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The map label for this gene is gpmA

Identifier: 29346515

GI number: 29346515

Start: 1393599

End: 1394348

Strand: Reverse

Name: gpmA

Synonym: BT_1105

Alternate gene names: 29346515

Gene position: 1394348-1393599 (Counterclockwise)

Preceding gene: 29346516

Following gene: 29346514

Centisome position: 22.27

GC content: 47.87

Gene sequence:

>750_bases
ATGAAAAGAATAGTGTTATTACGTCATGGCGAAAGTCTATGGAACAAAGAAAACCGTTTTACTGGATGGACGGACGTGGA
TTTAAGCGAGAAAGGAGTTGAAGAAGCCTGCAAGGCAGGCGATGCATTACGGGAGGCTGGATTTTCTTTTGAGGCAGCTT
ACACTTCTTACTTGAAACGTGCCGTAAAAACGTTGAACTGTGTCTTGGACCGGCTGGATAAAGACTGGATTCCGGTTGAA
AAGACCTGGCGGCTGAACGAGAAGCATTACGGTATGCTTCAGGGACTGAATAAGAGTGAAACAGCGGTCCAATATGGTGA
AGAACAAGTACACATCTGGCGAAGAAGCTATGACGTGGCTCCCGCTCCGGTAGGCAAAGATGATCCCCGTAATCCGGGCA
TGGATATCCGCTATGCCGGTGTACCAGATAGCGAACTTCCCCGTACGGAATCCCTGAAAGATACTATTGGGCGTGTCATG
CCTTACTGGAAATGCATCATCTTTCCCGCATTGATGTATAAGGACAGCCTGCTGGTAGTCGCCCATGGTAACAGCCTGCG
CGGAATCATCAAGCATCTCAAAGGAATTTCCGATACGGATATTTCCAACCTGAACCTGCCTACGGCAGTTCCTTATGTCT
TTGAATTTGACGACAGGCTGGTTCTTGTCAAGGACTACTACCTTGGAAACCCGGAAGAGATACGGAAACGGGCAGAAGCT
GTGGCCAAACAAGGGATGGCTAAAAAATAA

Upstream 100 bases:

>100_bases
GCTTTCCAGAAACCGATGAAAGACGGAATTCAACTTCTGAACACCATTCAGGACGTATATCTGGATTCTTCAATAACCAT
TGCATAAAGAAGAAGTATCC

Downstream 100 bases:

>100_bases
AAATCTGTCTATCAAGCAGATGCTTTTTTTTAAGTTTTAATTATTAACTTTTAAAGAGGAGGTAAAAATGGTACCTGTAA
AAACAAACCAGAATTGGTTA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM 1; PGAM 1; Phosphoglyceromutase 1; dPGM 1

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKRIVLLRHGESLWNKENRFTGWTDVDLSEKGVEEACKAGDALREAGFSFEAAYTSYLKRAVKTLNCVLDRLDKDWIPVE
KTWRLNEKHYGMLQGLNKSETAVQYGEEQVHIWRRSYDVAPAPVGKDDPRNPGMDIRYAGVPDSELPRTESLKDTIGRVM
PYWKCIIFPALMYKDSLLVVAHGNSLRGIIKHLKGISDTDISNLNLPTAVPYVFEFDDRLVLVKDYYLGNPEEIRKRAEA
VAKQGMAKK

Sequences:

