The gene/protein map for NC_004631 is currently unavailable.
Definition Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome.
Accession NC_004631
Length 4,791,961

Click here to switch to the map view.

The map label for this gene is ccmA [H]

Identifier: 29143992

GI number: 29143992

Start: 3815625

End: 3816242

Strand: Direct

Name: ccmA [H]

Synonym: t3699

Alternate gene names: 29143992

Gene position: 3815625-3816242 (Clockwise)

Preceding gene: 29143991

Following gene: 29143993

Centisome position: 79.63

GC content: 72.82

Gene sequence:

>618_bases
ATGCTTGAAGCCAGAGATCTGTACTGCGAGCGGGACGAGAGGACGCTGTTTCGCGGGCTGTCGTTCACCGTGGAGGCCGG
GGAGTGGGTGCAGGTCACCGGCGGCAACGGCGCCGGAAAAACCACCCTGCTGCGCCTGCTGACCGGGCTGGCGCGCCCGG
ACGGCGGGGAGGTGTACTGGCAGGGCGAGCCCCTGCGCCGCGTGCGCGACAGCTTCCATCGCAGCCTGCTGTGGATAGGG
CACCAGCCGGGGATAAAAACCCGCCTGACGGCGCGGGAGAACCTGCACTTTTTCCACCCCGGTGACGGCGCGCGTCTCCC
GGAGGCGCTGGCGCAGGCCGGGCTGGCGGGATTTGAGGACGTGCCGGTCGCTCAGCTCTCGGCCGGGCAGCAGCGCCGGG
TGGCGCTGGCCCGCCTGTGGCTGACCCGCGCCGCGCTGTGGGTGCTCGACGAGCCGTTCACCGCCATTGACGTTAACGGC
GTGGCGCGCCTCACCCGGCGGATGGCGGCGCACACGGCGCAGGGCGGGATGGTCATCCTCACCACCCACCAGCCGCTGCC
GGGGGCCGCGGACACCGTCCGCCGCCTGGCGCTGACCGGCGGGGGGGCCGGGCTGTGA

Upstream 100 bases:

>100_bases
CCGATCTGCCGCAAAACGATATTGACGATATCGTCGCCTTCCTGGAAAGCCTGACCGGTGTTTATACGCCATATCAACCT
GAATATGCGCAATGACAATG

Downstream 100 bases:

>100_bases
TGTGGCGTGTCTTCTGTCTCGAGCTGCGCGTGGCGTTCCGCCACGGCGCGGACATCGCCGGCCCGCTGTGGTTCTTCCTG
ATGGTCATCACCCTGTTTCC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Cytochrome c biogenesis ATP-binding export protein CcmA 2; Heme exporter protein A 2; Cytochrome c-type biogenesis protein CcmE 2; Cytochrome c maturation protein E 2; Heme chaperone CcmE 2 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLEARDLYCERDERTLFRGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIG
HQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVAQLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNG
VARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGGAGL

Sequences:

>Translated_205_residues
MLEARDLYCERDERTLFRGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIG
HQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVAQLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNG
VARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGGAGL
>Mature_205_residues
MLEARDLYCERDERTLFRGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIG
HQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVAQLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNG
VARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGGAGL

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=212, Percent_Identity=30.6603773584906, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI153792144, Length=211, Percent_Identity=28.436018957346, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI11967969, Length=189, Percent_Identity=29.1005291005291, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI9665248, Length=210, Percent_Identity=28.0952380952381, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI255708477, Length=203, Percent_Identity=29.064039408867, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI148612844, Length=203, Percent_Identity=29.064039408867, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI27477115, Length=195, Percent_Identity=27.6923076923077, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI73747915, Length=164, Percent_Identity=28.6585365853659, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI73747917, Length=164, Percent_Identity=28.6585365853659, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI150417984, Length=199, Percent_Identity=30.1507537688442, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI42741659, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082064, Length=200, Percent_Identity=79.5, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI87081709, Length=166, Percent_Identity=32.5301204819277, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI87081791, Length=195, Percent_Identity=29.7435897435897, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1789891, Length=188, Percent_Identity=30.3191489361702, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789873, Length=200, Percent_Identity=28, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787370, Length=180, Percent_Identity=29.4444444444444, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1787112, Length=187, Percent_Identity=31.0160427807487, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788165, Length=154, Percent_Identity=33.7662337662338, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994943, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787041, Length=183, Percent_Identity=27.3224043715847, Blast_Score=67, Evalue=6e-13,
Organism=Escherichia coli, GI1786253, Length=200, Percent_Identity=29.5, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081834, Length=196, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788761, Length=164, Percent_Identity=30.4878048780488, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787105, Length=205, Percent_Identity=27.8048780487805, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786563, Length=226, Percent_Identity=27.8761061946903, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1786345, Length=157, Percent_Identity=29.9363057324841, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87081782, Length=198, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786703, Length=202, Percent_Identity=30.1980198019802, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789586, Length=197, Percent_Identity=27.9187817258883, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790544, Length=200, Percent_Identity=28.5, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787113, Length=197, Percent_Identity=31.4720812182741, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787164, Length=203, Percent_Identity=32.0197044334975, Blast_Score=60, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=189, Percent_Identity=28.042328042328, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193211017, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193211015, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71996809, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI115533608, Length=176, Percent_Identity=28.9772727272727, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=189, Percent_Identity=26.984126984127, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17533971, Length=192, Percent_Identity=24.4791666666667, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567265, Length=189, Percent_Identity=29.1005291005291, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17511077, Length=191, Percent_Identity=27.2251308900524, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=189, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17541710, Length=194, Percent_Identity=27.319587628866, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193208177, Length=196, Percent_Identity=27.0408163265306, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=192, Percent_Identity=27.6041666666667, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585091, Length=177, Percent_Identity=28.8135593220339, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550390, Length=197, Percent_Identity=26.3959390862944, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574744, Length=187, Percent_Identity=27.807486631016, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574533, Length=186, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24659289, Length=200, Percent_Identity=27, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17136662, Length=189, Percent_Identity=27.5132275132275, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397593, Length=189, Percent_Identity=29.6296296296296, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648314, Length=208, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484234, Length=177, Percent_Identity=25.9887005649718, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- InterPro:   IPR004329
- InterPro:   IPR012340 [H]

Pfam domain/function: PF00005 ABC_tran; PF03100 CcmE [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22336; Mature: 22336

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLEARDLYCERDERTLFRGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYW
CCCCCCCHHCCCHHHHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEE
QGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFED
CCCHHHHHHHHHHHHEEEEECCCCCCEEEEHHCCEEEECCCCCCHHHHHHHHHCCCCCCC
VPVAQLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVIL
CCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCEEEE
TTHQPLPGAADTVRRLALTGGGAGL
EECCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLEARDLYCERDERTLFRGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYW
CCCCCCCHHCCCHHHHHHCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEE
QGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFED
CCCHHHHHHHHHHHHEEEEECCCCCCEEEEHHCCEEEECCCCCCHHHHHHHHHCCCCCCC
VPVAQLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVIL
CCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCEEEE
TTHQPLPGAADTVRRLALTGGGAGL
EECCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA