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The map label for this gene is yebK

Identifier: 30063264

GI number: 30063264

Start: 1869719

End: 1870540

Strand: Direct

Name: yebK

Synonym: S1929

Alternate gene names: 30063264

Gene position: 1869719-1870540 (Clockwise)

Preceding gene: 30063260

Following gene: 30063265

Centisome position: 40.65

GC content: 50.36

Gene sequence:

>822_bases
ATGAATATGCTGGAAAAAATCCAGTCTCAGCTGGAACATTTGAGCAAATCAGAGCGCAAAGTTGCCGAGGTCATTCTGGC
TTCGCCCGATAACGCGATCCATTCGAGTATTGCTGCTCTGGCGCTGGAAGCCAATGTTAGCGAACCGACGGTGAATCGTT
TCTGTCGCAGCATGGACACGCGCGGTTTTCCTGATTTTAAACTTCATCTGGCACAAAGTCTGGCGAATGGCACTCCCTAT
GTTAATCGCAACGTCAATGAAGATGACAGCGTTGAATCATACACGGGGAAAATATTTGAGTCCGCAATGGCAACGCTCGA
TCATGTCCGTCATTCACTGGATAAATCTGCCATCAACCGCACCGTCGACTTGCTCACTCAGGCAAAAAAAATCGCCTTTT
TCGGATTAGGCTCTTCTGCCGCCGTTGCCCACGATGCGATGAATAAGTTCTTTCGTTTTAATGTTCCGGTGGTGTACTCC
GATGATATCGTGCTGCAACGCATGAGTTGTATGAATTGTAGCGACGGAGACGTGGTGGTGCTGATTTCTCACACAGGAAG
AACAAAAAATCTGGTCGAGCTGGCGCAGCTGGCACGCGAAAACGACGCCATGGTGATTGCCCTCACCTCTGCGGGTACCC
CGCTCGCCCGGGAAGCAACGCTGGCAATTACCCTCGACGTACCGGAAGATACTGACATTTATATGCCCATGGTTTCTCGA
CTTGCACAGCTGACCGTGATAGATGTGCTGGCGACAGGATTTACTTTGCGACGCGGTGCAAAATTCAGAGATAACTTGAA
GCGGTCAAGGAAGCGGCGGTGA

Upstream 100 bases:

>100_bases
TTTTGTCATTAACACGGCACACAGGCGTAATATCTGACAAAACTGCATTTCGATTTCTTTCAGTGCGGAAATCGTCATTA
CCCGTGAGTCTCTTTACATC

Downstream 100 bases:

>100_bases
AGGAATCGCGTTTTGATAAGCAGTTACTTAATTTAAGTGACGATCGCTAAAAGCGACTGTCACTGTCCTAATCTTATACG
ACATCCGAATGAGATTAATT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPY
VNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRTVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYS
DDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRSRKRR

Sequences:

>Translated_273_residues
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPY
VNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRTVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYS
DDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRSRKRR
>Mature_273_residues
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPY
VNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRTVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYS
DDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRSRKRR

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=271, Percent_Identity=98.1549815498155, Blast_Score=549, Evalue=1e-158,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=24.1666666666667, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788767, Length=264, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI87082130, Length=195, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 30185; Mature: 30185

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RGFPDFKLHLAQSLANGTPYVNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYSDDIVLQRMSCMNCSDGDVVV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRSRKRR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RGFPDFKLHLAQSLANGTPYVNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYSDDIVLQRMSCMNCSDGDVVV
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRSRKRR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]