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The map label for this gene is cysQ [H]

Identifier: 29144702

GI number: 29144702

Start: 4603045

End: 4603785

Strand: Direct

Name: cysQ [H]

Synonym: t4457

Alternate gene names: 29144702

Gene position: 4603045-4603785 (Clockwise)

Preceding gene: 29144700

Following gene: 29144704

Centisome position: 96.06

GC content: 56.82

Gene sequence:

>741_bases
ATGTTAGAACAAGTATGCCAGCTTGCACGGAACGCGGGCGATGCCATTATGCAGGTTTATGATGGAGCCAAACCGATGGA
GTACGCCCGCAAGCAGGACGATTCTCCAGTCACTGCGGCGGATATCGCCGCACATACCGTGATTCTCGAAGGGTTACGCA
CGCTCACGCCGGATATTCCGGTGCTTTCAGAAGAAGATCCGCCCGCCTGGGAAGTGCGCCAGCACTGGCAGCGTTACTGG
CTGGTCGATCCGCTCGACGGCACCAAAGAATTCATCAAGCGCAATGGAGAATTCACGGTCAATATCGCGCTGATTGAGCA
GGGCAAGCCGGTGTTGGGCGTTGTCTATGCGCCGGTGCTGAAAGTGATGTACTACGCGGCGGAAGGTAAGGCCTGGAAAG
AGGAGTGCGGGGTGCGTAAGCAGATTCAGGTGCGGGATGCCCGCCCGCCGCTGGTGGTGATTAGCCGTTCGCATACGGAT
GATGAACTCACCGAATATCTCCAACAGCTTGGCGAACATCAGACTACCTCTATTGGTTCCTCGCTGAAATTCTGTCTTGT
GGCGGAAGGACAGGCGCAGCTTTACCCCAGATTTGGGCCGACCAGCGTCTGGGATACTGCCGCAGGTCATGCCATTGCCG
TTGCAGCCGGGGCGCACGTTCACGACTGGCAGGGAAAAACGCTGGACTATACCCCTCGTGAATCGTTCCTTAACCCCGGC
TTCCGGGTGACTATTTACTGA

Upstream 100 bases:

>100_bases
TATTATCAAAACCGCTGACGGTATCACAGTTGGCGGAACCCTTAACGATCGGGTATAAGTAAAACAACGAGTTAACGCCC
CCGTCATAAAGAGGTGGAGA

Downstream 100 bases:

>100_bases
GGAGCTTATGCAGCAGGTCGACCACCTGCTGTACCTCTTGCTGGGTTAACGCGCCATCTTTCACCCATTGAACCCGACCG
TCTTTGTCAAGCACGATGAC

Product: adenosine-3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLEQVCQLARNAGDAIMQVYDGAKPMEYARKQDDSPVTAADIAAHTVILEGLRTLTPDIPVLSEEDPPAWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIEQGKPVLGVVYAPVLKVMYYAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHTD
DELTEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTSVWDTAAGHAIAVAAGAHVHDWQGKTLDYTPRESFLNPG
FRVTIY

Sequences:

>Translated_246_residues
MLEQVCQLARNAGDAIMQVYDGAKPMEYARKQDDSPVTAADIAAHTVILEGLRTLTPDIPVLSEEDPPAWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIEQGKPVLGVVYAPVLKVMYYAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHTD
DELTEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTSVWDTAAGHAIAVAAGAHVHDWQGKTLDYTPRESFLNPG
FRVTIY
>Mature_246_residues
MLEQVCQLARNAGDAIMQVYDGAKPMEYARKQDDSPVTAADIAAHTVILEGLRTLTPDIPVLSEEDPPAWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIEQGKPVLGVVYAPVLKVMYYAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHTD
DELTEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTSVWDTAAGHAIAVAAGAHVHDWQGKTLDYTPRESFLNPG
FRVTIY

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=240, Percent_Identity=28.75, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI221625487, Length=241, Percent_Identity=29.045643153527, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790659, Length=246, Percent_Identity=89.0243902439024, Blast_Score=436, Evalue=1e-124,
Organism=Escherichia coli, GI1788882, Length=234, Percent_Identity=28.6324786324786, Blast_Score=84, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=243, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71995897, Length=263, Percent_Identity=26.615969581749, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71995905, Length=262, Percent_Identity=26.3358778625954, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537869, Length=208, Percent_Identity=26.4423076923077, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320493, Length=245, Percent_Identity=24.4897959183673, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641722, Length=267, Percent_Identity=26.2172284644195, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357303, Length=241, Percent_Identity=27.3858921161826, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 27490; Mature: 27490

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQVCQLARNAGDAIMQVYDGAKPMEYARKQDDSPVTAADIAAHTVILEGLRTLTPDIP
CHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPAWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIEQGKPVLGVVYAPVL
CCCCCCCCHHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCEEHHHHHHHH
KVMYYAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHTDDELTEYLQQLGEHQTTSIGS
HHHHHHCCCCCHHHHCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTSVWDTAAGHAIAVAAGAHVHDWQGKTLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCHHHCCCCCEEEEECCCEEECCCCCCCCCCCHHHHCCCC
FRVTIY
EEEEEC
>Mature Secondary Structure
MLEQVCQLARNAGDAIMQVYDGAKPMEYARKQDDSPVTAADIAAHTVILEGLRTLTPDIP
CHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPAWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIEQGKPVLGVVYAPVL
CCCCCCCCHHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCEEHHHHHHHH
KVMYYAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHTDDELTEYLQQLGEHQTTSIGS
HHHHHHCCCCCHHHHCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTSVWDTAAGHAIAVAAGAHVHDWQGKTLDYTPRESFLNPG
CEEEEEEECCCCEECCCCCCCCHHHCCCCCEEEEECCCEEECCCCCCCCCCCHHHHCCCC
FRVTIY
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]