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The map label for this gene is tdh [H]

Identifier: 29144091

GI number: 29144091

Start: 3930728

End: 3931753

Strand: Direct

Name: tdh [H]

Synonym: t3811

Alternate gene names: 29144091

Gene position: 3930728-3931753 (Clockwise)

Preceding gene: 29144090

Following gene: 29144092

Centisome position: 82.03

GC content: 53.51

Gene sequence:

>1026_bases
ATGAAAGCGTTATCCAAACTGAAAGCGGAAGAGGGCATCTGGATGACCGACGTTCCGGAACCGGAAGTCGGCCATAACGA
TTTGCTGATTAAAATCCGTAAAACAGCCATCTGCGGCACTGACGTTCACATCTATAACTGGGATGAATGGTCGCAAAAAA
CCATCCCGGTTCCGATGGTCGTGGGGCATGAATATGTCGGCGAAGTGGTCGGCATCGGTCAGGAAGTGAAAGGCTTTAAA
ATCGGCGATCGCGTCTCCGGCGAAGGTCACATCACTTGCGGTCATTGCCGCAACTGCCGTGGCGGTCGTACTCACCTGTG
TCGCAACACCACCGGCGTGGGCGTCAACCGTCCCGGCTGCTTCGCGGAATACCTGGTCATCCCGGCATTCAATGCGTTTA
AAATCCCGGATAACATTTCTGATGATTTAGCCTCTATTTTCGACCCGTTTGGTAATGCGGTGCATACGGCGCTGTCTTTC
GATCTGGTCGGCGAAGATGTACTGGTATCGGGGGCGGGGCCAATCGGCGTAATGGCCGCCGCGGTGGCGAAACATGTCGG
CGCGCGTCATGTGGTGATTACTGACGTCAATGAATACCGTCTGGAGCTGGCGCGCAAAATGGGCGTCACCCGCGCGGTCA
ACGTCGCGAAAGAGAGCCTGAACGACGTCATGGCGGAGCTGGGAATGACCGAAGGGTTTGATGTGGGTCTGGAGATGTCC
GGCGCGCCGCCGGCGTTTCGTACCATGCTGGACACCATGAATCACGGCGGTCGTATTGCGATGCTGGGGATTCCGCCATC
AGATATGTCTATCGACTGGACAAAAGTCATCTTTAAAGGCTTGTTCATTAAAGGTATTTATGGTCGTGAGATGTTCGAAA
CGTGGTACAAAATGGCGGCGCTGATCCAGTCCGGTCTGGATCTGTCACCGATTATCACCCATCGTTTCTCTGTTGATGAT
TTTCAGAAAGGTTTTGACGCCATGTGTTCAGGCCAGTCAGGAAAAGTCATTCTGAGCTGGGATTAA

Upstream 100 bases:

>100_bases
CCAGATGTCTGCGGCGCATACGCCTGAGCAAATTACGCGTGCGGTAGACGCGTTCACGCGTATTGGTAAACAACTGGGCG
TGATTGCCTGAGGATGTAAG

Downstream 100 bases:

>100_bases
TATGTATATACCCAAAATAATTCGAGTTGCTTAAAGGCGGCAAGGGAGTGAGTCCCCAGGAGCATAGATAACTATGTGAC
TGGGGTGAACGACAAATCTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSVDD
FQKGFDAMCSGQSGKVILSWD

Sequences:

>Translated_341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSVDD
FQKGFDAMCSGQSGKVILSWD
>Mature_341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSVDD
FQKGFDAMCSGQSGKVILSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=27.2455089820359, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=25.201072386059, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=26.9121813031161, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=26.9121813031161, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI34577061, Length=350, Percent_Identity=24.5714285714286, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501933, Length=376, Percent_Identity=23.6702127659574, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=24.0687679083095, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=23.9067055393586, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI71565154, Length=347, Percent_Identity=25.3602305475504, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=97.0674486803519, Blast_Score=686, Evalue=0.0,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=30.327868852459, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=28.8753799392097, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=29.559748427673, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=31.6860465116279, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=27.8787878787879, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI87081918, Length=284, Percent_Identity=30.9859154929577, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788407, Length=340, Percent_Identity=26.1764705882353, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=27.979274611399, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=26.0586319218241, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=27.6536312849162, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786518, Length=280, Percent_Identity=27.1428571428571, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=320, Percent_Identity=34.0625, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=31.7365269461078, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71988145, Length=233, Percent_Identity=32.1888412017167, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=127, Percent_Identity=35.4330708661417, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=273, Percent_Identity=26.7399267399267, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=25.668449197861, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=25.4010695187166, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=353, Percent_Identity=24.6458923512748, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=31.055900621118, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322619, Length=307, Percent_Identity=28.9902280130293, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319955, Length=307, Percent_Identity=28.6644951140065, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=373, Percent_Identity=26.8096514745308, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=361, Percent_Identity=27.4238227146814, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=358, Percent_Identity=27.0949720670391, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=279, Percent_Identity=31.1827956989247, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=279, Percent_Identity=31.5412186379928, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=28.6153846153846, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=270, Percent_Identity=28.1481481481481, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=30.2325581395349, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.3012048192771, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.1989389920424, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551930, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221457811, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550770, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37160; Mature: 37160

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGC
ECHHHHHHHHCCCCCCCCEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
HHHHHEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFSVDDFQKGFDAMCSGQSGKVILSWD
HHHCCCCCCHHHHEECCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGC
ECHHHHHHHHCCCCCCCCEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
HHHHHEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFSVDDFQKGFDAMCSGQSGKVILSWD
HHHCCCCCCHHHHEECCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA