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The map label for this gene is tyrP

Identifier: 30063354

GI number: 30063354

Start: 1962619

End: 1963830

Strand: Direct

Name: tyrP

Synonym: S2046

Alternate gene names: 30063354

Gene position: 1962619-1963830 (Clockwise)

Preceding gene: 30063352

Following gene: 30063359

Centisome position: 42.67

GC content: 50.91

Gene sequence:

>1212_bases
GTGAAAAACAGAACCCTGGGAAGTGTTTTTATCGTGGCGGGAACCACAATTGGCGCAGGCATGCTGGCAATGCCGCTGGC
TGCGGCCGGTGTTGGTTTTAGCGTTACGTTAATCTTGTTGATTGGGCTTTGGGCGTTGATGTGCTACACGGCGCTATTAC
TGCTGGAGGTGTACCAGCATGTTCCGGCAGATACCGGTCTGGGCACGCTGGCAAAACGCTATCTGGGACGCTACGGTCAA
TGGCTGACAGGCTTCAGTATGATGTTCTTAATGTATGCTCTGACTGCAGCATACATCAGCGGTGCCGGTGAATTGTTGGC
CTCCAGCATCAGCGACTGGACAGGTATTTCAATGTCGGCAACCGCTGGCGTGCTGTTGTTCACTTTTGTTGCCGGTGGCG
TGGTTTGTGTTGGAACATCGCTGGTCGATTTATTTAACCGTTTTCTGTTCAGCGCCAAAATTATTTTTCTGGTGGTGATG
CTGGTATTGCTGCTACCGCATATTCACAAAGTGAATCTTTTAACCCTGCCGTTGCAACAGGGGCTGGCACTGTCTGCAAT
CCCGGTGATTTTTACGTCGTTTGGTTTTCACGGTAGCGTGCCGAGTATTGTCAGCTATATGGATGGCAACATTCGTAAGC
TACGCTGGGTGTTTATAATCGGTAGTGCCATCCCCCTGGTGGCATATATTTTCTGGCAGGTGGCGACGCTTGGCAGCATT
GATTCAACAACCTTTATGGGATTGCTGGCTAATCATGCTGGATTAAACGGGCTGTTACAGGCGTTACGCGAAATGGTGGC
CTCTCCGCATGTTGAGCTGGCGGTGCATTTATTTGCTGATTTAGCCCTCGCCACGTCATTTCTCGGCGTTGCGTTAGGCT
TATTTGATTATCTGGCTGATTTGTTTCAGCGTTCAAATACCGTTGGTGGACGATTGCAAACTGGTGCAATTACCTTTCTG
CCGCCGTTGGCGTTTGCACTGTTTTATCCACGAGGATTTGTGATGGCGCTGGGTTACGCCGGTGTGGCGCTGGCGGTACT
GGCATTGATTATCCCTTCACTATTGACCTGGCAAAGCAGAAAGCACAATCCTCAGGCGGGTTACCGGGTCAAAGGTGGTC
GTCCGGCGCTGGTGGTGGTGTTTCTCTGTGGTATTGCTGTGATTGGCGTGCAATTTTTGATTGCGGCAGGGTTGTTACCA
GAAGTGGGGTGA

Upstream 100 bases:

>100_bases
ATATTTACACAATATGTAACGTCGGTTTGACGAAGCAGCCGTTATGCCTTAACCTGCGCCGCAGATATCACTCATAAAGA
TCGTCAGGACAGAAGAAAGC

Downstream 100 bases:

>100_bases
TCAGATAGCCTCAAATTCCTTATTGGGTGCCAGAATTAACGCTGACACCCAATGTGACCTCTTAATGCAGGCAGCACTGC
TTAAATTTCTTACCACTGCC

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQHVPADTGLGTLAKRYLGRYGQ
WLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSATAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVM
LVLLLPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFIIGSAIPLVAYIFWQVATLGSI
DSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRSNTVGGRLQTGAITFL
PPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSRKHNPQAGYRVKGGRPALVVVFLCGIAVIGVQFLIAAGLLP
EVG

