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The map label for this gene is ggt [H]

Identifier: 29144238

GI number: 29144238

Start: 4108119

End: 4109861

Strand: Direct

Name: ggt [H]

Synonym: t3970

Alternate gene names: 29144238

Gene position: 4108119-4109861 (Clockwise)

Preceding gene: 29144236

Following gene: 29144244

Centisome position: 85.73

GC content: 55.31

Gene sequence:

>1743_bases
ATGAAACCAACGTTTATGCGCTGGGTGGCGATCGCCGCTCTGCTGGCCGGGGGGACGTTTAGCGCGGTGGCCAATCCTCC
CGTCGCGCCGCCAGTCTCCTATGGTGTTGAAGAAGATGTCTTTCATCCTGTACGGGCGACGCAAGGGATGGTGGCGTCCG
TGGATGCAATGGCGACGCAGGTTGGCGTGGATATCTTAAAGCAGGGCGGTAATGCCGTGGATGCCGCCGTCGCCGTGGGC
TATGCGCTGGCTGTCACGCATCCGCAAGCCGGGAATCTGGGCGGCGGGGGATTTATGCTGCTGCGCACTAAAGATGGCGC
TACCACGGCGATCGATTTTCGTGAAATGGCGCCGGCTGCCGCGACCCGTGATATGTTCCTCGACGATCAGGGTAACGCCG
ATGCGAAAAAGTCGCTGACGTCGCATCTGGCATCCGGTACGCCGGGTACCGTGGCGGGTTTCTCGCTGGCGCTGGAGAAA
TACGGCACGATGCCGCTGAATAAAGTGGTGCGTCCGGCGATGAAGCTGGCGGAAGAGGGTTTTGTGGTTAACGATGCGCT
GGCCGACGACTTAAAAACTTACGGCAGCGAAGTGATCCCCAACCATGAGAACAGCAAAGCCATTTTCTGGAAAGACGGCG
AGCCGCTGAAAAAAGGCGATAAGCTGATCCAGAAGAATCTGGCGAAAAGCCTGGAAATGATTGCCGAAAACGGCCCGGCT
GCGTTTTATAAAGGGGCGATTGCCGACCAGATTGCCGGGGAAATGCAGAAGAACGGCGGTCTGATGACCAAAGAGGATTT
AGCCAGCTATAAAGCCGTTGAGCGTACGCCAATCAGCGGTGACTATCGCGGGTATCAGGTTTTCTCCATGCCGCCGCCGT
CCTCGGGCGGTATTCACATCGTGCAAATCCTCAATATTCTTGAAAATTTCGACATGAAGAAGTACGGCTTTGGCAGCGCC
GATGCCATGCAAATCATGGCGGAAGCGGAAAAATACGCCTACGCTGACCGCTCAGAGTATCTGGGCGATCCGGACTTTGT
GAAAGTGCCGTGGCAGGCGCTGACCAACAAAGCCTATGCGAAAACGTTGGCCGATCAAATAGATATTAATAAGGCAAAAC
CTTCCAGCCAGATCAAACCGGGCAAGCTCGCCCCGTATGAAAGCAACCAGACCACCCACTTCTCGGTGGTGGATAAAGAC
GGCAATGCTGTGGCGGTGACCTATACCCTGAACACCACCTTCGGCACAGGAATTGTGGCGGGAAATACCGGTATTCTGCT
GAATAATCAAATGGATGATTTTTCTGCTAAGCCTGGTGTACCCAATGTTTATGGCCTAGTGGGCGGCGATGCTAACGCGG
TCGAACCAAAAAAACGTCCGCTGTCGTCGATGTCGCCGACTATCGTGGTAAAAGACGGCAAAACCTGGCTGGTGACCGGT
AGCCCTGGCGGGAGTCGAATCATCACTACTGTGCTGCAAATGGTAGTGAACAGCATTGATTTTGGCATGAACGTCGCCGA
AGCGACCAACGCGCCGCGTTTCCATCATCAATGGTTGCCGGACGAACTGCGGGTAGAAAAGGGCTTCAGCCCCGATACGC
TGAAGTTGCTGGAACAGAAAGGGCAGAAAGTCGCGCTGAAAGAAGCGATGGGCAGCACCCAAAGTATTATGGTTGGACCG
GATGGCGAACTGTACGGTGCGTCTGACCCGCGTTCCGTGGATGATTTAACGGCGGGATACTGA

