACTGGTCACTTCTCTTGACGCTATTTTGTCGTCAGCTACGACAGCATAA

Upstream 100 bases:

>100_bases
TTTTTATGATTACGCCACATCATAAAAAGAATAAAAAATATCGATTTATGTCGAGTCTATGCAAAAATGATATGGATTAC
CGGATTGCGAGAGAGCGCTA

Downstream 100 bases:

>100_bases
AAGCGACAGCATCCTCGGCATGGATCGCCGCGGTATCAAACACAGGCAAAACACTGCGCTCTTCTGGCACCAGTAAACCA
ATTTCTGTGCAGCCAAAAAT

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPTGTER
TELLSLDEVCVLPPGHPLAVKKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGI
SVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTSLDAILSSATTA

Sequences:

>Translated_311_residues
MAAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPTGTER
TELLSLDEVCVLPPGHPLAVKKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGI
SVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTSLDAILSSATTA
>Mature_310_residues
AAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGLRLFEEVQRSWYGLDRI
VSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPTGTERT
ELLSLDEVCVLPPGHPLAVKKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGIS
VVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTSLDAILSSATTA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=311, Percent_Identity=99.6784565916399, Blast_Score=625, Evalue=0.0,
Organism=Escherichia coli, GI157672245, Length=284, Percent_Identity=27.8169014084507, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693105, Length=268, Percent_Identity=24.2537313432836, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788887, Length=319, Percent_Identity=26.0188087774295, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787530, Length=262, Percent_Identity=25.9541984732824, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788481, Length=274, Percent_Identity=26.6423357664234, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=24.4897959183673, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790262, Length=264, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081904, Length=187, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=26.2948207171315, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34395; Mature: 34264

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHP
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHC
PDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPTGTERTELLSLDEVCVLPPGHPLAV
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHCCCCCEEECCCCCCHHH
KKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGI
HCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTS
HHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHH
LDAILSSATTA
HHHHHHHCCCC
>Mature Secondary Structure 
AAVNLRHIEIFHAVMTAGSLTEAAHLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHP
CCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPQLLQPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHC
PDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHTPTGTERTELLSLDEVCVLPPGHPLAV
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHCCCCCEEECCCCCCHHH
KKVLTPDDFQGENYISLSRTDSYRQLLDQLFTEHQVKRRMIVETHSAASVCAMVRAGVGI
HCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SVVNPLTALDYAASGLVVRRFSIAVPFTVSLIRPLHRPSSALVQAFSGHLQAGLPKLVTS
HHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHH
LDAILSSATTA
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]