Sequences:

>Translated_403_residues
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQHVPADTGLGTLAKRYLGRYGQ
WLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSATAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVM
LVLLLPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFIIGSAIPLVAYIFWQVATLGSI
DSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRSNTVGGRLQTGAITFL
PPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSRKHNPQAGYRVKGGRPALVVVFLCGIAVIGVQFLIAAGLLP
EVG
>Mature_403_residues
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQHVPADTGLGTLAKRYLGRYGQ
WLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSATAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVM
LVLLLPHIHKVNLLTLPLQQGLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFIIGSAIPLVAYIFWQVATLGSI
DSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLADLFQRSNTVGGRLQTGAITFL
PPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSRKHNPQAGYRVKGGRPALVVVFLCGIAVIGVQFLIAAGLLP
EVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=100, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI1789552, Length=384, Percent_Identity=32.2916666666667, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1790145, Length=410, Percent_Identity=32.9268292682927, Blast_Score=198, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYRP_ECOLI (P0AAD4)

Other databases:

- EMBL:   M23240
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   C64954
- RefSeq:   AP_002525.1
- RefSeq:   NP_416420.1
- ProteinModelPortal:   P0AAD4
- DIP:   DIP-48105N
- MINT:   MINT-1305835
- STRING:   P0AAD4
- EnsemblBacteria:   EBESCT00000002514
- EnsemblBacteria:   EBESCT00000002515
- EnsemblBacteria:   EBESCT00000016717
- GeneID:   946412
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1895
- KEGG:   eco:b1907
- EchoBASE:   EB1034
- EcoGene:   EG11041
- eggNOG:   COG0814
- GeneTree:   EBGT00050000009663
- HOGENOM:   HBG482321
- OMA:   SMLFLMY
- ProtClustDB:   PRK15132
- BioCyc:   EcoCyc:TYRP-MONOMER
- Genevestigator:   P0AAD4
- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227
- PRINTS:   PR00166
- TIGRFAMs:   TIGR00837

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 42820; Mature: 42820

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12fdf07c)-; HASH(0x12d52cd0)-; HASH(0x12d50fcc)-; HASH(0x1330dbdc)-; HASH(0x132b9b0c)-; HASH(0x132867ac)-; HASH(0x12ecd0fc)-; HASH(0x13604978)-; HASH(0x1311ed50)-; HASH(0x1344e644)-; HASH(0xf7e9dc4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQH
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPADTGLGTLAKRYLGRYGQWLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVMLVLLLPHIHKVNLLTLPLQQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHC
GLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFIIGSAIPLVAYIFWQVATLGSI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHCCCC
DSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLAD
CHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQRSNTVGGRLQTGAITFLPPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSR
HHHCCCCCCCEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KHNPQAGYRVKGGRPALVVVFLCGIAVIGVQFLIAAGLLPEVG
CCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLILLIGLWALMCYTALLLLEVYQH
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPADTGLGTLAKRYLGRYGQWLTGFSMMFLMYALTAAYISGAGELLASSISDWTGISMSA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TAGVLLFTFVAGGVVCVGTSLVDLFNRFLFSAKIIFLVVMLVLLLPHIHKVNLLTLPLQQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHC
GLALSAIPVIFTSFGFHGSVPSIVSYMDGNIRKLRWVFIIGSAIPLVAYIFWQVATLGSI
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHCCCC
DSTTFMGLLANHAGLNGLLQALREMVASPHVELAVHLFADLALATSFLGVALGLFDYLAD
CHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQRSNTVGGRLQTGAITFLPPLAFALFYPRGFVMALGYAGVALAVLALIIPSLLTWQSR
HHHCCCCCCCEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KHNPQAGYRVKGGRPALVVVFLCGIAVIGVQFLIAAGLLPEVG
CCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503