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The map label for this gene is yjjG [H]

Identifier: 29144832

GI number: 29144832

Start: 4752605

End: 4753285

Strand: Direct

Name: yjjG [H]

Synonym: t4602

Alternate gene names: 29144832

Gene position: 4752605-4753285 (Clockwise)

Preceding gene: 29144831

Following gene: 29144833

Centisome position: 99.18

GC content: 53.3

Gene sequence:

>681_bases
ATGATGAAGTGGGACTGGATTTTCTTTGATGCCGATGAAACGCTGTTTACGTTTGATTCTTTCACCGGCTTACAGCGGAT
GTTCCTTGACTATAGCGTCACCTTTACCGCTGAGGATTTCCAGGATTACCAGGCCGTGAATAAGCCGCTATGGGTGGATT
ATCAGAACGGCGCGATTACTTCATTACAATTGCAGCACGCGCGCTTTCAAAGTTGGGCTGAACGGCTAAACGTTGCGCCG
GGGCGGCTGAATGACGCTTTTATTAGTGCGATGGCGGAGATCTGTTCTCCTTTGCCGGGCGCCGTTTCGCTACTTAATGC
GATTCGCGGGCAGGCTAAAATCGGTATTATTACTAACGGTTTTACCGCGCTACAACAAACTCGTCTGGAGCGCACCGGGC
TGCGCGAGTATTTCGATCTGCTGGTGATTTCCGAGCAGGTTGGCGTCGCGAAGCCCGATCCGAAAATCTTTAACTACGCC
CTGGAGCAGGCGGGGAATCCTGACCGCTCGCGCGTATTAATGGTTAGCGATACCGCGGAGTCCGATATTCTTGGCGGCAT
TAACGCCGGACTGTCGACCTGCTGGCTTAACGCGCATCATCGCGAGCAGCCCGCGGGTATCCATCCAACCTGGACTGTGG
CGTCATTAAGCGAACTGGAGCAGCTCCTGTGTAAACACTGA

Upstream 100 bases:

>100_bases
GGCGACGATTCGCCGCAATTACTATCCCACGGCACAAGGGCATGAGGACGCCATCATCATGGCGTTACCGATAAGCATGT
AATAAAAGAGGCAAGGTGTA

Downstream 100 bases:

>100_bases
TTGCCTCCCCCAGGTTGATGGGTAAAATAGCCGCATTTTTCGTATTCAACATGCGTGGTCAAACGCCGCGCTTACTCAAG
AAGATTTGACTATGACGTTG

Product: nucleotidase

Products: NA

Alternate protein names: House-cleaning nucleotidase; Non-canonical pyrimidine nucleotide phosphatase; Nucleoside 5'-monophosphate phosphohydrolase; dUMP phosphatase [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MMKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHARFQSWAERLNVAP
GRLNDAFISAMAEICSPLPGAVSLLNAIRGQAKIGIITNGFTALQQTRLERTGLREYFDLLVISEQVGVAKPDPKIFNYA
LEQAGNPDRSRVLMVSDTAESDILGGINAGLSTCWLNAHHREQPAGIHPTWTVASLSELEQLLCKH

Sequences:

>Translated_226_residues
MMKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHARFQSWAERLNVAP
GRLNDAFISAMAEICSPLPGAVSLLNAIRGQAKIGIITNGFTALQQTRLERTGLREYFDLLVISEQVGVAKPDPKIFNYA
LEQAGNPDRSRVLMVSDTAESDILGGINAGLSTCWLNAHHREQPAGIHPTWTVASLSELEQLLCKH
>Mature_226_residues
MMKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHARFQSWAERLNVAP
GRLNDAFISAMAEICSPLPGAVSLLNAIRGQAKIGIITNGFTALQQTRLERTGLREYFDLLVISEQVGVAKPDPKIFNYA
LEQAGNPDRSRVLMVSDTAESDILGGINAGLSTCWLNAHHREQPAGIHPTWTVASLSELEQLLCKH

Specific function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconat

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. YjjG family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=245, Percent_Identity=29.3877551020408, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790833, Length=225, Percent_Identity=90.6666666666667, Blast_Score=434, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR011951 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 25360; Mature: 25360

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAIT
CCEEEEEEEECCCCEEEHHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEEECCCCEE
SLQLQHARFQSWAERLNVAPGRLNDAFISAMAEICSPLPGAVSLLNAIRGQAKIGIITNG
EEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECC
FTALQQTRLERTGLREYFDLLVISEQVGVAKPDPKIFNYALEQAGNPDRSRVLMVSDTAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC
SDILGGINAGLSTCWLNAHHREQPAGIHPTWTVASLSELEQLLCKH
CHHHCCHHCCHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAIT
CCEEEEEEEECCCCEEEHHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEEECCCCEE
SLQLQHARFQSWAERLNVAPGRLNDAFISAMAEICSPLPGAVSLLNAIRGQAKIGIITNG
EEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECC
FTALQQTRLERTGLREYFDLLVISEQVGVAKPDPKIFNYALEQAGNPDRSRVLMVSDTAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCC
SDILGGINAGLSTCWLNAHHREQPAGIHPTWTVASLSELEQLLCKH
CHHHCCHHCCHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]