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The map label for this gene is dnaA [H]

Identifier: 29143975

GI number: 29143975

Start: 3790618

End: 3792018

Strand: Direct

Name: dnaA [H]

Synonym: t3681

Alternate gene names: 29143975

Gene position: 3790618-3792018 (Clockwise)

Preceding gene: 29143966

Following gene: 29143976

Centisome position: 79.1

GC content: 52.96

Gene sequence:

>1401_bases
GTGTCACTTTCGCTTTGGCAGCAGTGTCTTGCCCGATTGCAGGATGAGTTACCAGCCACAGAATTCAGTATGTGGATACG
CCCGTTGCAGGCGGAACTGAGCGATAACACGCTGGCTTTGTATGCGCCAAACCGTTTTGTGCTCGATTGGGTAAGAGATA
AGTACCTCAACAATATCAATGGATTACTCAACACATTCTGCGGCGCGGATGCCCCACAACTGCGTTTTGAAGTGGGAACA
AAGCCCGTTACGCAAACGCTAAAAACGCCTGTGCATAACGTTGTCGCGCCTACGCAGACAACGACGGCGCAACCGCAGCG
CGTAGCGCCCGCGGCCCGTTCGGGCTGGGATAACGTACCAGCGCCGGCGGAGCCGACCTACCGCTCCAACGTCAATGTTA
AGCATACATTTGATAACTTCGTCGAAGGTAAATCCAACCAACTGGCGCGCGCGGCGGCACGTCAGGTGGCGGATAATCCT
GGCGGCGCCTATAACCCGTTATTCCTCTATGGCGGCACCGGTCTGGGTAAAACTCACCTGCTGCACGCGGTGGGTAACGG
CATTATGGCGCGCAAACCCAACGCGAAAGTCGTGTATATGCACTCCGAGCGCTTTGTGCAGGACATGGTAAAAGCCCTGC
AAAATAACGCCATCGAAGAGTTTAAACGCTACTACCGCTCCGTTGACGCATTGCTGATCGACGATATTCAATTCTTCGCC
AATAAAGAACGATCCCAGGAAGAGTTTTTCCACACCTTTAACGCTCTGCTGGAAGGCAATCAGCAGATCATTTTGACGTC
GGATCGCTATCCGAAAGAGATCAACGGCGTTGAGGATCGTCTCAAGTCCCGCTTTGGTTGGGGGCTGACAGTGGCGATCG
AACCACCAGAGCTGGAAACCCGCGTGGCGATCCTGATGAAAAAAGCGGACGAAAATGATATTCGTCTGCCAGGCGAAGTA
GCGTTCTTTATCGCCAAGCGTCTACGCTCTAACGTACGTGAACTGGAAGGCGCGCTGAACCGGGTGATCGCCAATGCCAA
CTTTACCGGCCGGGCGATTACTATCGACTTTGTGCGCGAAGCGCTGCGCGATTTACTGGCGTTGCAGGAAAAACTGGTCA
CCATCGACAATATTCAGAAGACGGTGGCCGAGTATTACAAAATCAAAATTGCGGATCTGCTTTCTAAGCGTCGATCTCGC
TCGGTAGCACGTCCGCGCCAGATGGCTATGGCGCTGGCAAAAGAGCTCACCAACCACAGTCTGCCGGAAATCGGCGATGC
GTTTGGCGGGCGCGACCACACTACCGTACTTCATGCCTGTCGTAAAATTGAGCAACTGCGTGAAGAAAGCCACGATATCA
AAGAAGATTTTTCGAATTTAATCAGAACATTGTCGTCGTGA

Upstream 100 bases:

>100_bases
AGTGCGTCACCCTTCATGCAGGGTCTTATCGACGTGCGCCAACAATCATTAATGTATCAGCCTTTGTCATTTATCGACTT
TTGTTCGAGTGGAGTCCGCC

Downstream 100 bases:

>100_bases
TCCTATGAAATTTACCGTTGAACGTGAACATTTATTAAAACCGCTTCAGCAGGTCAGCGGCCCGCTGGGCGGTCGTCCTA
CGCTGCCGATTCTCGGTAAC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNTFCGADAPQLRFEVGT
KPVTQTLKTPVHNVVAPTQTTTAQPQRVAPAARSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNP
GGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA
NKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEV
AFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSR
SVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS

Sequences:

>Translated_466_residues
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNTFCGADAPQLRFEVGT
KPVTQTLKTPVHNVVAPTQTTTAQPQRVAPAARSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNP
GGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA
NKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEV
AFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSR
SVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
>Mature_465_residues
SLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNTFCGADAPQLRFEVGTK
PVTQTLKTPVHNVVAPTQTTTAQPQRVAPAARSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPG
GAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFAN
KERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVA
FFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSRS
VARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=467, Percent_Identity=96.1456102783726, Blast_Score=930, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=245, Percent_Identity=26.9387755102041, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 52629; Mature: 52497

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNIN
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
GLLNTFCGADAPQLRFEVGTKPVTQTLKTPVHNVVAPTQTTTAQPQRVAPAARSGWDNVP
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHCCCCCCC
APAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHL
CCCCCCCCCCCCEEECHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHH
LHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA
HHHHCCCCEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELET
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCCHHHHHHHHCCCCEEEEECCCCHHH
RVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVRE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHH
ALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSRSVARPRQMAMALAKELTNHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
LPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNIN
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
GLLNTFCGADAPQLRFEVGTKPVTQTLKTPVHNVVAPTQTTTAQPQRVAPAARSGWDNVP
HHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHCCCCCCC
APAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHL
CCCCCCCCCCCCEEECHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHH
LHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA
HHHHCCCCEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELET
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCCHHHHHHHHCCCCEEEEECCCCHHH
RVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVRE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHH
ALRDLLALQEKLVTIDNIQKTVAEYYKIKIADLLSKRRSRSVARPRQMAMALAKELTNHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
LPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA