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The map label for this gene is prlC [H]

Identifier: 29144193

GI number: 29144193

Start: 4058831

End: 4060873

Strand: Direct

Name: prlC [H]

Synonym: t3922

Alternate gene names: 29144193

Gene position: 4058831-4060873 (Clockwise)

Preceding gene: 29144192

Following gene: 29144194

Centisome position: 84.7

GC content: 55.75

Gene sequence:

>2043_bases
ATGACCAATCCATTACTAACGTCTTTTTCACTGCCGCCTTTTTCTGCAATTAAACCGGAGCATGTGGTGCCTGCGGTCAC
CAAAGCGTTGGCCGATTGCCGGGCGGCGGTAGAAGGCGTTGTGGCGCATGGCGCGCCGTATAGCTGGGAAAACCTCTGCC
AGCCGTTGGCGGAAGCCGACGATGTTCTGGGGCGTATTTTCTCGCCAATTAGCCACTTAAACTCGGTGAAAAATAGCCCG
GAGCTGCGTGAAGCCTACGAACAGACGTTACCGCTGCTGTCGGAATACAGCACCTGGGTTGGGCAACATGAAGGACTGTA
CAACGCGTACCGCGACCTGCGCGACGGCGATCATTACGCCACTCTGAATACCGCGCAGAAGAAAGCGGTTGATAACGCGC
TGCGTGATTTTGAACTGTCCGGCATCGGCCTGCCGAAAGAGAAACAGCAGCGTTACGGTGAAATTGCCACCCGCCTGTCT
GAGCTGGGCAACCAGTACAGCAATAATGTGCTCGATGCCACCATGGGCTGGACGAAGCTCATCACCGACGAAGCCGAGCT
GGCGGGAATGCCGGAAAGCGCGCTCGCCGCCGCTAAAGCCCTGGCGGAAGCCAAAGAGCAGGAAGGTTACCTGCTGACTC
TGGATATCCCGAGCTATCTGCCAGTGATGACCTACTGCGACAACCAGGCGTTGCGTGAAGAGATGTATCGCGCCTATTCC
ACTCGTGCCTCCGATCAGGGGCCGAACGCCGGTAAGTGGGATAACAGCCCGGTGATGGAAGAAATTCTTGCGCTGCGCCA
TGAACTGGCGCAACTGCTGGGCTTCGAAAATTATGCCCATGAGTCACTGGCCACCAAGATGGCGGAAAATCCGCAGCAGG
TGCTCGATTTCTTAACCGATCTGGCGAAACGCGCCCGTCCGCAGGGGGAAAAAGAGCTGGCCCAGCTGCGCGCCTTCGCC
AAAGCCGAATTTGGCGTTGAGGAACTGCAACCATGGGATATCGCGTACTACAGTGAAAAGCAAAAACAGCACCTGTACAG
CATCAGCGATGAGCAGCTACGCCCGTACTTCCCGGAAAACAAAGCCGTGAACGGCCTGTTTGAAGTGGTGAAACGTATTT
ACGGCATCACCGCCAAAGAGCGTACTGATGTTGATGTCTGGCACCCGGAGGTGCGTTTCTTCGAACTGTATGACGAAAAT
AACGAGCTGCGCGGCAGCTTCTACCTTGACCTGTACGCGCGCGAACACAAACGCGGCGGGGCGTGGATGGACGACTGTGT
CGGCCAGATGCGTAAAGCGGATGGCACATTGCAAAAGCCGGTCGCTTATCTGACCTGTAATTTCAACCGTCCGGTGAACG
GTAAACCCGCTCTGTTTACCCATGACGAAGTGATCACCCTGTTCCACGAGTTTGGTCATGGCCTGCATCATATGCTGACC
CGCATTGAGACCGCCGGGGTCTCCGGTATCAGCGGCGTGCCGTGGGATGCGGTCGAACTGCCAAGTCAGTTTATGGAAAA
CTGGTGCTGGGAGCCAGAAGCGCTGGCGTTTATCTCCGGCCACTATGAGACCGGCGAACCGCTGCCGAAGGAACTGCTGG
ATAAAATGCTGGCGGCGAAAAACTATCAGGCGGCGCTGTTTATTCTGCGTCAGCTGGAGTTCGGTCTGTTTGATTTCCGT
CTGCATGCGGAATTTAACCCGCAGCAAGGAGCGAAAATTCTTGATACGCTCTTTGAAATTAAAAAACAGGTCGCCGTGGT
GCCGTCACCGACATGGGGCCGTTTCCCACATGCGTTCAGCCATATCTTTGCTGGCGGCTATGCGGCAGGCTACTACAGCT
ATCTGTGGGCCGACGTACTGGCGGCGGACGCTTATTCTCGCTTTGAGGAGGAAGGCATTTTCAACCGTGAGACCGGTCAG
TCGTTCCTTGATAACATCCTGACTCGCGGTGGTTCTGAAGAGCCGATGGAACTCTTTAAACGCTTCCGTGGCCGTGAACC
ACAGCTGGACGCGATGCTGGAGCATTACGGGATTAAAGGCTGA