Upstream 100 bases:

>100_bases
TTTTTAAGTGTACCTCTATTTCGCCATGATGATGATTTTTTAAGCGTTGTGGACCAGGATTAAACGGGACATACACCCCT
TTATCTGGAGAAAAACAACG

Downstream 100 bases:

>100_bases
TTTTTAATTCCAGGCCCGGTGTCAGACACCGGGCTATTTGCAGATTATGCCGTGAGTAATCGGGCTGGATTATCAATACA
AAGCTTGCGCAGAGTATCGT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAAATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALADDLKTYGSEVIPNHENSKAIFWKDGEPLKKGDKLIQKNLAKSLEMIAENGPA
AFYKGAIADQIAGEMQKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Sequences:

>Translated_580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAAATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALADDLKTYGSEVIPNHENSKAIFWKDGEPLKKGDKLIQKNLAKSLEMIAENGPA
AFYKGAIADQIAGEMQKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY
>Mature_580_residues
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQVGVDILKQGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAAATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEK
YGTMPLNKVVRPAMKLAEEGFVVNDALADDLKTYGSEVIPNHENSKAIFWKDGEPLKKGDKLIQKNLAKSLEMIAENGPA
AFYKGAIADQIAGEMQKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKD
GNAVAVTYTLNTTFGTGIVAGNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=534, Percent_Identity=32.5842696629214, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI73915090, Length=534, Percent_Identity=32.5842696629214, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI73915096, Length=534, Percent_Identity=32.5842696629214, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI73915094, Length=534, Percent_Identity=32.5842696629214, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI113429324, Length=534, Percent_Identity=31.2734082397004, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI113429326, Length=538, Percent_Identity=30.4832713754647, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.511839708561, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI153266901, Length=553, Percent_Identity=29.4755877034358, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI153266885, Length=554, Percent_Identity=29.0613718411552, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI153266907, Length=553, Percent_Identity=27.4864376130199, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=34.703196347032, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=34.703196347032, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=31.5068493150685, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=91.0344827586207, Blast_Score=1074, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=574, Percent_Identity=34.3205574912892, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI72000294, Length=574, Percent_Identity=34.3205574912892, Blast_Score=259, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17542894, Length=529, Percent_Identity=34.2155009451796, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI193208247, Length=555, Percent_Identity=32.2522522522522, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI193208245, Length=557, Percent_Identity=32.6750448833034, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=31.0592459605027, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.5395033860045, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI72001497, Length=223, Percent_Identity=27.3542600896861, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=223, Percent_Identity=27.3542600896861, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=492, Percent_Identity=31.3008130081301, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=32.8413284132841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=32.8413284132841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=32.8413284132841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=32.8413284132841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=32.8413284132841, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI161077496, Length=550, Percent_Identity=30.1818181818182, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.8880308880309, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI18859741, Length=552, Percent_Identity=28.6231884057971, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61698; Mature: 61698

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQ
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHCCHHHHHCCHHHHHHHHHHH
VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAA
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEHHHHCCHH
ATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVRPAMKLAEEG
HHHHHEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FVVNDALADDLKTYGSEVIPNHENSKAIFWKDGEPLKKGDKLIQKNLAKSLEMIAENGPA
CEEEHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
AFYKGAIADQIAGEMQKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
CCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MKPTFMRWVAIAALLAGGTFSAVANPPVAPPVSYGVEEDVFHPVRATQGMVASVDAMATQ
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCHHHCCHHHHHCCHHHHHHHHHHH
VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLLRTKDGATTAIDFREMAPAA
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCCEEEEHHHHCCHH
ATRDMFLDDQGNADAKKSLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVRPAMKLAEEG
HHHHHEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FVVNDALADDLKTYGSEVIPNHENSKAIFWKDGEPLKKGDKLIQKNLAKSLEMIAENGPA
CEEEHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
AFYKGAIADQIAGEMQKNGGLMTKEDLASYKAVERTPISGDYRGYQVFSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KTLADQIDINKAKPSSQIKPGKLAPYESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GNTGILLNNQMDDFSAKPGVPNVYGLVGGDANAVEPKKRPLSSMSPTIVVKDGKTWLVTG
CCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDFGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEQK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]