>Translated_249_residues
MKRIVLLRHGESLWNKENRFTGWTDVDLSEKGVEEACKAGDALREAGFSFEAAYTSYLKRAVKTLNCVLDRLDKDWIPVE
KTWRLNEKHYGMLQGLNKSETAVQYGEEQVHIWRRSYDVAPAPVGKDDPRNPGMDIRYAGVPDSELPRTESLKDTIGRVM
PYWKCIIFPALMYKDSLLVVAHGNSLRGIIKHLKGISDTDISNLNLPTAVPYVFEFDDRLVLVKDYYLGNPEEIRKRAEA
VAKQGMAKK
>Mature_249_residues
MKRIVLLRHGESLWNKENRFTGWTDVDLSEKGVEEACKAGDALREAGFSFEAAYTSYLKRAVKTLNCVLDRLDKDWIPVE
KTWRLNEKHYGMLQGLNKSETAVQYGEEQVHIWRRSYDVAPAPVGKDDPRNPGMDIRYAGVPDSELPRTESLKDTIGRVM
PYWKCIIFPALMYKDSLLVVAHGNSLRGIIKHLKGISDTDISNLNLPTAVPYVFEFDDRLVLVKDYYLGNPEEIRKRAEA
VAKQGMAKK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=249, Percent_Identity=53.0120481927711, Blast_Score=272, Evalue=2e-73,
Organism=Homo sapiens, GI4505753, Length=250, Percent_Identity=54.8, Blast_Score=265, Evalue=3e-71,
Organism=Homo sapiens, GI71274132, Length=250, Percent_Identity=52.4, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI4502445, Length=252, Percent_Identity=45.2380952380952, Blast_Score=237, Evalue=6e-63,
Organism=Homo sapiens, GI40353764, Length=252, Percent_Identity=45.2380952380952, Blast_Score=237, Evalue=6e-63,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=57.7639751552795, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1786970, Length=248, Percent_Identity=58.0645161290323, Blast_Score=291, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6322697, Length=245, Percent_Identity=48.5714285714286, Blast_Score=241, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6320183, Length=304, Percent_Identity=32.8947368421053, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324516, Length=295, Percent_Identity=29.4915254237288, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646216, Length=250, Percent_Identity=51.6, Blast_Score=254, Evalue=4e-68,
Organism=Drosophila melanogaster, GI85725270, Length=250, Percent_Identity=51.2, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI85725272, Length=250, Percent_Identity=51.2, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24650981, Length=250, Percent_Identity=51.2, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI28571817, Length=252, Percent_Identity=38.8888888888889, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28571815, Length=252, Percent_Identity=38.8888888888889, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24648979, Length=252, Percent_Identity=38.8888888888889, Blast_Score=175, Evalue=2e-44,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA1_BACTN (Q8A8R2)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_810018.1
- ProteinModelPortal:   Q8A8R2
- SMR:   Q8A8R2
- GeneID:   1073267
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_1105
- NMPDR:   fig|226186.1.peg.1105
- HOGENOM:   HBG658938
- OMA:   SDAAIME
- PhylomeDB:   Q8A8R2
- ProtClustDB:   PRK14115
- BioCyc:   BTHE226186:BT_1105-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28420; Mature: 28420

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIVLLRHGESLWNKENRFTGWTDVDLSEKGVEEACKAGDALREAGFSFEAAYTSYLKR
CCEEEEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AVKTLNCVLDRLDKDWIPVEKTWRLNEKHYGMLQGLNKSETAVQYGEEQVHIWRRSYDVA
HHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCC
PAPVGKDDPRNPGMDIRYAGVPDSELPRTESLKDTIGRVMPYWKCIIFPALMYKDSLLVV
CCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AHGNSLRGIIKHLKGISDTDISNLNLPTAVPYVFEFDDRLVLVKDYYLGNPEEIRKRAEA
ECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
VAKQGMAKK
HHHCCCCCC
>Mature Secondary Structure
MKRIVLLRHGESLWNKENRFTGWTDVDLSEKGVEEACKAGDALREAGFSFEAAYTSYLKR
CCEEEEEECCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AVKTLNCVLDRLDKDWIPVEKTWRLNEKHYGMLQGLNKSETAVQYGEEQVHIWRRSYDVA
HHHHHHHHHHHHCCCCCCCCHHEECCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCCC
PAPVGKDDPRNPGMDIRYAGVPDSELPRTESLKDTIGRVMPYWKCIIFPALMYKDSLLVV
CCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
AHGNSLRGIIKHLKGISDTDISNLNLPTAVPYVFEFDDRLVLVKDYYLGNPEEIRKRAEA
ECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
VAKQGMAKK
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928