Upstream 100 bases:

>100_bases
GCCCACCATCATTGAAATTCCCCCAACTATCCCCCATTCTAGATCCATAGCGAAAGCGCGATAGAGCGCTTCATTTCTTT
TTTAGACCAGGACTGCGCAT

Downstream 100 bases:

>100_bases
TTTTACGTGCAAATCTGCTTAATGGATGAAACGGGCGCCACAGACGGCGCCTTATCTGTTCTGGCTGCCCGCTGGGGACT
GGAGCATGACGAAGACAACC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 680; Mature: 679

Protein sequence:

>680_residues
MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKALAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEN
NELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFNPQQGAKILDTLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQ
SFLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

Sequences:

>Translated_680_residues
MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSP
ELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLS
ELGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKALAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFA
KAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDEN
NELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFR
LHAEFNPQQGAKILDTLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQ
SFLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG
>Mature_679_residues
TNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSPE
LREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSE
LGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKALAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYST
RASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAK
AEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENN
ELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTR
IETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRL
HAEFNPQQGAKILDTLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQS
FLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=640, Percent_Identity=30.78125, Blast_Score=312, Evalue=7e-85,
Organism=Homo sapiens, GI14149738, Length=674, Percent_Identity=29.8219584569733, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI156105687, Length=620, Percent_Identity=26.9354838709677, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=95.1470588235294, Blast_Score=1322, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=688, Percent_Identity=32.4127906976744, Blast_Score=328, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI71999758, Length=689, Percent_Identity=24.5283018867925, Blast_Score=158, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565901, Length=613, Percent_Identity=24.1435562805873, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319793, Length=701, Percent_Identity=29.243937232525, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6322715, Length=647, Percent_Identity=23.8021638330757, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21356111, Length=555, Percent_Identity=30.2702702702703, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI20129717, Length=589, Percent_Identity=26.1460101867572, Blast_Score=192, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76915; Mature: 76784

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEAD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPISHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHH
ITDEAELAGMPESALAAAKALAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENNELRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHCCCC
AWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFNPQQGAKILDTLFEIKKQVAVVPSPTWGRFPHAFS
CHHHHHHHHHHHHCCCEEEEEECCCCHHCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQSFLDNILTRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEAD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DVLGRIFSPISHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEE
TLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKL
EHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHH
ITDEAELAGMPESALAAAKALAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYS
HCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHH
TRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTD
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHH
LAKRARPQGEKELAQLRAFAKAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPEN
HHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCCC
KAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENNELRGSFYLDLYAREHKRGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHCCCC
AWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLT
CCHHHHHHHHHHCCCCHHCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAK
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHC
NYQAALFILRQLEFGLFDFRLHAEFNPQQGAKILDTLFEIKKQVAVVPSPTWGRFPHAFS
CHHHHHHHHHHHHCCCEEEEEECCCCHHCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
HIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQSFLDNILTRGGSEEPMELFK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
RFRGREPQLDAMLEHYGIKG
HHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]