Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 29144273

GI number: 29144273

Start: 4155629

End: 4156981

Strand: Direct

Name: envZ [H]

Synonym: t4005

Alternate gene names: 29144273

Gene position: 4155629-4156981 (Clockwise)

Preceding gene: 29144272

Following gene: 29144275

Centisome position: 86.72

GC content: 57.43

Gene sequence:

>1353_bases
ATGAGGCGAATGCGCTTCTCGCCGCGAAGTTCATTTGCCCGCACGCTGTTGCTCATCGTCACCTTGCTGTTCGTCAGCCT
GGTGACGACCTACCTGGTGGTGCTGAACTTCGCGATTTTGCCGAGCCTCCAGCAGTTTAATAAGGTTCTGGCTTACGAAG
TCCGTATGCTGATGACCGATAAGCTGCAACTGGAGGACGGCACGCAGTTAGTCGTGCCGCCTGCGTTTCGCCGGGAAATC
TATCGCGAGCTGGGGATCTCTCTCTACACCAACGAAGCCGCTGAAGAGGCCGGGCTGCGTTGGGCGCAACACTACGAATT
CTTAAGCCACCAGATGGCGCAGCAATTAGGCGGCCCGACGGAAGTGCGGGTTGAGGTCAACAAAAGCTCGCCCGTCGTGT
GGCTCAAAACCTGGCTGTCGCCCAATATCTGGGTGCGCGTGCCGCTGACCGAGATTCATCAGGGCGATTTTTCTCCGCTT
TTCCGTTACACGCTGGCGATCATGCTCCTGGCGATAGGCGGCGCGTGGCTGTTTATTCGTATACAGAACAGACCGTTAGT
GGATCTTGAACATGCCGCCTTGCAGGTAGGGAAGGGAATTATTCCGCCGCCGCTGCGTGAATATGGCGCCTCTGAGGTGC
GCTCTGTGACCCGGGCGTTTAACCATATGGCAGCCGGCGTGAAACAATTGGCCGATGACCGTACGCTATTGATGGCGGGC
GTCAGCCACGACTTACGCACGCCGCTGACCCGTATTCGTCTGGCGACGGAGATGATGGGCGAGGAAGACGGTTATCTCGC
GGAGTCGATCAATAAAGACATCGAAGAGTGTAACGCCATTATCGAACAGTTTATTGACTATCTGCGTACCGGTCAGGAAA
TGCCAATGGAGATGGCGGATCTCAATTCCGTGCTGGGCGAGGTGATTGCGGCGGAAAGCGGCTATGAGCGTGAGATTAAC
ACTGCGCTTCAGGCAGGCAGCATCCAGGTGAAAATGCACCCGCTCTCGATTAAGCGCGCGGTGGCGAATATGGTGGTCAA
TGCTGCCCGCTATGGCAACTGCTGGATTAAGGTCAGCAGCGGCACCGAGTCGCATCGCGCCTGGTTCCAGGTAGAAGATG
ACGGGCCGGGCATTAAGCCGGAGCAGCGTAAACATCTGTTCCAGCCTTTTGTGCGCGGCGACAGCGCCCGTAGCACCAGC
GGCACAGGGCTGGGGCTGGCGATTGTGCAGCGCATTATTGATAACCATAACGGGATGCTGGAGATTGGCACCAGCGAGCG
TGGCGGATTGTCGATTCGCGCCTGGCTACCGGTTCCTGTGGCTCGCGTCCAGGGGACGACAAAAGAGGCATAA

Upstream 100 bases:

>100_bases
CCCGCCTGCGCCGTATGGTGGAAGAAGATCCGGCGCATCCGCGTTATATTCAGACCGTATGGGGCCTGGGCTACGTCTTC
GTACCGGACGGTTCTAAAGC

Downstream 100 bases:

>100_bases
GAAAGGGAGGTATTACCCTCCCTTTCTTCTTAACACTGGATGACGCTGTTCAAAGCCGCCATCCGGCCTGTTCCTTACAG
CTTCGGTCCGGCGCTAACCA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYTNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNSVLGEVIAAESGYEREIN
TALQAGSIQVKMHPLSIKRAVANMVVNAARYGNCWIKVSSGTESHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS
GTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVPVARVQGTTKEA

Sequences:

>Translated_450_residues
MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYTNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNSVLGEVIAAESGYEREIN
TALQAGSIQVKMHPLSIKRAVANMVVNAARYGNCWIKVSSGTESHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS
GTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVPVARVQGTTKEA
>Mature_450_residues
MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDKLQLEDGTQLVVPPAFRREI
YRELGISLYTNEAAEEAGLRWAQHYEFLSHQMAQQLGGPTEVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAIGGAWLFIRIQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNSVLGEVIAAESGYEREIN
TALQAGSIQVKMHPLSIKRAVANMVVNAARYGNCWIKVSSGTESHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTS
GTGLGLAIVQRIIDNHNGMLEIGTSERGGLSIRAWLPVPVARVQGTTKEA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=450, Percent_Identity=95.3333333333333, Blast_Score=885, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=33.4600760456274, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=31.0861423220974, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=32.2429906542056, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=25.2293577981651, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=273, Percent_Identity=27.4725274725275, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786783, Length=277, Percent_Identity=26.7148014440433, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=24.0549828178694, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=27.3972602739726, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789403, Length=250, Percent_Identity=26.8, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=210, Percent_Identity=30, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787374, Length=226, Percent_Identity=24.3362831858407, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=25.7692307692308, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50421; Mature: 50421

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
KLQLEDGTQLVVPPAFRREIYRELGISLYTNEAAEEAGLRWAQHYEFLSHQMAQQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNSVLGEVIAAESGYEREINTALQAGSIQVKMHPLSIKRAVANMVVNAARYGNCWIKVSS
HHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECC
GTESHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGML
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
EIGTSERGGLSIRAWLPVPVARVQGTTKEA
EECCCCCCCEEEEEECCCCHHHHCCCCCCC
>Mature Secondary Structure
MRRMRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
KLQLEDGTQLVVPPAFRREIYRELGISLYTNEAAEEAGLRWAQHYEFLSHQMAQQLGGPT
CEEECCCCEEEECHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EVRVEVNKSSPVVWLKTWLSPNIWVRVPLTEIHQGDFSPLFRYTLAIMLLAIGGAWLFIR
EEEEEECCCCCEEEEEECCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVDLEHAALQVGKGIIPPPLREYGASEVRSVTRAFNHMAAGVKQLADDRTLLMAG
ECCCCCCHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
VSHDLRTPLTRIRLATEMMGEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMAD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
LNSVLGEVIAAESGYEREINTALQAGSIQVKMHPLSIKRAVANMVVNAARYGNCWIKVSS
HHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECC
GTESHRAWFQVEDDGPGIKPEQRKHLFQPFVRGDSARSTSGTGLGLAIVQRIIDNHNGML
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEE
EIGTSERGGLSIRAWLPVPVARVQGTTKEA
EECCCCCCCEEEEEECCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]