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The map label for this gene is tyrB [H]

Identifier: 29144416

GI number: 29144416

Start: 4299077

End: 4300270

Strand: Direct

Name: tyrB [H]

Synonym: t4154

Alternate gene names: 29144416

Gene position: 4299077-4300270 (Clockwise)

Preceding gene: 29144415

Following gene: 29144417

Centisome position: 89.71

GC content: 55.44

Gene sequence:

>1194_bases
GTGTTTCAAAAAGTTGACGCCTATGCCGGCGATCCGATTCTTTCACTGATGGAGCGTTTTAAAGACGACTCCCGTCACGA
CAAAGTAAATCTGAACATTGGCCTGTATTACAACGAAGACGGGATTATCCCACAGCTCAAAACGGTGGCCGAAGCCGAAG
CCCGGCTTAACGCGCAGCCGCATGGCGCCTCGCTGTACCTGCCGATGGAAGGACTCAATACTTATCGCCATACTATCGCG
CCTTTGCTCTTTGGCGCCGATCACCCGGTTCTTCAGCAACAGCGCGTGGCCACTATCCAGACATTAGGTGGTTCAGGCGC
GCTGAAAGTGGGCGCGGATTTTCTGAAGCGTTATTTCCCCGACGCAGGCGTATGGGTGAGCGACCCTACCTGGGAAAACC
ATATTGCGATATTTGCCGGGGCAGGATTCGAAGTGAGTACTTACCCCTGGTATGACGACGCGACTAACGGCATCCGTTTT
AACGATCTGCTGGCCACGCTGAATACGTTACCTGCGCGCAGTATCGTGCTGCTGCACCCCTGTTGTCACAACCCGACCGG
GGCGGATTTAACGCCTTCGCAATGGGATGCGGTGATTGAGATAGTGAAAGCGCGCGATCTGATTCCGTTCCTTGATATTG
CCTATCAGGGGTTTGGCGCAGGCATGGACGAGGATGCTTACGCTATTCGCGCCATTGCCAGCGCCGGGTTACCTGCGTTA
GTCAGTAATTCTTTTTCGAAGATTTTCTCGCTGTATGGCGAGTGCGTCGGCGGCCTGTCGGTGGTGTGTGAAGATGCCGA
AATCGCCGCGCGGGTTCTGGGACAGCTAAAAGCGACGGTGCGCCGAATTTACTCCAGTCCGCCGTGTTTCGGCGCTCAGG
TGGTCGCTACGGTCCTGGGCGATGAGGCGTTAAAAGCGAGCTGGCTGGCGGAAGTCGACGCGATGCGTACCCGCATTATA
TCGATGCGCCAGACGCTGGTGAAAGAGCTGAAGGCGGAGATGCCTGACCGCAACTTCGATTACTTGTTACAGCAGCGTGG
TATGTTCAGCTATACCGGGTTAAGCGCGGAGCAGGTCGATCGGTTGCGCGATGAGTTTGGCGTTTACCTGATTGCCAGTG
GCCGCATGTGTGTCGCTGGGCTTAATGCTTCAAATGTACACCGCGTGGCGAAGGCATTTGCCGCTGTCATGTAA

Upstream 100 bases:

>100_bases
TCCGGTAATATGCGCATCCACCACAACATCCTCTCGATCTTCTCGTCCTTCCGGTTTATTGTGTTATTTCCTGCCCTCTG
TAAACCTGGAGAACCATCGC

Downstream 100 bases:

>100_bases
TATTCAGGCCGGACGGCGATAACAGTGCTCTCCGGTCTGACAATAGCTGTTGTGATCATCCTCTTTTTTCGTAACAAAAC
CGCAAATAATCCTTCCTTTT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLNIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
VSNSFSKIFSLYGECVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII
SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSAEQVDRLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM

Sequences:

>Translated_397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLNIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
VSNSFSKIFSLYGECVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII
SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSAEQVDRLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
>Mature_397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLNIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
VSNSFSKIFSLYGECVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII
SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSAEQVDRLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=42.0103092783505, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI4504067, Length=390, Percent_Identity=40.5128205128205, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=25.9842519685039, Blast_Score=158, Evalue=9e-39,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=88.9168765743073, Blast_Score=737, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=42.5692695214106, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=38.3838383838384, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI25147133, Length=390, Percent_Identity=41.025641025641, Blast_Score=301, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI17569539, Length=393, Percent_Identity=38.4223918575064, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=31.5384615384615, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.7414448669202, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25147136, Length=206, Percent_Identity=37.8640776699029, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=36.5432098765432, Blast_Score=280, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=34.1981132075472, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=39.2764857881137, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=39.2764857881137, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=38.2871536523929, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=38.2871536523929, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.659793814433, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43446; Mature: 43446

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLNIGLYYNEDGIIPQLKTVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP
CCCCEECCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
VSNSFSKIFSLYGECVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG
HHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DEALKASWLAEVDAMRTRIISMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSAEQVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLNIGLYYNEDGIIPQLKTVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP
CCCCEECCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
VSNSFSKIFSLYGECVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG
HHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DEALKASWLAEVDAMRTRIISMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSAEQVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8809108; 11677609 [H]