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The map label for this gene is adiC [H]

Identifier: 29144463

GI number: 29144463

Start: 4365929

End: 4367266

Strand: Reverse

Name: adiC [H]

Synonym: t4201

Alternate gene names: 29144463

Gene position: 4367266-4365929 (Counterclockwise)

Preceding gene: 29144464

Following gene: 29144462

Centisome position: 91.14

GC content: 56.43

Gene sequence:

>1338_bases
ATGTCTTCGGATGCTGATGCTCACAAAGTGGGCCTAATCCCCGTCACCTTAATGGTATCGGGGAATATTATGGGTTCAGG
GGTATTCTTACTCCCTGCCAACCTGGCGGCCACTGGCGGGATTGCAATCTACGGATGGCTGGTCACTATCATCGGCGCCC
TGGCGCTGTCGATGGTTTATGCCAAAATGTCGTCCTTAGATCCCAGTCCCGGCGGTTCTTATGCCTATGCACGCCGCTGC
TTCGGGCCGTTTTTGGGCTATCAAACGAACGTGCTGTACTGGCTGGCATGCTGGATCGGTAATATCGCGATGGTCGTTAT
CGGCGTCGGCTATCTGAGCTATTTCTTCCCGATTCTGAAAGATCCGCTGGTATTAACGCTTACCTGCGTCGCGGTGCTGT
GGATTTTTGTTCTGCTGAACATCGTCGGGCCGAAAATGATTACCCGCGTACAGGCCGTCGCCACCGTACTGGCGCTGGTG
CCTATCGTAGGGATTGCGGTCTTCGGCTGGTTCTGGTTTAAAGGCGAAACCTATATGGCGGCCTGGAACGTGAGCGGTAT
GAATACCTTCGGCGCGATTCAAAGCACGTTGAACGTCACGCTATGGTCATTCATCGGGGTAGAAAGCGCCTCCGTTGCGG
CCGGTGTGGTAAAAAACCCGAAACGCAACGTGCCTATCGCCACCATCGGCGGGGTACTGATCGCCGCCGTCTGCTATGTA
CTCTCCACAACGGCGATTATGGGGATGATCCCCAACGCGGCGCTCCGTGTGTCAGCATCGCCTTTCGGTGACGCGGCGCG
TATGGCGCTGGGCGATACCGCAGGGGCTATTGTTTCCTTCTGTGCGGCAGCGGGGTGCCTGGGCTCTCTCGGCGGCTGGA
CGCTGCTTGCCGGCCAAACCGCAAAAGCGGCGGCGGACGATGGTCTCTTCCCGCCGATCTTCGCGCGGGTTAATAAAGCC
GGTACGCCAGTGGCTGGGTTGCTTATCGTCGGCGTGCTGATGACTATCTTCCAGTTCAGCAGTATGTCGCCGAACGCCGC
GAAAGAGTTTGGTCTGGTCTCCTCCGTGTCGGTTATCTTCACCCTGGTGCCTTATCTTTACACCTGTGCCGCGCTGTTGC
TATTGGGCCACGGTCACTTTGGTAAAGCGCGCCCGCTGTATCTGCTGATTACCTTCGTCGCGTTTGTATATTGCATCTGG
GCGGTTATCGGTTCCGGCGCCAAAGAAGTGATGTGGTCGTTCGTCACGTTGATGGTGATCACCGCGCTGTATGCGTTGAA
CTACAACCGCATTCACAAAAACCCGTATCCGCTGGATGCGCCGGTTAAACAAGATTGA

Upstream 100 bases:

>100_bases
TTGGCGATAACCCGTCTCCGATATAATTCAGCGGCATTCTGAGGGGGTATGATACGACGTAATTTATCGTAACGAAGTCA
CCTTTTCAGGAGTCCAAATT

Downstream 100 bases:

>100_bases
CCACGTGTAGTTAATGTTATCGCAACAGGCCGGATAGCGCAGGTTATCCGGCCACCACCAACATTAAGTTCTTAAGGTTC
ACTTAATTTTACTTTGTCAC

Product: arginine:agmatin antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALV
PIVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIW
AVIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD

Sequences:

>Translated_445_residues
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRC
FGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALV
PIVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKA
GTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIW
AVIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD
>Mature_444_residues
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVYAKMSSLDPSPGGSYAYARRCF
GPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILKDPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALVP
IVGIAVFGWFWFKGETYMAAWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYVL
STTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQTAKAAADDGLFPPIFARVNKAG
TPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIFTLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIWA
VIGSGAKEVMWSFVTLMVITALYALNYNRIHKNPYPLDAPVKQD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=342, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI115648022, Length=342, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI186910308, Length=354, Percent_Identity=24.0112994350282, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI186910306, Length=354, Percent_Identity=24.0112994350282, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI186910304, Length=354, Percent_Identity=24.0112994350282, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=94.1573033707865, Blast_Score=846, Evalue=0.0,
Organism=Escherichia coli, GI1790575, Length=441, Percent_Identity=39.0022675736961, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786908, Length=441, Percent_Identity=33.3333333333333, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1787890, Length=427, Percent_Identity=29.2740046838407, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082250, Length=353, Percent_Identity=28.8951841359773, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=23.9024390243902, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790653, Length=393, Percent_Identity=23.6641221374046, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786789, Length=370, Percent_Identity=21.6216216216216, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786302, Length=399, Percent_Identity=22.5563909774436, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994972, Length=379, Percent_Identity=24.2744063324538, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=413, Percent_Identity=25.4237288135593, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71995382, Length=413, Percent_Identity=25.4237288135593, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993915, Length=401, Percent_Identity=24.6882793017456, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=333, Percent_Identity=25.2252252252252, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71982612, Length=406, Percent_Identity=24.1379310344828, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982608, Length=405, Percent_Identity=23.9506172839506, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=356, Percent_Identity=26.9662921348315, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=312, Percent_Identity=22.1153846153846, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331183, Length=452, Percent_Identity=25.4424778761062, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647653, Length=452, Percent_Identity=25.4424778761062, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664379, Length=452, Percent_Identity=25.4424778761062, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24651635, Length=346, Percent_Identity=24.2774566473988, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24651633, Length=346, Percent_Identity=24.2774566473988, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641993, Length=386, Percent_Identity=24.6113989637306, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641995, Length=386, Percent_Identity=24.6113989637306, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46933; Mature: 46802

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVY
CCCCCCCCEECCEEEEEEEECCEEECCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHH
AKMSSLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALVPIVGIAVFGWFWFKGETYMA
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCC
AKAAADDGLFPPIFARVNKAGTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIWAVIGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TALYALNYNRIHKNPYPLDAPVKQD
HHHHHHCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLAATGGIAIYGWLVTIIGALALSMVY
CCCCCCCEECCEEEEEEEECCEEECCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHH
AKMSSLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
HHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVLTLTCVAVLWIFVLLNIVGPKMITRVQAVATVLALVPIVGIAVFGWFWFKGETYMA
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AWNVSGMNTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
EEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCC
AKAAADDGLFPPIFARVNKAGTPVAGLLIVGVLMTIFQFSSMSPNAAKEFGLVSSVSVIF
HHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TLVPYLYTCAALLLLGHGHFGKARPLYLLITFVAFVYCIWAVIGSGAKEVMWSFVTLMVI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TALYALNYNRIHKNPYPLDAPVKQD
HHHHHHCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]